阿糖尿苷

阿糖尿苷用途

1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) 是一种从加勒比海绵 Tectitethya crypta 中分离出的甲氧基腺苷衍生物。已经证明其具有多种生物活性,包括抗炎活性,镇痛和血管舒张特性。1-beta-D-Arabinofuranosyluracil 会抑制小鼠淋巴瘤细胞的增殖。

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阿糖尿苷名称

[ CAS 号 ]:
3083-77-0

[ 中文名 ]:
阿糖尿苷

[ 英文名 ]:
1-β-D-Arabinofuranosyluracil

[中文别名 ]:

[英文别名 ]:

Uracil 1-β-D-Arabinofuranoside
1-Pentofuranosyl-2,4(1H,3H)-pyrimidinedione
4-Hydroxy-1-pentofuranosylpyrimidin-2(1H)-one
1-pentofuranosylpyrimidine-2,4(1H,3H)-dione
Uracil arabinoside
Spongouridine
1-β-D-Arabinofuranosyluracil
1-.β.-D-Arabinofuranosyluracil
2,4(1H,3H)-Pyrimidinedione, 1-pentofuranosyl-
MFCD00065998

阿糖尿苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Bertin MJ, et al. Spongosine production by a Vibrio harveyi strain associated with the sponge Tectitethya crypta. J Nat Prod. 2015 Mar 27;78(3):493-9.

[2]. Müller WE, et al. Metabolism of 1-beta-D-arabinofuranosyluracil in mouse L5178Y cells. Cancer Res. 1979 Mar;39(3):1102-7.

阿糖尿苷物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 熔点 ]:
220-222ºC

[ 分子式 ]:
C₉H₁₂N₂O₆

[ 分子量 ]:
244.201

[ 精确质量 ]:
244.069534

[ PSA ]:
124.78000

[ LogP ]:
-1.61

[ 外观性状 ]:
白色至灰白色固体

[ 折射率 ]:
1.643

[ 储存条件 ]:
2-8°C

阿糖尿苷MSDS

阿糖尿苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YQ8818000

CHEMICAL NAME :: Uracil, 1-beta-D-arabinofuranosyl-

CAS REGISTRY NUMBER :: 3083-77-0

BEILSTEIN REFERENCE NO. :: 0028749

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H12-N2-O6

MOLECULAR WEIGHT :: 244.23

WISWESSER LINE NOTATION :: T6NVMVJ A- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 90 mg/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 2820 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,3957,1982

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阿糖尿苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
22-24/25-36-26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YQ8818000

阿糖尿苷合成路线

阿糖尿苷上下游产品

阿糖尿苷上游产品

阿糖尿苷下游产品

阿糖尿苷文献

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Bioorg. Med. Chem. 19(11) , 3520-6, (2011)

New cytostatic antimetabolite-bisphosphonates.

Bioactive compounds from the fern Lepisorus contortus.

J. Nat. Prod. 74 , 129-36, (2011)

Phytochemical investigation of the whole plant of Lepisorus contortus (Christ) Ching led to the isolation of five new phenylethanoid glycosides (1-5), each containing a caffeoyl group, a new flavonoid...

Imaging of a localized bacterial infection with endogenous thymidine kinase using radioisotope-labeled nucleosides.

Int. J. Med. Microbiol. 302(2) , 101-7, (2012)

The importance of noninvasive imaging methods to bacterial infections is widely recognized. To obtain bacterial infection imaging with radioisotope-labeled nucleosides, bacterial thymidine kinase (tk)...

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