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维吉尼霉素

维吉尼霉素用途

维吉尼亚霉素复合物包含两种链霉素抗生素,维吉尼亚霉素M1和维吉尼亚霉素S1。作为一种复合物,这两种抗生素协同作用,不可逆地抑制细菌中的蛋白质合成[1]。

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维吉尼霉素名称

[ CAS 号 ]:
11006-76-1

[ 中文名 ]:
维吉尼霉素

[ 英文名 ]:
Virginiamycin

[中文别名 ]:

[英文别名 ]:

Lactrol
VirginiamycinnnDISCONTINUED
patricin
eskalinv
skf7988
Livelong
mikamycin
stafac500
Stafac
V-max

维吉尼霉素生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

[参考文献]

[1]. Parfait R, Cocito C. Lasting damage to bacterial ribosomes by reversibly bound virginiamycin M. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5492-6.

维吉尼霉素物理化学性质

[ 熔点 ]:
170-178ºC

[ 分子式 ]:
C₇₁H₈₄N₁₀O₁₇

[ 分子量 ]:
1349.484

[ 精确质量 ]:
1348.601563

[ PSA ]:
363.76000

[ LogP ]:
4.99230

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
-20℃

维吉尼霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZA4850000

CHEMICAL NAME :: Virginiamycin

CAS REGISTRY NUMBER :: 11006-76-1

LAST UPDATED :: 199707

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,383,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 1,171,1953/1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,383,1978