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胰岛素(人)

胰岛素(人)用途

Insulin(human) 是一种多肽激素,其调节血液中的糖(葡萄糖)水平并且由胰岛的β细胞产生。

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胰岛素(人)名称

[ CAS 号 ]:
11061-68-0

[ 中文名 ]:
人胰岛素

[ 英文名 ]:
Insulin(human)

[中文别名 ]:

[英文别名 ]:

MFCD00131380
Oral-lyn
Penfil R
Ultraphane
EINECS 234-279-7
Umulin
Velosulin HM
ORMD 0801
Insulin(human)

胰岛素(人)生物活性

[ 描述 ]:

Insulin(human) 是一种多肽激素,其调节血液中的糖(葡萄糖)水平并且由胰岛的β细胞产生。

[ 相关类别 ]:

信号通路 >> 蛋白酪氨酸激酶 >> 胰岛素受体

研究领域 >> 代谢疾病

多肽产品

[体外研究]

人胰岛素基因含有两个插入序列,一个位于转录为mRNA的5'-非翻译区段的区域内,另一个中断C-肽编码区[1]。人胰岛素通常用于治疗2型糖尿病[2]。

[参考文献]

[1]. Bell GI, et al. Sequence of the human insulin gene. Nature. 1980 Mar 6;284(5751):26-32.

[2]. Tseng CH, et al. Prolonged use of human insulin increases breast cancer risk in Taiwanese women with type 2 diabetes. BMC Cancer. 2015 Nov 4;15:846.

[相关活性小分子]

胰岛素(人)物理化学性质

[ 分子式 ]:
C₂₅₇H₃₈₃N₆₅O₇₇S₆

[ 分子量 ]:
5807.58

[ 外观性状 ]:
Solution

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
Soluble up to 10mg/ml in pH <3 or in the presence of surfactants. Adjusting pH with a volatile acid (such as formic acid) prior to dry down will allow the product to be re-dissolved in water.

胰岛素(人)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NM8900250

胰岛素(人)文献

Intracellular Ca(2+)-handling differs markedly between intact human muscle fibers and myotubes.

Skelet. Muscle 5 , 26, (2015)

In skeletal muscle, intracellular Ca(2+) is an important regulator of contraction as well as gene expression and metabolic processes. Because of the difficulties to obtain intact human muscle fibers, ...

LipiD-QuanT: a novel method to quantify lipid accumulation in live cells.

J. Lipid Res. 56 , 2206-16, (2015)

Lipid droplets (LDs) are the main storage organelles for triglycerides. Elucidation of lipid accumulation mechanisms and metabolism are essential to understand obesity and associated diseases. Adipoge...

Autophagosome-lysosome fusion is independent of V-ATPase-mediated acidification.

Nat. Commun. 6 , 7007, (2015)

The ATP-dependent proton pump V-ATPase ensures low intralysosomal pH, which is essential for lysosomal hydrolase activity. Based on studies with the V-ATPase inhibitor BafilomycinA1, lysosomal acidifi...

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