丁酸酐
丁酸酐用途
用于制备丁酸酯、香料和丁酸纤维素等,医药工业上用作制备胆囊造影剂的原料
【用途二】
制备丁乙酸纤维素、丁酸酯类和香料的原料。在医药上作胆囊造影剂碘泛酸的原料。
【用途三】
制备丁乙酸纤维素;丁酸酯类和香料的原料。在医药上作胆囊造影剂碘泛酸的原料。
丁酸酐名称
[ CAS 号 ]:
106-31-0
[ 中文名 ]:
丁酸酐
[ 英文名 ]:
Butanoic anhydride
[中文别名 ]:
[英文别名 ]:
- Butanoic anhydride
- Butyric Anhydride
- N-Butyric Anhydride
- EINECS 203-383-4
- MFCD00009389
- butanoyl butanoate
丁酸酐物理化学性质
[ 密度 ]:
1.0±0.1 g/cm3
[ 沸点 ]:
198.3±8.0 °C at 760 mmHg
[ 熔点 ]:
−75-−66 °C(lit.)
[ 分子式 ]:
C8H14O3
[ 分子量 ]:
158.195
[ 闪点 ]:
87.8±0.0 °C
[ 精确质量 ]:
158.094299
[ PSA ]:
43.37000
[ LogP ]:
1.64
[ 外观性状 ]:
透明液体
[ 蒸汽密度 ]:
5.45 (vs air)
[ 蒸汽压 ]:
0.4±0.4 mmHg at 25°C
[ 折射率 ]:
1.421
[ 储存条件 ]:
包装完整、轻装轻卸,库房通风、远离明火、高温、与氧化剂分开存放
[ 水溶解性 ]:
Decomposes
丁酸酐MSDS
丁酸酐毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- ET7090000
- CHEMICAL NAME :
- Butyric anhydride
- CAS REGISTRY NUMBER :
- 106-31-0
- BEILSTEIN REFERENCE NO. :
- 1099474
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C8-H14-O3
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8790 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,321,1986
- TYPE OF TEST :
- LC - Lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >50 mg/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 4,29,1962
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Liver - other changes Kidney, Ureter, Bladder - other changes
- REFERENCE :
- TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 4,29,1962
- TYPE OF TEST :
- LC - Lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >50 mg/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 4,29,1962 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 30 mg/m3/2H/30D-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi
- REFERENCE :
- TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 3,48,1961 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5716 No. of Facilities: 25 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 4817 (estimated) No. of Female Employees: 755 (estimated)
丁酸酐安全信息
[ 符号 ]:
GHS05
[ 信号词 ]:
Danger
[ 危害声明 ]:
H314
[ 补充危害声明 ]:
Reacts violently with water.
[ 警示性声明 ]:
P280-P305 + P351 + P338-P310
[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
C:Corrosive;
[ 风险声明 (欧洲) ]:
R34
[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45
[ 危险品运输编码 ]:
UN 2739 8/PG 3
[ WGK德国 ]:
1
[ RTECS号 ]:
ET7090000
[ 包装等级 ]:
III
[ 危险类别 ]:
8
[ 海关编码 ]:
2915900090
丁酸酐合成路线
丁酸酐上下游产品
丁酸酐上游产品
丁酸酐下游产品
丁酸酐制备
丁酐可由丁酰氯与丁酸钠共热而得,或由丁酸与乙酐交换法制备。丁酸和乙酐在触媒存在下加热进行反应得丁肝,副产醋酸,然后经分离、精制即得成品。其他的制法有丁酸用一氯化硫处理,或丁酸与乙烯酮(或二乙烯酮)反应,或丁酸与甲基乙炔反应,都可得到丁酐。
精制方法:用五氧化二磷干燥后蒸馏。
丁酸酐海关
[ 海关编码 ]: 2915900090
[ 中文概述 ]:
2915900090. 其他饱和无环一元羧酸及其酸酐(酰卤、过氧)化物、过氧酸及其卤化、硝化、磺化、亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单
[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%
丁酸酐文献
J. Oleo Sci. 64 , 845-52, (2015)
Ferulic acid was modified to produce a novel phenolipid containing butyl chains. Ferulic acid was esterified with butanol to produce butyl ferulate which was further dihydroxylated followed by esterif...
Evaluation of dibutyrylchitin as new excipient for sustained drug release.Drug Dev. Ind. Pharm. 38(8) , 979-84, (2012)
Dibutyrylchitin (DBC), a lipophilic chitin diester, has been synthesized from chitin and butyric anhydride with methanesulfonic acid as catalyst. Exhaustive esterification of free alcoholic groups of ...
Hyaluronic acid as drug delivery for sodium butyrate: improvement of the anti-proliferative activity on a breast-cancer cell line.Int. J. Cancer 81(3) , 411-6, (1999)
The potential clinical utility of sodium butyrate, a natural compound known to inhibit tumor-cell growth, is hampered by the difficulty of achieving effective in-vivo concentrations. The short half-li...
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联系人:徐经理
产品详情:丁酸酐
公司名:上海吉至生化科技有限公司
区域:上海市奉贤区
价格:
¥308.0/500ml
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产品详情:丁酸酐
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥需询单/1mg
¥需询单/1mg
¥需询单/1mg
¥需询单/1mg
联系人:阿拉丁
产品详情:丁酸酐
公司名:中山市迪欣化工有限公司
区域:中山市三角镇
价格:
¥30.0/1000kg
联系人:王洁
产品详情:正丁酸酐
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相关化合物
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