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α,β-亚甲基腺苷5'-三磷酸锂盐

用途

α、 β-亚甲基ATP二锂是ATP的膦酸类似物,是P2X3和P2X7受体配体[1]。α、 β-亚甲基ATP二锂是P2X1和P2X3的高选择性激动剂,在P2X2,4-7处几乎没有活性[2]。

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名称

[ CAS 号 ]:
104809-20-3

[ 中文名 ]:
Alpha,β-亚甲基腺苷 5’-三磷酸锂盐

[ 英文名 ]:
α,β-Methylene-ATP dilithium

[英文别名 ]:

生物活性

[ 描述 ]:

α、 β-亚甲基ATP二锂是ATP的膦酸类似物,是P2X3和P2X7受体配体[1]。α、 β-亚甲基ATP二锂是P2X1和P2X3的高选择性激动剂,在P2X2,4-7处几乎没有活性[2]。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> 跨膜转运 >> P2X受体

[参考文献]

[1]. Arribas-Blázquez M, et al. Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain. Int J Mol Sci. 2019 Jan 3;20(1).

[2]. Claudio Coddou, et al. Activation and regulation of purinergic P2X receptor channels. Pharmacol Rev. 2011 Sep;63(3):641-83

物理化学性质

[ 分子式 ]:
C₁₁H₁₈Li₂N₅O₁₂P₃

[ 分子量 ]:
519.09

[ 精确质量 ]:
511.02500

[ PSA ]:
302.16000

[ 外观性状 ]:
固体

[ 储存条件 ]:
20°C

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
22-26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

Plasticity of calcium signaling cascades in human embryonic stem cell-derived neural precursors.

Stem Cells Dev. 22(10) , 1506-21, (2013)

Human embryonic stem cell-derived neural precursors (hESC NPs) are considered to be a promising tool for cell-based therapy in central nervous system injuries and neurodegenerative diseases. The Ca(2+...

Is there a basis for distinguishing two types of P2-purinoceptor?

Gen. Pharmacol. 16 , 433, (1985)

It is suggested that the P2-purinoceptor may be separated into two subtypes largely on the basis of the rank order of agonist potency of structural analogues of ATP and also on the activity of antagon...

The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by alpha, beta-methylene adenosine 5'-triphosphate.

Br. J. Pharmacol. 112 , 282, (1994)

1. We have previously found that the P2x-purinoceptor agonist, alpha, beta-methylene adenosine 5'-triphosphate (alpha, beta-methylene ATP), depolarizes the rat cervical vagus nerve, measured with a 'g...

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