L 888607
Modify Date: 2024-02-27 01:26:53
L 888607 structure
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Common Name | L 888607 | ||
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| CAS Number | 860033-06-3 | Molecular Weight | 375.844 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 583.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C19H15ClFNO2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 306.9±30.1 °C | |
Use of L 888607L 888607 is a potent, and selective CRTH2 (also known as DP2) agonist with a Ki of 0.8±0.4 nM. |
| Name | L-888607 |
|---|---|
| Synonym | More Synonyms |
| Description | L 888607 is a potent, and selective CRTH2 (also known as DP2) agonist with a Ki of 0.8±0.4 nM. |
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| Related Catalog | |
| Target |
CRTH2/DP2 Receptor:0.8 nM (Ki) DP/DP1 Receptor:2331 nM (Ki) TP Receptor:283 nM (Ki) EP2 Receptor:8748 nM (Ki) EP3-III Receptor:1260 nM (Ki) EP4 Receptor:4634 nM (Ki) FP Receptor:10018 nM (Ki) IP Receptor:14434 nM (Ki) |
| In Vivo | L 888607 (L-888,607) is administered to mice either intravenously (i.v.) or orally (p.o.) to determine its pharmacokinetic profile over an 8-h period. After an intravenous administration of 5 mg/kg L 888607, blood analysis reveals a peak level (Cmax) of 36.1 μM, a half-life (t1/2) of 2.9 h, a trough level at 8 h (C8h) of 3.5 μM, and an area under the curve0-8h of 87.1 μM. After oral administration of 20 mg/kg L 888607, blood analysis reveals a Cmax of 31.6 μM, a t1/2 of 4 h, a C8h at 8 h of 15.4 μM, an area under the curve0-8h of 166 μM, and a bioavailability of 48%[1]. |
| Animal Admin | Mice[1] Male (ICR)BR mice with an average weight of 42 g are used. A single dose [5 mg/kg in 60% (v/v) polyethylene glycol 200] of L 888607 is given intravenously via the saphenous vein or a single dose (20 mg/kg in 60% (v/v) polyethylene glycol 400) is given orally by gavage. No obvious side effects are observed. Blood (10 μL) is taken from the jugular vein at each time point indicated and added to 30 μL of 0.1 M aqueous trisodium citrate. The mixture is kept at -20°C until analysis[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 583.8±50.0 °C at 760 mmHg |
| Molecular Formula | C19H15ClFNO2S |
| Molecular Weight | 375.844 |
| Flash Point | 306.9±30.1 °C |
| Exact Mass | 375.049591 |
| LogP | 5.37 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.689 |
| Storage condition | 2-8℃ |
| {(1S)-9-[(4-Chlorophenyl)sulfanyl]-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl}acetic acid |
| L-888607 |
| 1H-Pyrrolo[1,2-a]indole-1-acetic acid, 9-[(4-chlorophenyl)thio]-6-fluoro-2,3-dihydro-, (1S)- |
| LMX71OP17X |