5-Hydroxymethyluracil

Modify Date: 2024-01-02 16:31:57

5-Hydroxymethyluracil structure	Common Name	5-Hydroxymethyluracil
	CAS Number	4433-40-3	Molecular Weight	142.113
	Density	1.4±0.1 g/cm3	Boiling Point	530.4ºC at 760mmHg
	Molecular Formula	C₅H₆N₂O₃	Melting Point	>300 °C(lit.)
	MSDS	Chinese USA	Flash Point	274.6ºC

Use of 5-Hydroxymethyluracil

5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.

Name	5-hydroxymethyluracil
Synonym	More Synonyms

Description	5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.
Related Catalog	Natural Products >> Others Research Areas >> Others
Target	Human Endogenous Metabolite
References	[1]. Djuric Z, et al. Quantitation of 5-(hydroxymethyl)uracil in DNA by gas chromatography with mass spectral detection. Chem Res Toxicol. 1991 Nov-Dec;4(6):687-91. [2]. Janoušková M, et al. 5-(Hydroxymethyl)uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase. Chem Commun (Camb). 2017 Dec 12;53(99):13253-13255.

Density	1.4±0.1 g/cm3
Boiling Point	530.4ºC at 760mmHg
Melting Point	>300 °C(lit.)
Molecular Formula	C₅H₆N₂O₃
Molecular Weight	142.113
Flash Point	274.6ºC
Exact Mass	142.037842
PSA	86.47000
LogP	-0.50
Index of Refraction	1.528
Storage condition	Refrigerator

5-Hydroxymethyluracil MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YR0513000

CHEMICAL NAME :: Uracil, 5-(hydroxymethyl)-

CAS REGISTRY NUMBER :: 4433-40-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C5-H6-N2-O3

MOLECULAR WEIGHT :: 142.13

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 400 nmol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 48,5466,1988

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	YR0513000
HS Code	2933599090

Precursor 10
CAS#:50-00-0 Formaldehyde CAS#:66-22-8 Uracil CAS#:65-71-4 Thymine CAS#:89179-86-2 2,4(1H,3H)-Pyri...
CAS#:3590-48-5 5-(chloromethyl... CAS#:107-21-1 Ethylene glycol CAS#:825649-02-3 5-(N-methoxymet... CAS#:876495-24-8 5-isocyanatomet...
CAS#:856152-76-6 2-ethylmercapto... CAS#:84345-71-1 5-((benzo[d]oxa...
DownStream 10
CAS#:111878-20-7 [2,4-bis(trimet... CAS#:5116-24-5 5-Hydroxymethyl... CAS#:65-71-4 Thymine CAS#:7627-38-5 2,4-Dichloro-5-...
CAS#:696-04-8 Dihydrothymine CAS#:108141-35-1 2,4-Dichloro-5-... CAS#:3590-48-5 5-(chloromethyl... CAS#:1195-08-0 5-Formyluracil
CAS#:17187-50-7 2,4(1H,3H)-Pyri... CAS#:19396-06-6 POLYOXIN B

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Measurement of urinary excretion of 5-hydroxymethyluracil in human by GC/NICI/MS: correlation with cigarette smoking, urinary TBARS and etheno DNA adduct.

Toxicol. Lett. 155(3) , 403-10, (2005)

5-Hydroxymethyluracil (5-HMU) is derived from radiation in addition to endogenous oxidative DNA damage and it is one of the most abundant DNA adducts. Human 5-HMU-DNA-glycosylase has been shown to rep...

Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase.

Nucleic Acids Res. 32(17) , 5291-302, (2004)

Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1), previously thought to be a backup enzyme for uracil-DNA glycosylase, has recently been shown to excise 5-hydroxyuracil (hoU), 5-h...

Qualitative and quantitative analyses of the decomposition products that arise from the exposure of thymine to monochromatic ultrasoft X rays and 60Co gamma rays in the solid state.

Radiat. Res. 161(4) , 442-50, (2004)

HPLC analyses of condensed thymine irradiated with monochromatic synchrotron ultrasoft X rays in the energy region around nitrogen and oxygen K-shell edges were performed. Cobalt-60 gamma rays were us...

5-(hydroxymethyl)-1H-pyrimidine-2,4-dione

EINECS 224-636-5

2,4-Pyrimidinediol, 5-(hydroxymethyl)-

5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

5-hydroxymethyluracil

MFCD00056024

2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)-

5-(hydroxymethyl)-1,3-dihydropyrimidine-2,4-dione

5-(Hydroxymethyl)uracil

5-(Hydroxymethyl)-2,4(1H,3H)-pyrimidinedione

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 5-Hydroxymethyluracil
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 5-Hydroxymethyluracil
Price: ￥3828.0/100g ￥458.0/5g ￥1538.0/25g ￥768.0/10g
Purity: 98.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-Hydroxymethyluracil
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥550/10 mM * 1 mL in DMSO

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5-Hydroxymethyluracil

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