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L-4-氟苯丙氨酸

L-4-氟苯丙氨酸用途

对氟-L-苯丙氨酸(4-氟-L-苯丙氨酸)是酪氨酸羟化酶(TH)的底物,可用于研究该酶的调节。对氟-L-苯丙氨酸与大肠杆菌的L-亮氨酸特异性受体结合(KD=0.26μM)[1][2]。

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L-4-氟苯丙氨酸名称

[ CAS 号 ]:
1132-68-9

[ 中文名 ]:
L-4-氟苯丙氨酸

[ 英文名 ]:
4-Fluoro-Phe-OH

[中文别名 ]:

[英文别名 ]:

L-4-FLUOROPHE
(2R)-2-Amino-3-(4-fluorophenyl)propanoic acid
D,L-p-fluorophenylalanine
L-4-F-Phe-OH
L-p-fluorophenylalanine
4-Fluorophenylalanine
H-Phe(4-F)-OH
H-L-PHE(4-F)-OH
L-4-Fluorophenylalanine
4-fluoroPhe

L-4-氟苯丙氨酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Luck LA, et al. Fluorescence and 19F NMR evidence that phenylalanine, 3-L-fluorophenylalanine and 4-L-fluorophenylalanine bind to the L-leucine specific receptor of Escherichia coli. Protein Sci. 2000;9(12):2573-2576.

[2]. Hillas PJ, et al. A mechanism for hydroxylation by tyrosine hydroxylase based on partitioning of substituted phenylalanines. Biochemistry. 1996;35(22):6969-6975.

[3]. Luck LA, et al. Fluorescence and 19F NMR evidence that phenylalanine, 3-L-fluorophenylalanine and 4-L-fluorophenylalanine bind to the L-leucine specific receptor of Escherichia coli. Protein Sci. 2000;9(12):2573-2576.

L-4-氟苯丙氨酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
313.3±32.0 °C at 760 mmHg

[ 熔点 ]:
~255 °C (dec.)

[ 分子式 ]:
C₉H₁₀FNO₂

[ 分子量 ]:
183.180

[ 闪点 ]:
143.3±25.1 °C

[ 精确质量 ]:
183.069550

[ PSA ]:
63.32000

[ LogP ]:
1.16

[ 外观性状 ]:
白色至灰白色粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.555

[ 储存条件 ]:
室温，密封，干燥

L-4-氟苯丙氨酸MSDS

L-4-氟苯丙氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S23-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DW1765000

L-4-氟苯丙氨酸合成路线

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L-4-氟苯丙氨酸文献

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...

Regulation of rat liver phenylalanine hydroxylase. I. Kinetic properties of the enzyme's iron and enzyme reduction site.

J. Biol. Chem. 269 , 24637, (1994)

Tetrahydropterins react with phenylalanine hydroxylase at a redox site, a regulatory site, and the catalytic site, but neither the properties of nor relationships among these sites are well understood...

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