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芥酸

芥酸用途

Erucic acid 是一种单不饱和脂肪酸 (MUFA),从萝卜的种子中分离出来的。Erucic acid 很容易地穿过血脑屏障 (BBB),它可以使大脑中长链脂肪酸的积累正常化。Erucic acid 可以改善认知障碍并有效预防痴呆。

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芥酸名称

[ CAS 号 ]:
112-86-7

[ 中文名 ]:
芥酸

[ 英文名 ]:
Erucic acid

[中文别名 ]:

[英文别名 ]:

13-Docosenoic acid, (13Z)-
(Z)-13-Docosenoic acid
(Z)-docos-13-enoic acid
Prifac 2990
(13Z)-13-Docosenoic acid
(13Z)-Docosenoic acid
DOCOSENOIC ACID
Prifrac 2990
Erucidic acid
MFCD00063188

芥酸生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> PI3K/Akt/mTOR 信号通路 >> PI3K

研究领域 >> 神经疾病

[体内研究]

与载体处理对照组相比,芥酸(口服3mg/kg)可增强海马中PI3K,PKCζ,ERK,CREB和Akt的磷酸化水平[1]。动物模型：正常幼稚小鼠[1]剂量：3mg/kg给药：口服；3mg/kg结果：增强海马中PI3K,PKCζ,ERK,CREB和Akt的磷酸化水平。

[参考文献]

[1]. Kim E, et al. The memory-enhancing effect of erucic acid on scopolamine-induced cognitive impairment in mice. Pharmacol Biochem Behav. 2016 Mar;142:85-90.

芥酸物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
386.1±0.0 °C at 760 mmHg

[ 熔点 ]:
28-32 °C(lit.)

[ 分子式 ]:
C₂₂H₄₂O₂

[ 分子量 ]:
338.568

[ 闪点 ]:
349.9±15.2 °C

[ 精确质量 ]:
338.318481

[ PSA ]:
37.30000

[ LogP ]:
9.82

[ 外观性状 ]:
白色蜡质固体

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.468

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
水溶性：不溶；易溶于：乙醚,乙醇,甲醇

芥酸MSDS

芥酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
JR1280000

[ 海关编码 ]:
2916190090

芥酸合成路线

芥酸上下游产品

芥酸上游产品

芥酸下游产品

芥酸制备

1.以菜油或油脚为原料，用传统的方法（皂化酸解；酸化水解或加压水解）水解制成菜油脂肪酸，再从菜油脂肪酸分离出芥酸。对混合脂肪酸采用冷冻；压榨；初步分离后，再采用减压精馏可得较纯的芥酸。

2.由芥菜的籽实经发酵和蒸馏精制得芥子油和芥酸,再经分离提纯而得。

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芥酸海关

[ 海关编码 ]: 2916190090

[ 中文概述 ]:
2916190090 其他不饱和无环一元羧酸（包括其酸酐、酰卤化物，过氧化物和过氧酸以及它们的衍生物）。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

芥酸文献

Genotoxicity testing of esterified propoxylated glycerol (EPG).

Regul Toxicol Pharmacol 70 Suppl 2 , S131-42, (2014)

Four versions of esterified propoxylated glycerols (EPGs) were evaluated for potential genotoxicity using a range of in vitro and in vivo assays. H-EPG-05 HR/SO 9:1, H-EPG-05 soyate, and H-EPG-14 soya...

Development and application of a comparative fatty acid analysis method to investigate voriconazole-induced hepatotoxicity.

Clin. Chim. Acta 438 , 126-34, (2014)

As fatty acids play an important role in biological regulation, the profiling of fatty acid expression has been used to discover various disease markers and to understand disease mechanisms. This stud...

An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.

J. Nat. Prod. 73 , 1193-5, (2010)

Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple fo...

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芥酸