甲基异丁基甲醇(MIBC)
甲基异丁基甲醇(MIBC)用途
4-甲基-2-戊醇是优良的中沸点溶剂。主要用作染料、石油、橡胶、树脂、石蜡、硝基纤维素和乙基纤维素等的溶剂，用作硝化纤维素漆的惰性溶剂，可增加涂料的光泽和平整性，改进泛红性能；在润滑油添加剂制造中用作溶剂等。用于有机合成的原料，矿物浮选洗剂，如萃取硅和硫酸铜矿；还可用于刹车液。
甲基异丁基甲醇(MIBC)名称
[ CAS 号 ]:
108-11-2
[ 中文名 ]:
4-甲基-2-戊醇
[ 英文名 ]:
4-Methylpentan-2-ol
[中文别名 ]:
[英文别名 ]:
- FEMA 3351
- 3-HEXYL ALCOHOL
- EINECS 210-790-0
- dimethyl 2-butanol
- 4-Methyl-2-pentanol
- (±)-4-Methyl-2-pentanol
- DL-3-HEXANOL
- Metilamil alcohol
- MAOH
- 2-Pentanol, 4-methyl-
甲基异丁基甲醇(MIBC)物理化学性质
[ 密度 ]:
0.8±0.1 g/cm3
[ 沸点 ]:
133.5±8.0 °C at 760 mmHg
[ 熔点 ]:
-90 °C
[ 分子式 ]:
C6H14O
[ 分子量 ]:
102.175
[ 闪点 ]:
41.1±0.0 °C
[ 精确质量 ]:
102.104462
[ PSA ]:
20.23000
[ LogP ]:
1.57
[ 外观性状 ]:
一种透明无色液体带有一种温和气味
[ 蒸汽密度 ]:
3.5 (vs air)
[ 蒸汽压 ]:
3.7±0.5 mmHg at 25°C
[ 折射率 ]:
1.412
[ 储存条件 ]:
库房通风低温干燥,与氧化剂分开储运
[ 稳定性 ]:
Stable. Flammable. Incompatible with oxidizing agents, acids, acid chlorides.
[ 水溶解性 ]:
2 g/100 mL
甲基异丁基甲醇(MIBC)MSDS
甲基异丁基甲醇(MIBC)毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SA7350000
- CHEMICAL NAME :
- 2-Pentanol, 4-methyl-
- CAS REGISTRY NUMBER :
- 108-11-2
- BEILSTEIN REFERENCE NO. :
- 1098268
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 29
- MOLECULAR FORMULA :
- C6-H14-O
- MOLECULAR WEIGHT :
- 102.20
- WISWESSER LINE NOTATION :
- QY1&1Y1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2590 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2000 ppm/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 31,343,1949
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes
- REFERENCE :
- UCPHAQ University of California, Berkeley, Publications in Pharmacology. (Berkeley, CA) V.1-3, 1938-57. Discontinued. Volume(issue)/page/year: 2,217,1949
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 812 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583) Volume(issue)/page/year: -,7,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 3560 uL/kg
- REFERENCE :
- AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951 *** REVIEWS *** ACGIH TLV-STEL 167 mg/m3 (40 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 104 mg/m3 (25 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 25 ppm (100 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,166,1971 OSHA PEL (Gen Indu):8H TWA 25 ppm (100 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 25 ppm (100 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 25 ppm (100 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 25 ppm (100 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 25 ppm (100 mg/m3);STEL 40 ppm;Skin JAN 1993 OEL-BELGIUM:TWA 25 ppm (104 mg/m3);STEL 40 ppm (166 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 25 ppm (100 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 25 ppm (100 mg/m3);STEL 40 ppm (170 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 25 ppm (100 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 25 ppm (100 mg/m3);Skin JAN 1993 OEL-RUSSIA:STEL 10 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 25 ppm (100 mg/m3);STEL 125 ppm;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 25 ppm (100 mg/m3);STEL 40 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO THE CHEMICAL-air:10H TWA 25 ppm (Sk);STEL 40 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3241 No. of Facilities: 2585 (estimated) No. of Industries: 31 No. of Occupations: 33 No. of Employees: 26405 (estimated) No. of Female Employees: 2882 (estimated)
甲基异丁基甲醇(MIBC)安全信息
[ 符号 ]:
GHS02, GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H226-H319-H335
[ 警示性声明 ]:
P210-P305 + P351 + P338-P370 + P378
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
Xi:Irritant;
[ 风险声明 (欧洲) ]:
R10;R37
[ 安全声明 (欧洲) ]:
S24/25
[ 危险品运输编码 ]:
UN 2282 3/PG 3
[ WGK德国 ]:
1
[ RTECS号 ]:
SA7350000
[ 包装等级 ]:
III
[ 危险类别 ]:
3
[ 海关编码 ]:
29051900
甲基异丁基甲醇(MIBC)合成路线
甲基异丁基甲醇(MIBC)上下游产品
甲基异丁基甲醇(MIBC)上游产品
甲基异丁基甲醇(MIBC)下游产品
甲基异丁基甲醇(MIBC)制备
先由丙酮在碱性催化剂存在下，加压缩合转化成二丙酮醇（见11360）。使用的催化剂为氢氧化钙或氢氧化钡。当催化剂粒子很小、表面积很大时，这一液相接触反应接近于均相反应。反应过程放出热量，低温下平衡转化率大。因此，原料丙酮要预冷，反应在0-10℃下操作。然后，二丙酮醇脱水生成异丙叉丙酮。过程获得的二两样酮醇，一般含量为10-15%，采用常压蒸馏浓缩至80%，同时分离和回收未转化的丙酮。在硝酸、硼酸或苯磺酸等酸性催化剂存在下，加热至100-200℃，二丙酮醇脱水生成异丙叉丙酮，转化率为80-85%。但二丙酮醇能受热分解成丙酮，因此脱水产物需回收基中的丙酮。最后上步反应是异丙叉两样酮加氢生成4-甲基-2-戊醇。实际上，如果以镍或铜为催化剂，气相加氢在常压下进行的条件比较温和时，则得到较多的部分加氢产物甲基异丁基甲酮。当温度控制为170-210℃，氢与异丙叉丙酮的摩尔配比加大时，则较多获得完全加氢产物甲基异丁基甲醇。而一般情况下得到的是两者混合物，精馏分离时采用减压蒸馏系统。也可以甲基-异丁基（甲）酮经镍催化加氢制成，经精馏塔分馏，得成品。
甲基异丁基甲醇(MIBC)海关
[ 海关编码 ]: 2905199090
[ 中文概述 ]:
2905199090. 其他饱和一元醇. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 包装
[ Summary ]:
2905199090. saturated monohydric alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%
甲基异丁基甲醇(MIBC)文献
Bioorg. Med. Chem. 17 , 896-904, (2009)
This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...
Optimal design of experiments applied to headspace solid phase microextraction for the quantification of vicinal diketones in beer through gas chromatography-mass spectrometric detection.Anal. Chim. Acta 887 , 101-10, (2015)
Vicinal diketones, namely diacetyl (DC) and pentanedione (PN), are compounds naturally found in beer that play a key role in the definition of its aroma. In lager beer, they are responsible for off-fl...
Activation of EZH2 and SUZ12 Regulated by E2F1 Predicts the Disease Progression and Aggressive Characteristics of Bladder Cancer.Clin. Cancer Res. 21 , 5391-403, (2015)
Previous study identified E2F1 as a key mediator of non-muscle-invasive bladder cancer (NMIBC) progression. The aim of this study was to identify the E2F1-related genes associated with poor prognosis ...
相关化工产品/化学物质：
推荐生产厂家/供应商：
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥108.0/500ml
联系人：刘佳
产品详情：4-甲基-2-戊醇
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥需询单/1mg
￥需询单/1mg
￥需询单/1mg
￥需询单/1g
联系人：阿拉丁李高志
产品详情：甲基异丁基甲醇（MIBC）
公司名：济南世纪通达化工有限公司
区域：济南市天桥区
价格：
￥26500.0/1ton
￥52000.0/2ton
联系人：王经理
产品详情：甲基异丁基甲醇（MIBC）
公司名：山东金悦源新材料有限公司
区域：济南市天桥区
价格：
￥18000.0/1ton
联系人：王思兵
产品详情：甲基异丁基甲醇
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相关化合物
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