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二乙胺

二乙胺用途

【用途一】
用作医药、农药的中间体及橡胶促进剂
【用途二】
用作分析试剂和防腐剂，也用于有机合成及染料的制造
【用途三】
二乙胺是杀虫剂磷胺、嘧啶磷和除草剂禾草丹、敌草胺的中间体。
【用途四】
二乙胺为溶剂和化工原料中间体，可制取药物普鲁卡因、氯喹、尼可刹米、可拉明及磺胺等类药，也可用于生产农药、染料、橡胶硫化促进剂、选矿药剂（硫氮9号）、纺织助剂、杀菌剂、缓蚀剂、阻聚剂和抗冻剂等。需消耗二乙胺的医药产品及其二乙胺的消耗量：头孢唑啉钠0.789kg/kg、头孢拉啶0.059kg/kg、合成黄连素0.030kg/kg、磺胺嘧啶0.150kg/kg、磷酸氯喹0.340kg/kg、咳必清0.710kg/kg、灭吐灵0.960kg/kg、止血敏0.660kg/kg、盐酸普鲁卡因0.600kg/kg、盐酸利多卡因0.890kg/kg。
【用途五】
检定锑、铂和锡，测定二硫化碳和镁，有机合成。二乙胺为溶剂和化工原料中间体，可制取药物普鲁卡因、氯喹、尼可刹米、可拉明及磺胺等类药，也可用于生产农药、染料、橡胶硫化促进剂、选矿药剂（硫氮9号）；纺织助剂、杀菌剂、缓蚀剂、阻聚剂和抗冻剂等。
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二乙胺名称

[ CAS 号 ]:
109-89-7

[ 中文名 ]:
二乙胺

[ 英文名 ]:
Diethylamine

[中文别名 ]:

[英文别名 ]:

二乙胺物理化学性质

[ 密度 ]:
0.7±0.1 g/cm3

[ 沸点 ]:
57.3±8.0 °C at 760 mmHg

[ 熔点 ]:
-50 °C

[ 分子式 ]:
C4H11N

[ 分子量 ]:
73.137

[ 闪点 ]:
-28.9±0.0 °C

[ 精确质量 ]:
73.089149

[ PSA ]:
12.03000

[ LogP ]:
0.63

[ 外观性状 ]:
透明至略淡黄色液体

[ 蒸汽密度 ]:
2.5 (vs air)

[ 蒸汽压 ]:
218.4±0.1 mmHg at 25°C

[ 折射率 ]:
1.384

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 稳定性 ]:
Stable. Highly flammable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
soluble

二乙胺MSDS

详细MSDS(安全技术说明书)

二乙胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HZ8750000
CHEMICAL NAME :
Diethylamine
CAS REGISTRY NUMBER :
109-89-7
LAST UPDATED :
199806
DATA ITEMS CITED :
52
MOLECULAR FORMULA :
C4-H11-N
MOLECULAR WEIGHT :
73.16
WISWESSER LINE NOTATION :
2M2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
540 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Behavioral - sleep Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 gm/m3/2H
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Lungs, Thorax, or Respiration - acute pulmonary edema Liver - fatty liver degeneration
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
585 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
20 gm/m3
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - emphysema Liver - fatty liver degeneration
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
820 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
5000 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4994 mg/kg/11W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
250 ppm/6H/24W-I
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4 mg/m3/24H/93D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Microorganism - not otherwise specified
REFERENCE :
EJMBA2 Egyptian Journal of Microbiology. (National Information and Documentation Centre, A1-Tahrir St., Awqaf P.O. Dokki, Cairo, Egypt) V.7- 1972- Volume(issue)/page/year: 15,113,1980 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 45 mg/m3 (15 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 15 mg/m3 (5 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 9,389,1931 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 25 ppm (75 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,84,1971 OSHA PEL (Gen Indu):8H TWA 25 ppm (75 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 25 ppm (75 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 25 ppm (75 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 25 ppm (75 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (30 mg/m3);STEL 25 ppm (75 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 10 ppm (30 mg/m3) JAN 1993 OEL-BELGIUM:TWA 10 ppm (30 mg/m3);STEL 25 ppm (75 mg/m3) JAN 1993 OEL-DENMARK:TWA 10 ppm (30 mg/m3) JAN 1993 OEL-FINLAND:STEL 10 ppm (30 mg/m3);Skin JAN 1993 OEL-FRANCE:STEL 10 ppm (30 mg/m3) JAN 1993 OEL-GERMANY:TWA 10 ppm (30 mg/m3) JAN 1993 OEL-HUNGARY:TWA 30 mg/m3;STEL 60 mg/m3 JAN 1993 OEL-JAPAN:TWA 10 ppm (30 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 10 ppm (30 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 25 ppm (75 mg/m3) JAN 1993 OEL-POLAND:TWA 30 mg/m3 JAN 1993 OEL-RUSSIA:TWA 10 ppm;STEL 30 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 10 ppm (30 mg/m3);STEL 15 ppm (45 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 10 ppm (30 mg/m3);STEL 20 ppm (60 mg/m3) JAN 1993 OEL-TURKEY:TWA 25 ppm (75 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (30 mg/m3);STEL 25 ppm (75 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIETHYLAMINE-air:10H TWA 10 ppm;STEL 25 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 24680 No. of Facilities: 2138 (estimated) No. of Industries: 20 No. of Occupations: 28 No. of Employees: 34647 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 24680 No. of Facilities: 1387 (estimated) No. of Industries: 22 No. of Occupations: 24 No. of Employees: 28361 (estimated) No. of Female Employees: 6878 (estimated)
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二乙胺安全信息

[ 符号 ]:

GHS02, GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302 + H332-H311-H314

[ 警示性声明 ]:
P210-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P370 + P378

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R11;R20/21/22;R35

[ 安全声明 (欧洲) ]:
S16-S26-S29-S36/37/39-S45-S3

[ 危险品运输编码 ]:
UN 1154 3/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
HZ8750000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
2921199090

二乙胺合成路线

详细合成路线

二乙胺上下游产品

二乙胺上游产品

二乙胺下游产品

二乙胺制备

1.乙醇常压气相催化法将气相乙醇、氨和氢以1：0.8：1.5（mol）混合，经预热（170-180℃）进入装有铜镍催化剂的第一反应器，于195-200℃下进行气相催化反应，然后再进入有铜镍催化剂的第二反应器进行合成反应，于170-175℃下进行还原，以除去乙腈等杂质。将反应气经冷凝后收得一、二、三乙胺、乙醇等混合液，再经粗馏、精馏、切取54-57℃馏分为二乙胺成品。其含量可达95%以上，同时可得少量三乙胺。

2.氯乙烷与氨（氨水）在氢氧化钙水溶液中，于压力2.26MPa，温度135℃左右反应6h，然后加入氢氧化钠破坏二乙胺氯化钙复盐的生成，最后经蒸馏、精馏，切取55-57℃馏分为二乙胺成品，含量达98%以上，收率80%，同时可得少量三乙胺。

3.乙腈氢化、氨化法。

4.乙醛氢化、氨化法。

5.二乙基苯胺法。

6.其制备方法是用乙醇、氨和氢的混合气，经预热，温度为180℃左右，在镍一铜催化剂作用下，依次进入第一转化器(温度200℃左右)、第二转化器(温度80℃左右)进行合成反应，反应产物经粗馏、精馏得成品。

精制方法：常含有乙胺、三乙胺、乙醛等杂质。可用分馏的方法进行精制。馏出物用固体氢氧化钾脱水后，再用芴酮钠干燥备用。或在金属钠存在下加热回流2小时后再分馏精制。也可将二乙胺转变成盐酸盐，再用干燥的石油醚反复进行重结晶，直到熔点达223.5℃时为止。加氢氧化钾将二乙胺游离出来，再经干燥，蒸馏得纯品。

7.乙醇常压气相催化法，反应可得一乙胺、二乙胺、三乙胺、乙醇等混合液，再经粗馏、精馏、收集二乙胺馏分即可。或者氯乙烷与氨（氨水）在氢氧化钙水溶液中于一定温度和压力下反应，最后经蒸馏、精馏即可。
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二乙胺海关

[ 海关编码 ]: 2921199090

[ 中文概述 ]:
2921199090 其他无环单胺及其衍生物及其盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

二乙胺文献

Controlled Endolysosomal Release of Agents by pH-responsive Polymer Blend Particles.

Pharm. Res. 32 , 2280-91, (2015)

A key step of delivering extracellular agents to its intracellular target is to escape from endosomal/lysosomal compartments, while minimizing the release of digestive enzymes that may compromise cell...

Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins

Bioorg. Med. Chem. 17 , 896-904, (2009)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...

Magnetic high throughput screening system for the development of nano-sized molecularly imprinted polymers for controlled delivery of curcumin.

Analyst 140(9) , 3113-20, (2015)

Curcumin is a versatile anti-inflammatory and anti-cancer agent known for its low bioavailability, which could be improved by developing materials capable of binding and releasing drug in a controlled...


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【二乙胺】化源网提供二乙胺CAS号109-89-7，二乙胺MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询二乙胺上化源网，专业又轻松。>>电脑版：二乙胺

标题：二乙胺_MSDS_用途_密度_二乙胺CAS号【109-89-7】_化源网 地址：https://m.chemsrc.com/mip/cas/109-89-7_57937.html