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蛎灰菌素A

蛎灰菌素A用途

Pristinamycin IIA (RP 12536) 是一种大环内酯类抗生素, 来源于 Streptomyces pristinaespiralis,是 streptogramin A 组抗生素。

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蛎灰菌素A名称

[ CAS 号 ]:
21411-53-0

[ 中文名 ]:
蛎灰菌素A

[ 英文名 ]:
Virginiamycin M1

[中文别名 ]:

维吉尼霉素M1

[英文别名 ]:

Vernamycin A
Staphylomycin M1
STAPHYLOMYCIN
Antibiotic PA-114A1
pristinamycin component IIA
VIRGINIAMYCINE
MIKAMYCIN A
Pristinamycin IIA
VIRGINIAMYCIN M1
Streptogramin A

蛎灰菌素A生物活性

[ 描述 ]:

Pristinamycin IIA (RP 12536) 是一种大环内酯类抗生素, 来源于 Streptomyces pristinaespiralis,是 streptogramin A 组抗生素。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[ 靶点 ]

Bacterial[1]

[参考文献]

[1]. Sezonov G, et al. Complete conversion of antibiotic precursor to pristinamycin IIA by overexpression of Streptomyces pristinaespiralis biosynthetic genes. Nat Biotechnol. 1997 Apr;15(4):349-53.

蛎灰菌素A物理化学性质

[ 密度 ]:
1.26 g/cm3

[ 沸点 ]:
825.2ºC at 760 mmHg

[ 熔点 ]:
165-170 °C

[ 分子式 ]:
C₂₈H₃₅N₃O₇

[ 分子量 ]:
525.59300

[ 闪点 ]:
452.9ºC

[ 精确质量 ]:
525.24800

[ PSA ]:
139.04000

[ LogP ]:
2.92610

[ 外观性状 ]:
淡黄色至棕褐色晶体、粉末或块状

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.586

[ 储存条件 ]:
-20°C

蛎灰菌素A安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3.0

蛎灰菌素A文献

Purification and characterization of virginiamycin M1 reductase from Streptomyces virginiae.

Antimicrob. Agents Chemother. 42 , 2985-2988, (1998)

Virginiamycin M1 (VM1), produced by Streptomyces virginiae, is a polyunsaturated macrocyclic lactone antibiotic belonging to the virginiamycin A group. S. virginiae possesses an activity which stereos...

PapR6, a putative atypical response regulator, functions as a pathway-specific activator of pristinamycin II biosynthesis in Streptomyces pristinaespiralis.

J. Bacteriol. 197(3) , 441-50, (2015)

There are up to seven regulatory genes in the pristinamycin biosynthetic gene cluster of Streptomyces pristinaespiralis, which infers a complicated regulation mechanism for pristinamycin production. I...

VisG is eβential for biosynthesis of virginiamycin S, a streptogramin type B antibiotic, as a provider of the nonproteinogenic amino acid phenylglycine Fitria Ningsih, Shigeru Kitani, et al.

Microbiology 167 , 3213 - 3220, (2011)

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