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硫酸瑞斯托菌素A

硫酸瑞斯托菌素A用途

Ristomycin sulfate 是可从 Nocardia lurida中分离得到的一种糖肽类抗生素。

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硫酸瑞斯托菌素A名称

[ CAS 号 ]:
11140-99-1

[ 中文名 ]:
瑞斯托菌素硫酸盐

[ 英文名 ]:
Ristomycin sulfate

[中文别名 ]:

瑞斯托霉素硫酸盐

[英文别名 ]:

RISTOCETIN A SULFATE
Ristocetin sulfate salt
RISTOMYCIN MONOSULFATE
RISTOCETINSULFATQ
Ristocetin A sulphate
RISTOCETIN SULFATE
RISTOMYCIN
SPONTIN
ristomycin,sulfate
RISTON

硫酸瑞斯托菌素A生物活性

[ 描述 ]:

Ristomycin sulfate 是可从 Nocardia lurida中分离得到的一种糖肽类抗生素。

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 炎症/免疫

[参考文献]

[1]. M C Berndt, et al. Ristocetin-dependent reconstitution of binding of von Willebrand factor to purified human platelet membrane glycoprotein Ib-IX complex. Biochemistry. 1988 Jan 26;27(2):633-40.

硫酸瑞斯托菌素A物理化学性质

[ 分子式 ]:
C₉₅H₁₁₀N₈O_44.H₂SO₄

[ 分子量 ]:
2165.996

[ 精确质量 ]:
2164.628906

[ PSA ]:
899.20000

[ 外观性状 ]:
白色至灰白色固体

[ 储存条件 ]:
-20°C

硫酸瑞斯托菌素A毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VJ8650000

CHEMICAL NAME :: Ristomycin, sulfate

CAS REGISTRY NUMBER :: 11140-99-1

LAST UPDATED :: 198903

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - excitement Lungs, Thorax, or Respiration - other changes

REFERENCE :: AMBIEH Antibiotiki i Meditsinskaya Biotekhnologiya. Antibiotics and Medical Biotechnology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.30-V.32, 1985-1987 Volume(issue)/page/year: 32,910,1987

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硫酸瑞斯托菌素A安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/38

[ 安全声明 (欧洲) ]:
22-24/25-37/39-26

[ 危险品运输编码 ]:
UN 3249

[ RTECS号 ]:
VJ8650000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

硫酸瑞斯托菌素A文献

Overproduction of Ristomycin A by activation of a silent gene cluster in Amycolatopsis japonicum MG417-CF17.

Antimicrob. Agents Chemother. 58(10) , 6185-96, (2014)

The emergence of antibiotic-resistant pathogenic bacteria within the last decades is one reason for the urgent need for new antibacterial agents. A strategy to discover new anti-infective compounds is...

Jordan, D.C., D. Gottlieb and P. Shaw,, ed.

Antibiotics New York , (1967) 1 , 84

Ristocetin- and thrombin-induced platelet aggregation at physiological shear rates: differential roles for GPIb and GPIIb-IIIa receptor.

Thromb. Haemost. 80 , 428-436, (1998)

We recently reported that washed platelets (WP) activated with ADP and expressing surface-bound vWF aggregated in flow through small tubes or in a cylindrical couette device at physiological shear rat...

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