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异丙醇

异丙醇用途

【用途一】
主要用于制药,也用作溶剂、萃取剂、防冻剂等
【用途二】
用作实验用化学试剂及色谱分析试剂
【用途三】
异丙醇是农药生产的重要中间体,可以生产杀菌剂稻瘟灵、异稻瘟净等,杀虫杀螨剂胺丙畏、水胺硫磷、甲基异柳磷、残杀威、氰戊菊酯等,以及除草剂异丙草胺,并可制备溴代异丙烷和氯代异丙烷,也是农药的重要中间体。
【用途四】
萃取溶剂,载体溶剂。GB 2760-1996:暂时允许使用的食品用香料。用于甜菜糖、糖果、营养增补片剂、酒花萃取、柠檬油、香辛料油树脂、酵母等加工。
【用途五】
作为有机原料和溶剂有着广泛用途。作为化工原料,可生产丙酮、过氧化氢、甲基异丁基酮、二异丁基酮、异丙胺、异丙醚、异丙醇醚、异丙基氯化物,以及脂肪酸异丙酯和氯代脂肪酸异丙酯等。在精细化工方面,可用于生产硝酸异丙酯,黄原酸异丙酯、亚磷酸三异丙酯、三异丙醇铝以及医药和农药等。作为溶剂,可用于生产涂料、油墨、萃取剂、气溶胶剂等。还可用作防冻剂、清洁剂、调和汽油的添加剂、颜料生产的分散剂、印染工业的固定剂、玻璃和透明塑料的防雾剂等。
【用途六】
杂酚油、虫胶、树脂、树胶、硝基纤维素的溶剂。酯化分析测定植物油的溶剂, 测定钡、钙、铜、镁、镍、钾、钠及锶。亚硝酸钴钠-异丙醇法测定土壤及植株含钾量,萃取生物碱,农药分析等。有机合成。抗冻液组合。
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异丙醇名称

[ CAS 号 ]:
67-63-0

[ 中文名 ]:
异丙醇

[ 英文名 ]:
Isopropanol

[中文别名 ]:

[英文别名 ]:

异丙醇物理化学性质

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
73.0±3.0 °C at 760 mmHg

[ 熔点 ]:
-89.5 °C

[ 分子式 ]:
C3H8O

[ 分子量 ]:
60.095

[ 闪点 ]:
11.7±0.0 °C

[ 精确质量 ]:
60.057514

[ PSA ]:
20.23000

[ LogP ]:
0.16

[ 外观性状 ]:
无色液体

[ 蒸汽密度 ]:
2.1 (vs air)

[ 蒸汽压 ]:
81.3±0.2 mmHg at 25°C

[ 折射率 ]:
1.376

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 水溶解性 ]:
miscible

[ 凝固点 ]:
-89.5℃

异丙醇MSDS

异丙醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NT8050000
CHEMICAL NAME :
Isopropyl alcohol
CAS REGISTRY NUMBER :
67-63-0
BEILSTEIN REFERENCE NO. :
0635639
LAST UPDATED :
199712
DATA ITEMS CITED :
90
MOLECULAR FORMULA :
C3-H8-O
MOLECULAR WEIGHT :
60.11
WISWESSER LINE NOTATION :
QY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
14432 mg/kg
TOXIC EFFECTS :
Behavioral - coma Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
223 mg/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions Cardiac - pulse rate Vascular - BP lowering not characterized in autonomic section
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
5272 mg/kg
TOXIC EFFECTS :
Behavioral - coma Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - chronic pulmonary edema
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
3570 mg/kg
TOXIC EFFECTS :
Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - nausea or vomiting
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - infant
DOSE/DURATION :
13 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - irritability Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
2770 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - infant
DOSE/DURATION :
1375 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Behavioral - hallucinations, distorted perceptions
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5045 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
16000 ppm/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2735 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1088 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3600 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12800 ppm/3H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4477 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1509 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1537 mg/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1024 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
6 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
1963 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
6410 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
12800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
667 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1184 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2560 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
3444 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
20 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
6 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - general anesthetic Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7 mL/kg/7D-I
TOXIC EFFECTS :
Liver - other changes Biochemical - Effect on specific coenzyme - B vitamins including folate
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 mg/m3/4H/17W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8000 ppm/8H/20W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory change involving peripheral nerve Peripheral Nerve and Sensation - recording from peripheral motor nerve
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5000 ppm/6H/90D-I
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2500 ppm/6H/2Y-I
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - changes in bladder weight
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10000 ppm/6H/11D-I
TOXIC EFFECTS :
Behavioral - general anesthetic Behavioral - ataxia Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5000 ppm/6H/13W-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Liver - changes in liver weight Blood - pigmented or nucleated red blood cells
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5000 ppm/6H/13W-I
TOXIC EFFECTS :
Behavioral - general anesthetic Behavioral - ataxia Liver - changes in liver weight
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5000 ppm/6H/78W-I
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
11340 mg/kg
SEX/DURATION :
female 45 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5040 mg/kg
SEX/DURATION :
female 1-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
8 gm/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
32400 ug/kg
SEX/DURATION :
female 26 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3500 gm/kg
SEX/DURATION :
multigeneration
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
3500 ppm/7H
SEX/DURATION :
female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
10000 ppm/7H
SEX/DURATION :
female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
7000 ppm/7H
SEX/DURATION :
female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6240 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects

MUTATION DATA

TEST SYSTEM :
Rodent - rat
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 25(7),33,1981 *** REVIEWS *** ACGIH TLV-STEL 1230 mg/m3 (500 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 983 mg/m3 (400 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,223,1977 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,229,1987 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,229,1987 TOXICOLOGY REVIEW JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 20,428,1938 TOXICOLOGY REVIEW CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955- Volume(issue)/page/year: 19,361,1973 TOXICOLOGY REVIEW FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub lisher information, see FSINDR. Volume(issue)/page/year: 2,67,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 400 ppm (980 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,141,1971 OSHA PEL (Gen Indu):8H TWA 400 ppm (980 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 400 ppm (980 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 400 ppm (980 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 400 ppm (980 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 400 ppm (980 mg/m3);STEL 500 ppm (1225 mg/m3) JAN 1993 OEL-BELGIUM:TWA 400 ppm (985 mg/m3);STEL 500 ppm (1230 mg/m3) JAN 1993 OEL-DENMARK:TWA 200 ppm (490 mg/m3);Skin JAN 1993 OEL-FRANCE:STEL 400 ppm (980 mg/m3) JAN 1993 OEL-GERMANY:TWA 400 ppm (980 mg/m3) JAN 1993 OEL-JAPAN:STEL 400 ppm (980 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 400 ppm (980 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 400 ppm (980 mg/m3) JAN 1993 OEL-RUSSIA:STEL 400 ppm (10 mg/m3) JAN 1993 OEL-SWEDEN:TWA 150 ppm (350 mg/m3);STEL 250 ppm (600 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 400 ppm (980 mg/m3);STEL 800 ppm JAN 1993 OEL-TURKEY:TWA 200 ppm (500 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 400 ppm (980 mg/m3);STEL 500 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ISOPROPYL ALCOHOL-air:10H TWA 400 ppm;STEL 500 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 40987 No. of Facilities: 213605 (estimated) No. of Industries: 465 No. of Occupations: 252 No. of Employees: 3183554 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 40987 No. of Facilities: 183402 (estimated) No. of Industries: 449 No. of Occupations: 278 No. of Employees: 4665524 (estimated) No. of Female Employees: 2058264 (estimated)
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异丙醇安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319-H336

[ 警示性声明 ]:
P210-P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
11-36-67-40-10-36/38

[ 安全声明 (欧洲) ]:
S7-S16-S24/25-S26-S36/37

[ 危险品运输编码 ]:
UN 1219 3/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
NT8050000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
2905122000

异丙醇合成路线

异丙醇上下游产品

异丙醇制备

1.间接水合法:将含丙稀50%以上的原料气通入吸收塔,在50℃和低压下用75%-85%的浓硫酸进行吸收反应,生成硫酸氢异丙酯。加水将吸收液稀释到硫酸含量为35%后,在解吸塔中用低压蒸汽将硫酸氢异丙酯水解成异丙醇。经粗蒸塔馏到异丙醇与水的共沸组成,含异丙醇87%左右。再继续用蒸馏塔蒸浓到95%,用苯萃取、分离水后再蒸馏,可得含异丙醇99%以上的成品。

该法特点是对丙烯的纯度要求不高,而且丙烯转化率可达50%-60%,可减少精制费用。但耗用硫酸量大,而且存在设备腐蚀和40%的废硫酸的浓问题。

2.直接水合法:将丙烯和水分别加压到1.96MPa,并预热到200℃,混合后加入反应器,进行水合反应.反应器内装有磷酸硅藻土催化剂,反应温度为95℃,压力为0.96MPa,水与丙烯的摩尔比为0.7:1,丙烯的单程转化率为5.2%,选择性为99%。反应气体经中和换热后送到高压冷却器和高压分离器,气相中的异丙醇在回收塔中用脱离子水喷淋回收,末反应的气体经循环压缩机加压后循环使用(保持循环系统中丙烯含量85%)。液相为低浓度异丙醇(15%-17%),经粗蒸塔蒸馏得85%-87%的异丙醇水溶液,再经蒸馏塔蒸浓到95%,然后用苯萃取提浓到99%以上。

与丙烯硫酸水合法相比,本法不用硫酸,不存在腐蚀设备问题,工艺流程简单;但丙烯单程转化率低,丙烯循环量太大,而且要求原料丙烯纯度达99.5%。为了克服丙烯直接水合法的缺点,以95%的丙烯为原料,反应温度240-270℃,反应压力14.7-19.6MPa,水与丙烯的摩尔为水过量。丙烯转化率为60%-70%,异丙醇选择性为99%,异丙烯精馏制后纯度可达99.9%以上,副产物为二异丙醚。此外,采用分子筛催化丙烯水合制异丙醇也是非常有前途的改进工艺方法。

3.将含丙烯50%以上的原料气,在50℃和低压下用75%~85%的浓硫酸进行吸收反应,生成硫酸氢异丙酯。再将硫酸氢异丙酯水解成异丙醇。经粗蒸用蒸馏塔蒸浓到95%,再用苯萃取、分离水后再蒸馏,可得含异丙醇99%以上的成品。或者将丙烯和水分别加压到1.96MPa,并预热到200℃,混合后加入反应器,进行水合反应。反应气体经中和换热后送到高压冷却器和高压分离器,气相中的异丙醇在回收塔中用脱离子水喷淋回收,经粗蒸塔蒸馏得85%~87%的异丙醇水溶液,再经蒸馏塔蒸浓到95%,然后用苯萃取得99%以上的异丙醇。

4.以工业品异丙醇为原料,在每升原料中加入200g新鲜的氧化钙,进行回流,数小时后蒸馏,以除去大部分水,然后在所收集的馏出液中加入氢化钙、氧化钡、钙、无水硫酸铜或5A分子筛,充分振后,静置48h,分出固体干燥剂后蒸馏,即可得纯品。

5.以95%的丙烯和过量水为原料,在钨系催化剂(如硅酸钨)存在下,于240~270℃,14.7~19.6MPa条件下进行反应:

所得异丙醇,精制后纯度可达99.9%以上。

6.先将过量的丙烯和水分别加压至2MPa ,预热至200℃。然后混合,送入反应器反应,催化剂为磷酸硅藻土。控制反应温度195℃,压力维持2MPa,反应结束后,气体先经中和然后进行高压冷却冷凝并气液分离,未反应气体,可循环使用。所得液体为浓度较低的粗异丙醇。经二次蒸馏浓度达95%,然后用苯萃取提浓可达99%以上。

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异丙醇海关

[ 海关编码 ]: 2905122000

异丙醇文献

Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation.

Retrovirology 11 , 118, (2015)

Down-modulation of the CD4 receptor is one of the hallmarks of HIV-1 infection and it is believed to confer a selective replicative advantage to the virus in vivo. This process is mainly mediated by t...

Comparative in vitro study on magnetic iron oxide nanoparticles for MRI tracking of adipose tissue-derived progenitor cells.

PLoS ONE 9(9) , e108055, (2014)

Magnetic resonance imaging (MRI) using measurement of the transverse relaxation time (R2*) is to be considered as a promising approach for cell tracking experiments to evaluate the fate of transplante...

Comparison of the antifungal efficacy of terbinafine hydrochloride and ciclopirox olamine containing formulations against the dermatophyte Trichophyton rubrum in an infected nail plate model.

Mol. Pharm. 11(7) , 1991-6, (2014)

Onychomycosis is a fungal infection mostly induced by dermatophytes such as Trichophyton rubrum. Due to slow nail growth, the treatment takes 3-9 months depending on the nail size and infected area. H...


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异丙醇是什么?

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异丙醇(Iso-Propyl Alcohol,IPA),又名二甲基甲醇、2-丙醇,也称IPA,是一种有机化合物。常温下以液体形态存在,无色透明,气味类似乙醇(俗称酒精)。其化学结构式为C3H8O,相对分子量为60.095,Cas号67-63-0,熔点(闪点11.7摄氏度),据化源网资料显示,异丙醇...


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【异丙醇】化源网提供异丙醇CAS号67-63-0,异丙醇MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询异丙醇上化源网,专业又轻松。>>电脑版:异丙醇

标题:异丙醇_MSDS_用途_密度_异丙醇CAS号【67-63-0】_化源网 地址:https://m.chemsrc.com/mip/cas/67-63-0_766167.html