4-氯苯基异氰酸酯
4-氯苯基异氰酸酯用途
用于有机合成，主要用作医药、农药等中间体
【用途二】
对氯苯异氰酸酯是灭幼脲、除虫脲的中间体。
【用途三】
用作有机合体的中间体。
4-氯苯基异氰酸酯名称
[ CAS 号 ]:
104-12-1
[ 中文名 ]:
对氯苯异氰酸酯
[ 英文名 ]:
p-Chlorophenyl isocyanate
[中文别名 ]:
[英文别名 ]:
- 4-Chlorophenyl isocyanate
- Isocyanic Acid 4-Chlorophenyl Ester
- Benzene, 1-chloro-4-isocyanato-
- p-Chlorophenyl isocyanate
- 1-Chloro-4-isocyanatobenzene
- EINECS 203-176-9
- MFCD00002024
4-氯苯基异氰酸酯物理化学性质
[ 密度 ]:
1.2±0.1 g/cm3
[ 沸点 ]:
204.2±13.0 °C at 760 mmHg
[ 熔点 ]:
26-29 °C(lit.)
[ 分子式 ]:
C7H4ClNO
[ 分子量 ]:
153.566
[ 闪点 ]:
76.0±9.1 °C
[ 精确质量 ]:
152.998138
[ PSA ]:
29.43000
[ LogP ]:
3.42
[ 外观性状 ]:
无色至淡黄色液体
[ 蒸汽压 ]:
0.3±0.4 mmHg at 25°C
[ 折射率 ]:
1.551
[ 储存条件 ]:
2-8°C
[ 水溶解性 ]:
DECOMPOSES
4-氯苯基异氰酸酯MSDS
4-氯苯基异氰酸酯毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NQ8575000
- CHEMICAL NAME :
- Isocyanic acid, p-chlorophenyl ester
- CAS REGISTRY NUMBER :
- 104-12-1
- LAST UPDATED :
- 199807
- DATA ITEMS CITED :
- 19
- MOLECULAR FORMULA :
- C7-H4-Cl-N-O
- MOLECULAR WEIGHT :
- 153.57
- WISWESSER LINE NOTATION :
- OCNR DG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,931,1986
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0528437 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 800 ug/m3/1M
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 31(7-9),481,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 138 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - gastritis
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0528437
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 113 mg/m3/4H
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - other changes
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555462
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538092
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 62500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538092
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 450 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,38,1982
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 53 mg/m3
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 31(9),108,1966
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 6 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0528442
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 53 mg/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 11(4),23,1967 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 9500 mg/kg/2W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes primarily in glomeruli Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0528442
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 ug/m3/24H/80D-C
- TOXIC EFFECTS :
- Liver - other changes Kidney, Ureter, Bladder - other changes in urine composition Endocrine - other changes
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 32(10),103,1967
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5 ug/m3/24H/11W-C
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - other proteins
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 32(7),3,1967
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1400 ug/m3/4H/17W-I
- TOXIC EFFECTS :
- Endocrine - changes in spleen weight Endocrine - changes in thyroid weight
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 31(9),108,1966 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993
4-氯苯基异氰酸酯安全信息
[ 符号 ]:
GHS05, GHS06, GHS08, GHS09
[ 信号词 ]:
Danger
[ 危害声明 ]:
H302-H315-H318-H330-H334-H335-H410
[ 警示性声明 ]:
P260-P273-P280-P284-P305 + P351 + P338-P310
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
T+:Verytoxic;
[ 风险声明 (欧洲) ]:
R25;R26;R37/38;R41;R42;R52/53
[ 安全声明 (欧洲) ]:
S23-S26-S28-S36/37/39-S45-S61-S38-S37/39-S28A-S22
[ 危险品运输编码 ]:
UN 2811 6.1/PG 2
[ WGK德国 ]:
3
[ RTECS号 ]:
NQ8575000
[ 包装等级 ]:
II
[ 危险类别 ]:
6.1
[ 海关编码 ]:
2929109000
4-氯苯基异氰酸酯合成路线
4-氯苯基异氰酸酯上下游产品
4-氯苯基异氰酸酯上游产品
4-氯苯基异氰酸酯下游产品
4-氯苯基异氰酸酯制备
其制备方法是在反应釜中加入对氯苯胺和甲苯，搅拌，使对氯苯胺溶解，然后在低温通光气，通入一定量光气后转入热反应器，升温到 105℃左右，物料变透明，再回流一定时间，通入氮气赶光气，冷却得到产品。
4-氯苯基异氰酸酯海关
[ 海关编码 ]: 2929109000
[ 中文概述 ]:
2929109000. 其他异氰酸酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2929109000. other isocyanates. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
4-氯苯基异氰酸酯文献
Synth. Commun. 24(8) , 1101-1105, (1994)
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￥需询单/1kg
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产品详情：对氯苯基异氰酸酯
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￥188.0/100g
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￥需询单/1kg
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产品详情：对氯苯异氰酸酯
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