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5-碘尿苷

5-碘尿苷用途

5-碘尿苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

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5-碘尿苷名称

[ CAS 号 ]:
1024-99-3

[ 中文名 ]:
5-碘尿苷

[ 英文名 ]:
5-Iodouridine

[英文别名 ]:

5-Iodouridine
5-Iod-uridin
5-Iodoruidine
2,4-Dihydroxy-5-iodo-1-β-D-ribofuranosylpyrimidine
Uridine, 5-iodo-
5-iodo-uridine
EINECS 213-833-1
5-Jod-uridin
5-Iodo-D-uridine
MFCD00006532

5-碘尿苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

[参考文献]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

5-碘尿苷物理化学性质

[ 密度 ]:
2.3±0.1 g/cm3

[ 熔点 ]:
205-207ºC (dec.)(lit.)

[ 分子式 ]:
C₉H₁₁IN₂O₆

[ 分子量 ]:
370.10

[ 精确质量 ]:
369.966156

[ PSA ]:
124.78000

[ LogP ]:
-0.43

[ 外观性状 ]:
固体;White to Light yellow powder to crystal

[ 折射率 ]:
1.748

[ 储存条件 ]:
2-8°C

5-碘尿苷MSDS

5-碘尿苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
22-24/25-36/37/39-27-26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2934999090

5-碘尿苷合成路线

5-碘尿苷上下游产品

5-碘尿苷上游产品

5-碘尿苷下游产品

5-碘尿苷海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-碘尿苷文献

Loss of Foxm1 Results in Reduced Somatotrope Cell Number during Mouse Embryogenesis.

PLoS ONE 10 , e0128942, (2015)

FOXM1, a member of the forkhead box transcription factor family, plays a key role in cell cycling progression by regulating the expression of critical G1/S and G2/M phase transition genes. In vivo stu...

Synthesis of uridine phosphoramidite analogs: reagents for site-specific incorporation of photoreactive sites into RNA sequences.

Bioconjug. Chem. 5(6) , 508-12, (1994)

The synthesis of three new photoactive RNA phosphoramidites, 5-bromouridine, 5-iodouridine, and O4-triazolouridine, is reported. The 5' OH of bromouridine and iodouridine were protected as dimethoxytr...

Phosphine containing oligonucleotides for the development of metallodeoxyribozymes.

Chem. Commun. (Camb.) (15) , 1556-8, (2007)

Novel transition metal catalysts based on oligonucleotides can be easily obtained by functionalization of 5-iodouridine with phosphine ligands, resulting in good asymmetric induction in palladium cata...

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