丁酸酐

【用途一】
用于制备丁酸酯、香料和丁酸纤维素等，医药工业上用作制备胆囊造影剂的原料
【用途二】
制备丁乙酸纤维素、丁酸酯类和香料的原料。在医药上作胆囊造影剂碘泛酸的原料。
【用途三】
制备丁乙酸纤维素；丁酸酯类和香料的原料。在医药上作胆囊造影剂碘泛酸的原料。

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
198.3±8.0 °C at 760 mmHg

[ 熔点 ]:
−75-−66 °C(lit.)

[ 分子式 ]:
C₈H₁₄O₃

[ 分子量 ]:
158.195

[ 闪点 ]:
87.8±0.0 °C

[ 精确质量 ]:
158.094299

[ PSA ]:
43.37000

[ LogP ]:
1.64

[ 外观性状 ]:
透明液体

[ 蒸汽密度 ]:
5.45 (vs air)

[ 蒸汽压 ]:
0.4±0.4 mmHg at 25°C

[ 折射率 ]:
1.421

[ 储存条件 ]:
包装完整、轻装轻卸,库房通风、远离明火、高温、与氧化剂分开存放

[ 水溶解性 ]:
Decomposes

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

ET7090000

CHEMICAL NAME :

Butyric anhydride

CAS REGISTRY NUMBER :

106-31-0

BEILSTEIN REFERENCE NO. :

1099474

LAST UPDATED :

199710

DATA ITEMS CITED :

9

MOLECULAR FORMULA :

C8-H14-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

8790 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,321,1986

TYPE OF TEST :

LC - Lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>50 mg/m3

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 4,29,1962

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1 gm/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Liver - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :

TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 4,29,1962

TYPE OF TEST :

LC - Lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>50 mg/m3

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 4,29,1962 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

30 mg/m3/2H/30D-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi

REFERENCE :

TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 3,48,1961 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5716 No. of Facilities: 25 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 4817 (estimated) No. of Female Employees: 755 (estimated)

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 补充危害声明 ]:
Reacts violently with water.

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2739 8/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
ET7090000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2915900090

详细合成路线

丁酸酐上游产品

丁酸酐下游产品

丁酐可由丁酰氯与丁酸钠共热而得，或由丁酸与乙酐交换法制备。丁酸和乙酐在触媒存在下加热进行反应得丁肝，副产醋酸，然后经分离、精制即得成品。其他的制法有丁酸用一氯化硫处理，或丁酸与乙烯酮（或二乙烯酮）反应，或丁酸与甲基乙炔反应，都可得到丁酐。

精制方法：用五氧化二磷干燥后蒸馏。

[ 海关编码 ]: 2915900090

[ 中文概述 ]:
2915900090. 其他饱和无环一元羧酸及其酸酐（酰卤、过氧）化物、过氧酸及其卤化、硝化、磺化、亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Synthesis and Characterization of a Novel Phenolic Lipid for Use as Potential Lipophilic Antioxidant and as a Prodrug of Butyric Acid.

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Drug Dev. Ind. Pharm. 38(8) , 979-84, (2012)

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Hyaluronic acid as drug delivery for sodium butyrate: improvement of the anti-proliferative activity on a breast-cancer cell line.

Int. J. Cancer 81(3) , 411-6, (1999)

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：丁酸酐

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥308.0/500ml

联系人：刘佳

产品详情：丁酸酐

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥需询单/1mg ￥需询单/1mg ￥需询单/1mg ￥需询单/1mg

联系人：阿拉丁

产品详情：丁酸酐

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公司名：中山市迪欣化工有限公司

区域：中山市三角镇

价格：
￥30.0/1000kg

联系人：陈雪萍

产品详情：正丁酸酐

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