非那卡因

非那卡因用途

菲那卡因(Holocaine)是一种局部麻醉剂。菲那卡因抑制来自大脑和心脏的红细胞Ca2+-ATP酶和环核苷酸磷酸二酯酶的特异性钙调素依赖性刺激[1][2]。

点击显示

非那卡因名称

[ CAS 号 ]:
101-93-9

[ 中文名 ]:
非那卡因

[ 英文名 ]:
holocalin(p)

[中文别名 ]:

哈樂卡因

[英文别名 ]:

Fenacaine
Holocaine
Phenacaine
Tanicaine

非那卡因生物活性

[ 描述 ]:

菲那卡因(Holocaine)是一种局部麻醉剂。菲那卡因抑制来自大脑和心脏的红细胞Ca2+-ATP酶和环核苷酸磷酸二酯酶的特异性钙调素依赖性刺激[1][2]。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)

研究领域 >> 代谢疾病

[体外研究]

菲那卡因抑制脑和心脏组织中红细胞Ca2+-ATP酶(EC 3.6.1.3)和环核苷酸磷酸二酯酶(EC 3.1.4.17)的特异性钙调素依赖性刺激[1]。菲那卡因(1μM-1 mM)可抑制胰腺葡萄糖诱导的胰岛素分泌[2]。

非那卡因物理化学性质

[ 密度 ]:
1.04g/cm3

[ 沸点 ]:
464.5ºC at 760mmHg

[ 熔点 ]:
117°C

[ 分子式 ]:
C₁₈H₂₂N₂O₂

[ 分子量 ]:
298.37900

[ 闪点 ]:
234.7ºC

[ 精确质量 ]:
298.16800

[ PSA ]:
42.85000

[ LogP ]:
4.71900

[ 蒸汽压 ]:
8.29E-09mmHg at 25°C

[ 折射率 ]:
1.534

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

非那卡因毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AD0350000

CHEMICAL NAME :: Acetamidine, N,N'-bis(p-ethoxyphenyl)-

CAS REGISTRY NUMBER :: 101-93-9

BEILSTEIN REFERENCE NO. :: 2702842

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C18-H22-N2-O2

MOLECULAR WEIGHT :: 298.42

WISWESSER LINE NOTATION :: 2OR DNUY1&MR DO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 53 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932

点击显示

非那卡因安全信息

[ 海关编码 ]:
2925290090

非那卡因合成路线

详细合成路线

非那卡因海关

[ 海关编码 ]: 2925290090

[ 中文概述 ]:
2925290090 其他亚胺及其衍生物，以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%