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3,4-环氧-1-丁烯

3,4-环氧-1-丁烯名称

[ CAS 号 ]:
930-22-3

[ 中文名 ]:
3,4-环氧-1-丁烯

[ 英文名 ]:
2-Vinyloxirane

[中文别名 ]:

[英文别名 ]:

2-Vinyloxirane
3,4-EPOXY-1-BUTENE
EINECS 213-210-4
Oxirane, 2-ethenyl-
2-ethenyloxirane
MFCD00005149
UNII:478ERR5NKR

3,4-环氧-1-丁烯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
70.0±9.0 °C at 760 mmHg

[ 熔点 ]:
-135ºC

[ 分子式 ]:
C₄H₆O

[ 分子量 ]:
70.090

[ 闪点 ]:
-50.0±0.0 °C

[ 精确质量 ]:
70.041862

[ PSA ]:
12.53000

[ LogP ]:
-0.03

[ 外观性状 ]:
液体;Colorless to Light orange to Yellow clear liquid to slightly cloudy liquid

[ 蒸汽压 ]:
142.6±0.1 mmHg at 25°C

[ 折射率 ]:
1.578

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
可溶于：乙醇,乙醚,苯

3,4-环氧-1-丁烯MSDS

3,4-环氧-1-丁烯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EM7350000

CHEMICAL NAME :: 1-Butene, 3,4-epoxy-

CAS REGISTRY NUMBER :: 930-22-3

LAST UPDATED :: 199801

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C4-H6-O

MOLECULAR WEIGHT :: 70.10

WISWESSER LINE NOTATION :: T3OTJ B1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 168 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 492 gm/kg/41W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Mutation in mammalian somatic cells

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 625 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 249,55,1991

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3,4-环氧-1-丁烯安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302-H319

[ 警示性声明 ]:
P210-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Highlyflammable;Xn:Harmful;

[ 风险声明 (欧洲) ]:
R11;R40

[ 安全声明 (欧洲) ]:
S16-S36/37-S45

[ 危险品运输编码 ]:
UN 1993 3/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
EM7350000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
2910900090

3,4-环氧-1-丁烯合成路线

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3,4-环氧-1-丁烯海关

[ 海关编码 ]: 2910900090

[ 中文概述 ]:
2910900090. 三节环环氧化物，环氧醇（酚，醚），包括其卤化，磺化，硝化或亚硝化的衍生物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

3,4-环氧-1-丁烯文献

In vivo doses of butadiene epoxides as estimated from in vitro enzyme kinetics by using cob(I)alamin and measured hemoglobin adducts: an inter-species extrapolation approach.

Toxicol. Appl. Pharmacol. 281(3) , 276-84, (2014)

1,3-Butadiene (BD) is a rodent and human carcinogen. In the cancer tests, mice have been much more susceptible than rats with regard to BD-induced carcinogenicity. The species-differences are dependen...

Mutagenicity of stereochemical configurations of 1,2-epoxybutene and 1,2:3,4-diepoxybutane in human lymphblastoid cells.

Chem. Biol. Interact. 166(1-3) , 207-18, (2007)

The carcinogenicity of 1,3-butadiene (BD) is related to its bioactivation to several DNA-reactive metabolites; accumulating evidence suggests that the stereochemistry of these BD intermediates may pla...

Dose responses for DNA adduct formation in tissues of rats and mice exposed by inhalation to low concentrations of 1,3-[2,3-[(14)C]-butadiene.

Chem. Biol. Interact. 147(2) , 195-211, (2004)

Male Sprague-Dawley rats and B6C3F1 mice were exposed to either a single 6h or a multiple (5) daily (6h) nose-only dose of 1,3-[2,3-(14)C]-butadiene at exposure concentrations of nominally 1, 5 or 20 ...

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