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N-苯基硫脲

N-苯基硫脲用途

Phenylthiourea (Phenylthiocarbamide) 是酚氧化酶的抑制剂。Phenylthiourea 抑制酚氧化酶对 DOPA 的酶促氧化 (Ki: 0.21?μM)。
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N-苯基硫脲名称

[ CAS 号 ]:
103-85-5

[ 中文名 ]:
苯基硫脲

[ 英文名 ]:
Phenylthiocarbamide

[中文别名 ]:

[英文别名 ]:

N-苯基硫脲生物活性

[ 描述 ]:

Phenylthiourea (Phenylthiocarbamide) 是酚氧化酶的抑制剂。Phenylthiourea 抑制酚氧化酶对 DOPA 的酶促氧化 (Ki: 0.21?μM)。

[ 相关类别 ]:

研究领域 >> 其他
信号通路 >> 其他 >> 其他

[ 靶点 ]

phenoloxidase[1]


[参考文献]

[1]. Ryazanova AD, et al. The phenylthiourea is a competitive inhibitor of the enzymatic oxidation of DOPA by phenoloxidase. J Enzyme Inhib Med Chem. 2012 Feb;27(1):78-83.  

N-苯基硫脲物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
266.7±23.0 °C at 760 mmHg

[ 熔点 ]:
145-150 °C(lit.)

[ 分子式 ]:
C7H8N2S

[ 分子量 ]:
152.217

[ 闪点 ]:
115.1±22.6 °C

[ 精确质量 ]:
152.040817

[ PSA ]:
70.14000

[ LogP ]:
0.73

[ 外观性状 ]:
略黄色粉末

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.725

[ 储存条件 ]:
Poison room

[ 稳定性 ]:
Stable. Incompatible with strong acids, strong oxidizing agents, strong bases.

[ 水溶解性 ]:
水溶性：实际上不溶；水溶解度：2.47 g/l   25 °C；可溶于：醇

N-苯基硫脲MSDS

详细MSDS(安全技术说明书)

N-苯基硫脲毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YU1400000
CHEMICAL NAME :
Urea, 1-phenyl-2-thio-
CAS REGISTRY NUMBER :
103-85-5
LAST UPDATED :
199710
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C7-H8-N2-S
MOLECULAR WEIGHT :
152.23
WISWESSER LINE NOTATION :
SUYZMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 mg/kg
TOXIC EFFECTS :
Endocrine - hyperglycemia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
168 mg/kg
SEX/DURATION :
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Effects on Embryo or Fetus - other effects to embryo

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Rodent - rat Liver
DOSE/DURATION :
8 mmol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 24,181,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0839 No. of Facilities: 54 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 2415 (estimated) No. of Female Employees: 483 (estimated)
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N-苯基硫脲安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H317

[ 警示性声明 ]:
P264-P280-P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+

[ 风险声明 (欧洲) ]:
R28

[ 安全声明 (欧洲) ]:
S28-S36/37-S45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
YU1400000

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2930909090

N-苯基硫脲合成路线

详细合成路线

N-苯基硫脲上下游产品

N-苯基硫脲上游产品

N-苯基硫脲下游产品

N-苯基硫脲制备

由苯胺先与硫酸成盐，再与硫氰化钠进行加成反应而得。

１．硫氰化钠法　由苯胺先与硫酸成盐，再与硫氰化钠进行加成反应，反应式如下：


２．二苯基硫脲法　由苯胺与二硫化碳作用制二苯基硫脲，再经酸化、氨化而得，反应式如下：
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N-苯基硫脲海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N-苯基硫脲文献

Tweedle cuticular protein BmCPT1 is involved in innate immunity by participating in recognition of Escherichia coli.

Insect Biochem. Mol. Biol. 58 , 76-88, (2015)

Bombyx mori, a lepidopteran insect, is one of the earliest models for pattern recognition of Gram-negative bacteria, which may induce the IMD pathway for production of antibacterial peptides. So far, ...

Cellular Anti-Melanogenic Effects of a Euryale ferox Seed Extract Ethyl Acetate Fraction via the Lysosomal Degradation Machinery.

Int. J. Mol. Sci. 16 , 9217-35, (2015)

The aim of this study was to investigate the effect of ethyl acetate fraction of Euryale ferox seed extracts (Efse-EA) on melanogenesis in immortalized mouse melanocyte cell line, melan-a. Efse-EA sho...

Dietary cholesterol directly induces acute inflammasome-dependent intestinal inflammation.

Nat. Commun. 5 , 5864, (2014)

Prolonged ingestion of a cholesterol- or saturated fatty acid-enriched diet induces chronic, often systemic, auto-inflammatory responses resulting in significant health problems worldwide. In vivo inf...


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相关化合物

【N-苯基硫脲】化源网提供N-苯基硫脲CAS号103-85-5，N-苯基硫脲MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询N-苯基硫脲上化源网，专业又轻松。>>电脑版：N-苯基硫脲

标题：N-苯基硫脲_MSDS_用途_密度_N-苯基硫脲CAS号【103-85-5】_化源网 地址：https://m.chemsrc.com/mip/cas/103-85-5_402717.html