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N-α-CBZ-L-精氨酸-L-精氨酸4-甲氧基-β-萘酰胺,乙酸盐

用途

Z-精氨酸-精氨酸-4Mβ三乙酸钠是组织蛋白酶B特异性底物,可产生荧光终产物4Mβ钠(λex=355nm,λem=430nm)[1][2]。

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名称

[ CAS 号 ]:
100900-19-4

[ 中文名 ]:
N-α-CBZ-L-精氨酸-L-精氨酸4-甲氧基-β-萘酰胺,乙酸盐

[ 英文名 ]:
NA-CBZ-ARG-ARG 4-METHOXY-B-NAPHTHYLAMIDE

[英文别名 ]:

Z-Arg-Arg 4-methoxy-|A-naphthylamide acetate salt

生物活性

[ 描述 ]:

Z-精氨酸-精氨酸-4Mβ三乙酸钠是组织蛋白酶B特异性底物,可产生荧光终产物4Mβ钠(λex=355nm,λem=430nm)[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 代谢酶/蛋白酶 >> 组织蛋白酶

[ 靶点 ]

Cathepsin B

[参考文献]

[1]. Büth H, et al. HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration. Eur J Cell Biol. 2004 Dec;83(11-12):781-95.

[2]. van den Bos T, et al. Differences in matrix composition between calvaria and long bone in mice suggest differences in biomechanical properties and resorption: Special emphasis on collagen. Bone. 2008 Sep;43(3):459-68.

物理化学性质

[ 分子式 ]:
C₃₃H₄₅N₉O₇

[ 分子量 ]:
679.76600

[ 精确质量 ]:
679.34400

[ PSA ]:
277.33000

[ LogP ]:
6.26020

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H351

[ 警示性声明 ]:
P281

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
40

[ 安全声明 (欧洲) ]:
22-36

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

A simple, economical method for staining gels for cathepsin B-like activity.

Anal. Biochem. 119 , 148, (1982)

In vivo and in vitro evidence for the involvement of cysteine proteinases in bone resorption.

Biochem. Biophys. Res. Commun. 125 , 441, (1984)

The excretion of cathepsin B, a lysosomal cysteine proteinase, by parathyroid hormone-stimulated embryonic mouse calvaria in culture, correlates closely with the extent of bone resorption evaluated by...

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