N-甲基二乙醇胺

【用途一】
主要用作乳化剂和酸性气体吸收剂、酸碱控制剂、聚氨酯泡沫催化剂。也用作抗肿瘤药物盐酸氮芥等的中间体。

[ 密度 ]:
1.038

[ 沸点 ]:
243 ºC

[ 熔点 ]:
-21 °C

[ 分子式 ]:
C₅H₁₃NO₂

[ 分子量 ]:
119.162

[ 闪点 ]:
137 ºC

[ 精确质量 ]:
119.094627

[ PSA ]:
43.70000

[ LogP ]:
-0.72

[ 外观性状 ]:
水白色,吸湿的液体，带有一种氨气味

[ 蒸汽密度 ]:
4 (vs air)

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.4675-1.4695

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
MISCIBLE

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

KL7525000

CHEMICAL NAME :

Ethanol, 2,2'-(methylimino)di-

CAS REGISTRY NUMBER :

105-59-9

BEILSTEIN REFERENCE NO. :

1734441

LAST UPDATED :

199806

DATA ITEMS CITED :

9

MOLECULAR FORMULA :

C5-H13-N-O2

MOLECULAR WEIGHT :

119.19

WISWESSER LINE NOTATION :

Q2N1&2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Open irritation test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/13/1971 ** ACUTE TOXICITY DATA **

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

4780 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 10,61,1954

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

500 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

5990 uL/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 10,61,1954 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82845 No. of Facilities: 59 (estimated) No. of Industries: 5 No. of Occupations: 15 No. of Employees: 1677 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82845 No. of Facilities: 203 (estimated) No. of Industries: 5 No. of Occupations: 6 No. of Employees: 6811 (estimated) No. of Female Employees: 1031 (estimated)

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36

[ 安全声明 (欧洲) ]:
S24

[ 危险品运输编码 ]:
2735

[ WGK德国 ]:
1

[ RTECS号 ]:
KL7525000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2922194000

详细合成路线

N-甲基二乙醇胺上游产品

N-甲基二乙醇胺下游产品

1.由甲醛与二乙醇胺反应而得。将甲酸加入反应锅内加热至沸，在搅拌下滴加甲醛和二乙醇胺的混合液，约1h滴完，温度维持在90-98℃，继续回流4h。然后进行减压蒸馏，收集120-130℃（0.53kPa）馏分，即得N-甲基二乙醇胺，收率为85%。

2.由甲胺与环氧乙烷反应而得。温度保持在30℃以下，将环氧乙烷气体通入20%的甲胺溶液中进行加成反应，通至反应液的相对密度达到1.025为止。搅拌15min，相对密度不变即为终点。常压回收甲胺至103℃，减压蒸水后，收集119-170℃（4.67kPa）馏分。即为成品。收率72%。原料消耗定额：环氧乙烷950kg/t、甲胺（40%）870kg/t。此外，以甲醛与氰乙醇为原料，经催化加氢也可制得N-甲基二乙醇胺。

[ 海关编码 ]: 2922194000

[ 中文概述 ]:
2922194000 甲基二乙醇胺。监管条件:23(两用物项和技术进口许可证,两用物项和技术出口许可证)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: 2.两用物项和技术进口许可证 3.两用物项和技术出口许可证

[ Summary ]:
2922194000 2,2'-(methylazanediyl)diethanol。supervision conditions:23(import license for dual-use item and technologies,export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

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联系人：王思兵

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