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克拉珠利

克拉珠利用途

Clazuril(R62690)对两种艾美耳球虫的无性和性发育阶段都有杀球虫作用,导致生命周期完全中断[1]。

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克拉珠利名称

[ CAS 号 ]:
101831-36-1

[ 中文名 ]:
克拉珠利

[ 英文名 ]:
Clazuril

[英文别名 ]:

CLAZURIL
Clazurilum [Latin]
Clazurilo [Spanish]
Clazuril (USAN/INN)
Clazurilo
Clazurilum

克拉珠利生物活性

[ 描述 ]:

Clazuril(R62690)对两种艾美耳球虫的无性和性发育阶段都有杀球虫作用,导致生命周期完全中断[1]。

[ 相关类别 ]:

研究领域 >> 感染

[体内研究]

克拉珠利(2.5毫克/鸽)可迅速抑制卵囊排泄,但在治疗20天后,在粪便中再次观察到卵囊。治疗3至5周后,卵囊再次出现在粪便中,这一事实可能只能通过内源性阶段的持续性来解释,内源性阶段在治疗期间不受影响,而不是通过再次感染[2]。

[参考文献]

[1]. W Coussement, et al. Action of the anticoccidial clazuril on the endogenous stages of Eimeria labbeana and E columbarum in experimentally infected pigeons. Res Vet Sci. 1988 Jul;45(1):117-9.

[2]. J Vercruysse, et al. Efficacy of toltrazuril and clazuril against experimental infections with Eimeria labbeana and E. columbarum in racing pigeons. Avian Dis. Jan-Mar 1990;34(1):73-9.

克拉珠利物理化学性质

[ 密度 ]:
1.48g/cm3

[ 熔点 ]:
196.8°

[ 分子式 ]:
C₁₇H₁₀Cl₂N₄O₂

[ 分子量 ]:
373.19300

[ 精确质量 ]:
372.01800

[ PSA ]:
91.54000

[ LogP ]:
2.88308

[ 折射率 ]:
1.692

克拉珠利合成路线

详细合成路线

克拉珠利文献

Efficacy of selected coccidiostats in sandhill cranes (Grus canadensis) following challenge.

J. Zoo Wildl. Med. 36(3) , 391-400, (2005)

The anticoccidial efficacy of amprolium, clazuril, and monensin were studied in sandhill cranes (Grus canadensis) infected with a mixture of Eimeria spp. oocysts. Five groups of four 1-day-old sandhil...

Action of the anticoccidial clazuril on the endogenous stages of Eimeria labbeana and E columbarum in experimentally infected pigeons.

Res. Vet. Sci. 45(1) , 117-9, (1988)

Racing pigeons were artificially infected with a mixed inoculum of Eimeria labbeana (85 per cent) and E columbarum (15 per cent) and treated orally with 2.5 mg clazuril either on day 1, 2, 3, 4, 5, 6 ...

Efficacy of toltrazuril and clazuril against experimental infections with Eimeria labbeana and E. columbarum in racing pigeons.

Avian Dis. 34(1) , 73-9, (1990)

The efficacy of toltrazuril in comparison with clazuril on heavy experimental Eimeria labbeana and E. columbarum infections in pigeons was investigated. The minimum required dose of toltrazuril to com...

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