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4-氯苯基异氰酸酯

4-氯苯基异氰酸酯用途

【用途一】
用于有机合成，主要用作医药、农药等中间体
【用途二】
对氯苯异氰酸酯是灭幼脲、除虫脲的中间体。
【用途三】
用作有机合体的中间体。

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4-氯苯基异氰酸酯名称

[ CAS 号 ]:
104-12-1

[ 中文名 ]:
对氯苯异氰酸酯

[ 英文名 ]:
p-Chlorophenyl isocyanate

[中文别名 ]:

对氯苯基异氰酸酯

[英文别名 ]:

4-Chlorophenyl isocyanate
Isocyanic Acid 4-Chlorophenyl Ester
Benzene, 1-chloro-4-isocyanato-
p-Chlorophenyl isocyanate
1-Chloro-4-isocyanatobenzene
EINECS 203-176-9
MFCD00002024

4-氯苯基异氰酸酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
204.2±13.0 °C at 760 mmHg

[ 熔点 ]:
26-29 °C(lit.)

[ 分子式 ]:
C₇H₄ClNO

[ 分子量 ]:
153.566

[ 闪点 ]:
76.0±9.1 °C

[ 精确质量 ]:
152.998138

[ PSA ]:
29.43000

[ LogP ]:
3.42

[ 外观性状 ]:
无色至淡黄色液体

[ 蒸汽压 ]:
0.3±0.4 mmHg at 25°C

[ 折射率 ]:
1.551

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
DECOMPOSES

4-氯苯基异氰酸酯MSDS

详细MSDS(安全技术说明书)

4-氯苯基异氰酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NQ8575000

CHEMICAL NAME :: Isocyanic acid, p-chlorophenyl ester

CAS REGISTRY NUMBER :: 104-12-1

LAST UPDATED :: 199807

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C7-H4-Cl-N-O

MOLECULAR WEIGHT :: 153.57

WISWESSER LINE NOTATION :: OCNR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,931,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0528437 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 800 ug/m3/1M

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes

REFERENCE :: HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 31(7-9),481,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 138 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - gastritis

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0528437

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 113 mg/m3/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555462

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538092

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 62500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538092

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,38,1982

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 53 mg/m3

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 31(9),108,1966

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0528442

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 53 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 11(4),23,1967 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 9500 mg/kg/2W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes primarily in glomeruli Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0528442

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 ug/m3/24H/80D-C

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - other changes in urine composition Endocrine - other changes

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 32(10),103,1967

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 ug/m3/24H/11W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - other proteins

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 32(7),3,1967

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 ug/m3/4H/17W-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Endocrine - changes in thyroid weight

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 31(9),108,1966 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993

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4-氯苯基异氰酸酯安全信息

[ 符号 ]:

GHS05, GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H315-H318-H330-H334-H335-H410

[ 警示性声明 ]:
P260-P273-P280-P284-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+:Verytoxic;

[ 风险声明 (欧洲) ]:
R25;R26;R37/38;R41;R42;R52/53

[ 安全声明 (欧洲) ]:
S23-S26-S28-S36/37/39-S45-S61-S38-S37/39-S28A-S22

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
NQ8575000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2929109000

4-氯苯基异氰酸酯合成路线

详细合成路线

4-氯苯基异氰酸酯上下游产品

4-氯苯基异氰酸酯上游产品

4-氯苯基异氰酸酯下游产品

4-氯苯基异氰酸酯制备

其制备方法是在反应釜中加入对氯苯胺和甲苯，搅拌，使对氯苯胺溶解，然后在低温通光气，通入一定量光气后转入热反应器，升温到 105℃左右，物料变透明，再回流一定时间，通入氮气赶光气，冷却得到产品。

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4-氯苯基异氰酸酯海关

[ 海关编码 ]: 2929109000

[ 中文概述 ]:
2929109000. 其他异氰酸酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2929109000. other isocyanates. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

4-氯苯基异氰酸酯文献

A Convenient synthesis of isothiocyanates from primary nitroalkanes.

Synth. Commun. 24(8) , 1101-1105, (1994)

更多文献

4-氯苯基异氰酸酯

4-氯苯基异氰酸酯用途

4-氯苯基异氰酸酯名称

4-氯苯基异氰酸酯物理化学性质

4-氯苯基异氰酸酯MSDS

详细MSDS(安全技术说明书)

4-氯苯基异氰酸酯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

4-氯苯基异氰酸酯安全信息

4-氯苯基异氰酸酯合成路线

详细合成路线

4-氯苯基异氰酸酯上下游产品

4-氯苯基异氰酸酯上游产品

4-氯苯基异氰酸酯下游产品

4-氯苯基异氰酸酯制备

4-氯苯基异氰酸酯海关

4-氯苯基异氰酸酯文献

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