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盐酸乙丙嗪

盐酸乙丙嗪用途

盐酸乙氧丙嗪(异恶嗪)是一种有效的选择性BChE抑制剂,也是一种较差的乙酰胆碱酯酶抑制剂。盐酸乙氧丙嗪是一种具有抗胆碱能特性的吩噻嗪化合物。盐酸乙氧丙嗪可用于帕金森病的研究[1][2]。

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盐酸乙丙嗪名称

[ CAS 号 ]:
1094-08-2

[ 中文名 ]:
盐酸乙丙嗪

[ 英文名 ]:
10-[2-DIETHYLAMINOPROPYL]PHENOTHIAZINE

[中文别名 ]:

爱普把嗪

[英文别名 ]:

isothazinehydrochloride
ProphenamineHCl
parsidolhydrochloride
EINECS 214-134-4
ethopropazine hydrochloride
Profenaminhydrochlorid
10-[2-DIETHYLAMINOPROPYL]PHENOTHIAZINE
parfezin
lysivanehydrochloride
ethopropazine hcl

盐酸乙丙嗪生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> 疼痛

[ 靶点 ]

BChE, AChE[2]

[参考文献]

[1]. Prabhu S, et al. Enhancement of dissolution of ethopropazine using solid dispersions prepared with phospholipid and/or polyethylene glycol. Drug Dev Ind Pharm. 2001 May;27(5):413-8.

[2]. Reiner E, et al. Activity of cholinesterases in human whole blood measured with acetylthiocholine as substrate and ethopropazine as selective inhibitor of plasma butyrylcholinesterase. Arh Hig Rada Toksikol. 2004 Apr;55(1):1-4.

盐酸乙丙嗪物理化学性质

[ 沸点 ]:
430.1ºC at 760 mmHg

[ 熔点 ]:
225 - 228 °C

[ 分子式 ]:
C₁₉H₂₅ClN₂S

[ 分子量 ]:
348.93300

[ 闪点 ]:
213.9ºC

[ 精确质量 ]:
348.14300

[ PSA ]:
31.78000

[ LogP ]:
5.88660

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
1.34E-07mmHg at 25°C

[ 储存条件 ]:
2-8°C

盐酸乙丙嗪MSDS

详细MSDS(安全技术说明书)

盐酸乙丙嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO5002000

CHEMICAL NAME :: Phenothiazine, 10-(2-(diethylamino)propyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 1094-08-2

LAST UPDATED :: 199706

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C19-H24-N2-S.Cl-H

MOLECULAR WEIGHT :: 348.97

WISWESSER LINE NOTATION :: T C666 BN ISJ BY1&1N2&2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1041,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 390 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1041,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1041,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 88,713,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1041,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 670 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - hematuria

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 14,559,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00853

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盐酸乙丙嗪安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
SO5002000

盐酸乙丙嗪文献

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Linking a compound-heterozygous Parkin mutant (Q311R and A371T) to Parkinson's disease by using proteomic and molecular approaches.

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