1,2-环氧丁烷
1,2-环氧丁烷用途
用于制造中间体和聚合物，例如用来生产1,2-丁二醇。还用来代替丙酮作为硝基漆的稀释剂，1,2-环氧丁烷也可作为色谱分析的标准物质。
1,2-环氧丁烷名称
[ CAS 号 ]:
106-88-7
[ 中文名 ]:
1,2-环氧丁烷
[ 英文名 ]:
1,2-EPOXYBUTANE
[中文别名 ]:
[英文别名 ]:
- Ethylethylene Oxide
- MFCD00005153
- EINECS 203-438-2
- 1,2-Butylene Oxide
- Ethyloxirane
- 1,2-EPOXYBUTANE
1,2-环氧丁烷物理化学性质
[ 密度 ]:
0.837 g/mL at 25 °C(lit.)
[ 沸点 ]:
63 °C(lit.)
[ 熔点 ]:
-130ºC
[ 分子式 ]:
C4H8O
[ 分子量 ]:
72.10570
[ 闪点 ]:
10 °F
[ 精确质量 ]:
72.05750
[ PSA ]:
12.53000
[ LogP ]:
0.79520
[ 外观性状 ]:
无色液体
[ 蒸汽密度 ]:
2.2 (vs air)
[ 蒸汽压 ]:
184mmHg at 25°C
[ 折射率 ]:
n20/D 1.384
[ 储存条件 ]:
库房通风低温干燥,与氧化剂,食品原料分开存放,不宜久储,以防爆炸
[ 水溶解性 ]:
水溶性：可溶；水溶解度：95 g/l 25 °C
1,2-环氧丁烷MSDS
1,2-环氧丁烷毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EK3675000
- CHEMICAL NAME :
- Butane, 1,2-epoxy-
- CAS REGISTRY NUMBER :
- 106-88-7
- BEILSTEIN REFERENCE NO. :
- 0102411
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 48
- MOLECULAR FORMULA :
- C4-H8-O
- MOLECULAR WEIGHT :
- 72.12
- WISWESSER LINE NOTATION :
- T3OTJ B2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4000 ppm/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 398 ppm/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2100 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 800 ppm/6H/13W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1600 ppm/6H/14D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 600 ppm/6H/13W-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 800 ppm/6H/14D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 400 ppm/6H/13W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1600 ppm/6H/2W-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 600 ppm/6H/13W-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 ppm/6H/5D/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 1000 ppm/7H
- SEX/DURATION :
- female 1-24 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- Specific locus test
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Heritable translocation test
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 100 mmol/L
- REFERENCE :
- CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 9,97,1974 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 47,217,1989 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 47,217,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9126 No. of Facilities: 14049 (estimated) No. of Industries: 166 No. of Occupations: 104 No. of Employees: 261650 (estimated) No. of Female Employees: 42961 (estimated)
1,2-环氧丁烷安全信息
[ 符号 ]:
GHS02, GHS07, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H225-H302 + H312 + H332-H315-H319-H335-H351-H412
[ 警示性声明 ]:
P210-P261-P273-P280-P305 + P351 + P338
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)
[ 危害码 (欧洲) ]:
F;Xn
[ 风险声明 (欧洲) ]:
R11;R20/21/22;R36/37/38;R40;R52/53
[ 安全声明 (欧洲) ]:
S9-S16-S29-S36/37-S61
[ 危险品运输编码 ]:
UN 3022 3/PG 2
[ WGK德国 ]:
2
[ RTECS号 ]:
EK3675000
[ 包装等级 ]:
II
[ 危险类别 ]:
3.1
[ 海关编码 ]:
2910900090
1,2-环氧丁烷合成路线
1,2-环氧丁烷上下游产品
1,2-环氧丁烷上游产品
1,2-环氧丁烷下游产品
1,2-环氧丁烷制备
工业上，环氧丁烷来源于环氧丙烷生产的副产品回收，在用裂解尾气经次氯酸化生产环氧乙烷、环氧丙烷过程中，可得环氧丙烷塔釜残液。其中含环氧丁烷74.6%，环氧丙烷16.7%，环氧乙烷0.7%，水3.1%，还有少量高沸物。通过蒸馏，从塔丁收集50-70℃的馏分，冷凝后除去水分，获得含量约87%的1,2-环氧丁烷成品，如需要更高纯度，则可进一步分馏。
1,2-环氧丁烷海关
[ 海关编码 ]: 2910900090
[ 中文概述 ]:
2910900090. 三节环环氧化物，环氧醇（酚，醚），包括其卤化，磺化，硝化或亚硝化的衍生物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%
1,2-环氧丁烷文献
Toxicology 323 , 70-7, (2014)
Trichloroethylene (TCE) is widely used as a cleaning and decreasing agent and has been shown to cause liver tumours in rodents and a small incidence of renal tubule tumours in male rats. The basis for...
Aqueous-phase aminolysis: approach for the analysis of epoxides in water.Anal. Chem. 78(8) , 2608-2616, (2006)
Trace concentrations of small soluble epoxides are suspected byproducts of drinking water ozonation. However, adequate characterization of epoxide formation is currently limited by the lack of suitabl...
Comparative mutagenicity of structurally related aliphatic epoxides in a modified Salmonella/microsome assay.Mutagenesis 8(5) , 387-93, (1993)
Four structurally related aliphatic epoxides (1,2-epoxypropane, 1,2-epoxyisobutane, cis- and trans-2,3-epoxybutane) have been tested in the Salmonella/microsome assay, modified for volatile substances...
相关化工产品/化学物质：
推荐生产厂家/供应商：
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥需询单/1mg
￥需询单/1mg
￥需询单/1g
￥需询单/1mg
联系人：阿拉丁李高志
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相关化合物
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