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糠酸; 2-糠酸; 2-呋喃甲酸

糠酸; 2-糠酸; 2-呋喃甲酸用途

2-Furoic acid (Furan-2-carboxylic acid) 是一种有机化合物,经糠醛氧化得到。在大鼠试验中,2-Furoic acid 具有抗血脂作用,能够降低血清中胆固醇和甘油三酯的水平。

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糠酸; 2-糠酸; 2-呋喃甲酸名称

[ CAS 号 ]:
88-14-2

[ 中文名 ]:
糠酸

[ 英文名 ]:
Furan-2-carboxylic acid

[中文别名 ]:

[英文别名 ]:

2-furanyl-carboxylic acid
pyromucic acid
Furan-2-carboxylic acid
2-FURANCARBONYL CHLORIDE
2-Furoic acid
a-Furoicacid
Kyselina 2-furoova
2- FUROIC ACID
2-FUROIC ACID/FURAN-2-CARBOXYLIC ACID
Furoica

糠酸; 2-糠酸; 2-呋喃甲酸生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 酰基转移酶

信号通路 >> 代谢酶/蛋白酶 >> ATP柠檬酸裂解酶

研究领域 >> 代谢疾病

[体内研究]

2-糠酸显着降低血清胆固醇和血清甘油三酯水平[2]。 2-糠酸还可降低肝脏和小肠ATP依赖性柠檬酸裂解酶,乙酰辅酶A合成酶,酰基辅酶A胆固醇酰基转移酶,sn-甘油3-磷酸酰基转移酶,磷脂酰磷酸水解酶和肝素诱导的脂蛋白脂酶活性[2]。在小鼠的急性毒性研究中,2-糠酸显示出250mg/kg ip的LD50 [2]。

[参考文献]

[1]. Wordofa GG, et al. Tolerance and metabolic response of Pseudomonas taiwanensis VLB120 towards biomass hydrolysate-derived inhibitors. Biotechnol Biofuels. 2018 Jul 19;11:199.

[2]. Hall IH, et al. The hypolipidemic effects of 2-furoic acid in Sprague-Dawley rats. Arch Pharm (Weinheim). 1993 Jan;326(1):15-23.

[相关活性小分子]

糠酸; 2-糠酸; 2-呋喃甲酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
230-232 ºC

[ 熔点 ]:
129-133 ºC

[ 分子式 ]:
C₅H₄O₃

[ 分子量 ]:
112.084

[ 闪点 ]:
137 ºC

[ 精确质量 ]:
112.016045

[ PSA ]:
50.44000

[ LogP ]:
0.64

[ 外观性状 ]:
白色至淡黄色晶体粉末

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.513

[ 储存条件 ]:
室温

[ 水溶解性 ]:
36 g/L (20 ºC)

糠酸; 2-糠酸; 2-呋喃甲酸MSDS

详细MSDS(安全技术说明书)

糠酸; 2-糠酸; 2-呋喃甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV1763000

CHEMICAL NAME :: 2-Furoic acid

CAS REGISTRY NUMBER :: 88-14-2

BEILSTEIN REFERENCE NO. :: 0110149

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C5-H4-O3

MOLECULAR WEIGHT :: 112.09

WISWESSER LINE NOTATION :: T5OJ BVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 10 ug/plate

REFERENCE :: JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 1,15,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1977 No. of Facilities: 6 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 774 (estimated) No. of Female Employees: 10 (estimated)

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糠酸; 2-糠酸; 2-呋喃甲酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
C;Xi

[ 风险声明 (欧洲) ]:
R34;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S36

[ 危险品运输编码 ]:
UN 3265 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
LV1763000

[ 海关编码 ]:
29321900

糠酸; 2-糠酸; 2-呋喃甲酸合成路线

详细合成路线

糠酸; 2-糠酸; 2-呋喃甲酸上下游产品

糠酸; 2-糠酸; 2-呋喃甲酸上游产品

糠酸; 2-糠酸; 2-呋喃甲酸下游产品

糠酸; 2-糠酸; 2-呋喃甲酸制备

1.由糖醛经空气氧化而得。反应在45℃，强烈搅拌下进行。将反应物过滤回收催化剂氧化铜，滤液用50%硫酸酸化至pH为3-2.5，吸滤，水洗，烘干即得糠酸。将糠醛在中性或碱性介质中，用次氯酸钠或高锰酸钾氧化2h，再用盐酸酸化，也可制得糠酸，收率右达98%。

2. 烟草：OR，44；FC，9；OR，26；BU，26。

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糠酸; 2-糠酸; 2-呋喃甲酸海关

[ 海关编码 ]: 2932190090

[ 中文概述 ]:
2932190090 其他结构上有非稠合呋喃环化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

糠酸; 2-糠酸; 2-呋喃甲酸文献

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...

Optimization and Kinetic Studies on Biodiesel Production from Kusum (Schleichera triguga) Oil Using Response Surface Methodology.

J. Oleo Sci. 64 , 987-97, (2015)

In the present study, the low-cost non-edible kusum (Schleichera triguga) oil with a substantial amount of free fatty acid (FFA) was utilized for biodiesel synthesis. In pretreatment step, FFA was red...

High tolerance and physiological mechanism of Zymomonas mobilis to phenolic inhibitors in ethanol fermentation of corncob residue.

Biotechnol. Bioeng. 112 , 1770-82, (2015)

Corncob residue as the lignocellulosic biomass accumulated phenolic compounds generated from xylitol production industry. For utilization of this biomass, Zymomonas mobilis ZM4 was tested as the ethan...

更多文献

糠酸; 2-糠酸; 2-呋喃甲酸

糠酸; 2-糠酸; 2-呋喃甲酸用途

糠酸; 2-糠酸; 2-呋喃甲酸名称

糠酸; 2-糠酸; 2-呋喃甲酸生物活性

糠酸; 2-糠酸; 2-呋喃甲酸物理化学性质

糠酸; 2-糠酸; 2-呋喃甲酸MSDS

详细MSDS(安全技术说明书)

糠酸; 2-糠酸; 2-呋喃甲酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

糠酸; 2-糠酸; 2-呋喃甲酸安全信息

糠酸; 2-糠酸; 2-呋喃甲酸合成路线

详细合成路线

糠酸; 2-糠酸; 2-呋喃甲酸上下游产品

糠酸; 2-糠酸; 2-呋喃甲酸上游产品

糠酸; 2-糠酸; 2-呋喃甲酸下游产品

糠酸; 2-糠酸; 2-呋喃甲酸制备

糠酸; 2-糠酸; 2-呋喃甲酸海关

糠酸; 2-糠酸; 2-呋喃甲酸文献

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