苯肼
苯肼用途
用于制染料、药物、显影剂等
【用途二】
用作分析试剂及色谱分析试剂
【用途三】
苯肼在农药生产上用于合成有机磷杀虫剂三唑磷的中间体1-苯基氨基脲、哒嗪硫磷的中间体1-苯基-3，6-二羟基哒嗪，也是杀菌剂新品种噁唑菌酮(famoxadone)、咪唑菌酮(fenamidone)的中间体，此外，苯肼作为一种有机合成原料，也用作染料、医药等行业的中间体，还用作分析试剂。
【用途四】
该品是染料、医药、农药的中间体，用于生产色酚AS-G、药物安替比林等。将苯肼溶于95%乙醇中，然后加入苯甲醛，回流1h可得苯腙。苯腙也是有机合成中间体。苯肼也用作分析试剂。
【用途五】
作为弱碱用于使铅、铬和其他三价、四价元素以氢氧化物形式沉淀出来。光度测定铝、铬、铜、钼、钛、锆。检定金、铱、钼、钯、铂、银。比色测定磷酸的还原剂。可与醛、酮、糖形成熔点不同的苯腙，据以鉴别这些物质。
苯肼名称
[ CAS 号 ]:
100-63-0
[ 中文名 ]:
苯肼
[ 英文名 ]:
Phenylhydrazine
[中文别名 ]:
[英文别名 ]:
- Fenilidrazina [Italian]
- EINECS 202-873-5
- Hydrazine,phenyl
- Fenylhydrazine [Dutch]
- Hydrazinobenzene
- Hydrazine-benzene
- Phenylhydrazine
- MFCD00007573
- Phenylhydrazin
- N-phenyl hydrazine
苯肼物理化学性质
[ 密度 ]:
1.099 g/mL at 25 °C(lit.)
[ 沸点 ]:
238-241 °C(lit.)
[ 熔点 ]:
19 °C
[ 分子式 ]:
C6H8N2
[ 分子量 ]:
108.14100
[ 闪点 ]:
89 ºC
[ 精确质量 ]:
108.06900
[ PSA ]:
38.05000
[ LogP ]:
1.74550
[ 外观性状 ]:
黄色至淡棕色油性液体
[ 蒸汽密度 ]:
4.3 (vs air)
[ 蒸汽压 ]:
<0.1 mm Hg ( 20 °C)
[ 折射率 ]:
n20/D 1.607(lit.)
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类、食品添加剂分开存放
[ 稳定性 ]:
Stable, but may decompose in sunlight. May be air or light sensitive. Incompatible with strong oxidizing agents, metal oxides.
[ 水溶解性 ]:
145 g/L (20 ºC)
苯肼MSDS
苯肼毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MV8925000
- CHEMICAL NAME :
- Hydrazine, phenyl-
- CAS REGISTRY NUMBER :
- 100-63-0
- BEILSTEIN REFERENCE NO. :
- 0606080
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 48
- MOLECULAR FORMULA :
- C6-H8-N2
- MOLECULAR WEIGHT :
- 108.16
- WISWESSER LINE NOTATION :
- ZMR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 188 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement Behavioral - muscle contraction or spasticity
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2610 mg/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 175 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2120 mg/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 170 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 170 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 120 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement Behavioral - muscle contraction or spasticity
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement Behavioral - muscle contraction or spasticity
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 70 mg/kg/7D-I
- TOXIC EFFECTS :
- Blood - changes in bone marrow (not otherwise specified) Blood - changes in erythrocyte (RBC) count Blood - changes in platelet count
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5200 mg/kg/52W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 30 mg/kg
- SEX/DURATION :
- female 17-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - behavioral
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 41,1469,1981 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.44 mg/m3 (0.1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 ppm (22 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,207,1971 OSHA PEL (Gen Indu):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 5 ppm (20 mg/m3);Skin JAN 1993 OEL-AUSTRALIA:TWA 5 ppm (20 mg/m3);STEL 10 ppm;Skin;Carcinogen JAN 1993 OEL-BELGIUM:TWA 5 ppm (22 mg/m3);STEL 10 ppm (44 mg/m3);Skin;Carcinogen JAN 1993 OEL-DENMARK:TWA 0.1 ppm (0.6 mg/m3);Skin JAN 1993 OEL-FINLAND:STEL 5 ppm (22 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 5 ppm (22 mg/m3);Skin;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 ppm (22 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (22 mg/m3) JAN 1993 OEL-TURKEY:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (20 mg/m3);STEL 10 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO HYDRAZINES-air:CA CL 0.03 ppm/120M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PHENYLHYDRAZINE-air:CA CL 0.14 ppm/120M (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 57300 No. of Facilities: 56 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 1120 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 57300 No. of Facilities: 10 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 212 (estimated) No. of Female Employees: 19 (estimated)
苯肼安全信息
[ 符号 ]:
GHS06, GHS08, GHS09
[ 信号词 ]:
Danger
[ 危害声明 ]:
H301-H311-H315-H317-H319-H331-H341-H350-H372-H400
[ 警示性声明 ]:
P201-P261-P273-P280-P301 + P310-P305 + P351 + P338
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;
[ 风险声明 (欧洲) ]:
R23/24/25;R36/38;R43;R45;R48/23/24/25;R50;R68
[ 安全声明 (欧洲) ]:
S53-S45-S61
[ 危险品运输编码 ]:
UN 2572 6.1/PG 2
[ WGK德国 ]:
3
[ RTECS号 ]:
MV8925000
[ 包装等级 ]:
II
[ 危险类别 ]:
6.1
[ 海关编码 ]:
2928000090
苯肼合成路线
苯肼上下游产品
苯肼上游产品
苯肼下游产品
苯肼制备
1.由氯化重氮苯经还原而制得。
2.将苯胺与30%的盐酸水溶液以1∶2的摩尔比混合，冷至2℃，并控制温度在0～5℃下慢慢加入6mol／l的亚硝酸钠溶液至淀粉碘化钾试纸变蓝，继续搅拌30min，得重氮盐溶液，备用。在10～15℃下，用浓氢氧化钠将40%的亚硫酸氢钠溶液调至ph值6～7，并冷至0～5℃，搅拌下将上述重氮盐快速加入，之后，继续搅拌15min，当ph 值为6～7时，再升温至70～80℃，并慢慢将浓盐酸用导管通到反应液面以下，加完后恒温1～2h，冷至20℃以下，滤出的结晶即为苯肼盐酸盐。将所得苯肼盐酸盐用少量水溶解，加活性炭脱色，过滤后的滤液加入过量氢氧化钠溶液，冷却至15～20℃用苯或乙醚提取数次，合并提取液，并加入无水碳酸钾干燥，再进行苯或乙醚的回收，所得苯肼粗品在2399Pa下蒸馏，收集137～138℃馏分，即为纯品苯肼。过程反应如下：
苯肼海关
[ 海关编码 ]: 2928000090
[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
苯肼文献
Int. J. Cosmet. Sci. 36(5) , 494-504, (2014)
The present investigation is based on the formulation of water-in-oil (w/o) cream preparations of ascorbic acid (AA) at pH 4-6 using different emollients and humectants.The preparations were stored in...
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.J. Med. Chem. 51 , 6740-51, (2008)
The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared ...
3D intra-stacked CoO/carbon nanocomposites welded by Ag nanoparticles for high-capacity, reversible lithium storage.Nanoscale 7 , 10368-76, (2015)
A wet-chemical, facile strategy is proposed for forming three-dimensional intra-structured nanocomposites to facilitate the development of high performance anodes for lithium ion batteries. The nanoco...
相关化工产品/化学物质：
推荐生产厂家/供应商：
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥78.0/100g
￥318.0/500g
联系人：刘佳
产品详情：苯肼
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥232.0/500g
￥需询单/1g
￥73.0/100g
￥需询单/1g
联系人：阿拉丁
产品详情：苯肼
公司名：山东金悦源新材料有限公司
区域：济南市天桥区
价格：
￥10000.0/1ton
联系人：王思兵
产品详情：苯肼
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相关化合物
【苯肼】化源网提供苯肼CAS号100-63-0，苯肼MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询苯肼上化源网，专业又轻松。>>电脑版：苯肼
标题：苯肼_MSDS_用途_密度_苯肼CAS号【100-63-0】_化源网 地址：https://m.chemsrc.com/mip/cas/100-63-0_402577.html