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4433-40-3

4433-40-3 structure
4433-40-3 structure

Name 5-hydroxymethyluracil
Synonyms 5-(hydroxymethyl)-1H-pyrimidine-2,4-dione
EINECS 224-636-5
2,4-Pyrimidinediol, 5-(hydroxymethyl)-
5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione
5-hydroxymethyluracil
MFCD00056024
2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)-
5-(hydroxymethyl)-1,3-dihydropyrimidine-2,4-dione
5-(Hydroxymethyl)uracil
5-(Hydroxymethyl)-2,4(1H,3H)-pyrimidinedione
Description 5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Djuric Z, et al. Quantitation of 5-(hydroxymethyl)uracil in DNA by gas chromatography with mass spectral detection. Chem Res Toxicol. 1991 Nov-Dec;4(6):687-91.

[2]. Janoušková M, et al. 5-(Hydroxymethyl)uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase. Chem Commun (Camb). 2017 Dec 12;53(99):13253-13255.

Density 1.4±0.1 g/cm3
Boiling Point 530.4ºC at 760mmHg
Melting Point >300 °C(lit.)
Molecular Formula C5H6N2O3
Molecular Weight 142.113
Flash Point 274.6ºC
Exact Mass 142.037842
PSA 86.47000
LogP -0.50
Index of Refraction 1.528
Storage condition Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YR0513000
CHEMICAL NAME :
Uracil, 5-(hydroxymethyl)-
CAS REGISTRY NUMBER :
4433-40-3
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C5-H6-N2-O3
MOLECULAR WEIGHT :
142.13

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
400 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 48,5466,1988
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS YR0513000
HS Code 2933599090
HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%