AZD4877 structure
|
Common Name | AZD4877 | ||
---|---|---|---|---|
CAS Number | 758722-49-5 | Molecular Weight | 503.66 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C28H33N5O2S | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of AZD4877AZD4877 is another isostere to Ispinesib (HY-50759)and also a kinesin spindle protein (Eg5) inhibitor with IC50 of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity[1][2][3][4][5]. |
Name | AZD4877 |
---|
Description | AZD4877 is another isostere to Ispinesib (HY-50759)and also a kinesin spindle protein (Eg5) inhibitor with IC50 of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity[1][2][3][4][5]. |
---|---|
Related Catalog | |
Target |
IC50: 2 nM (Eg5)[5] |
References |
Molecular Formula | C28H33N5O2S |
---|---|
Molecular Weight | 503.66 |