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H-8 二氢氯化物

H-8 二氢氯化物用途

H-8(盐酸)是一种细胞渗透性、可逆性和ATP竞争性PKA抑制剂[1]。

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H-8 二氢氯化物名称

[ CAS 号 ]:
113276-94-1

[ 中文名 ]:
H-8 二氢氯化物

[ 英文名 ]:
h-8 dihydrochloride

[中文别名 ]:

[英文别名 ]:

H-8 dihydrochloride
MFCD00036962

H-8 二氢氯化物生物活性

[ 描述 ]:

H-8(盐酸)是一种细胞渗透性、可逆性和ATP竞争性PKA抑制剂[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白酪氨酸激酶 >> PKA

信号通路 >> 干细胞及 Wnt 通路 >> PKA

[参考文献]

[1]. Niisato N, et al. Effects of PKA inhibitors, H-compounds, on epithelial Na+ channels via PKA-independent mechanisms. Life Sci. 1999;65(10):PL109-14.

H-8 二氢氯化物物理化学性质

[ 沸点 ]:
473.9ºC at 760 mmHg

[ 熔点 ]:
221-222℃ (methanol water )

[ 分子式 ]:
C₁₂H₁₇Cl₂N₃O₂S

[ 分子量 ]:
338.25300

[ 闪点 ]:
240.4ºC

[ 精确质量 ]:
337.04200

[ PSA ]:
79.47000

[ LogP ]:
4.19910

[ 外观性状 ]:
白色至灰白色结晶固体

[ 蒸汽压 ]:
3.79E-09mmHg at 25°C

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
ethanol: 25 mg/mL, clear, colorless

H-8 二氢氯化物MSDS

H-8 二氢氯化物安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2935009090

H-8 二氢氯化物合成路线

H-8 二氢氯化物上下游产品

H-8 二氢氯化物上游产品

H-8 二氢氯化物下游产品

H-8 二氢氯化物海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

H-8 二氢氯化物文献

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.

Biochemistry 23 , 5036-5041, (1984)

Naphthalenesulfonamides such as N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) are potent calmodulin (CaM) antagonists and act upon several protein kinases at higher concentration. When the...

In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C.

Mol. Cell. Biol. 9 , 2424, (1989)

We have examined whether a precursor form of NF-kappa B, a DNA-binding protein that plays a role in the transcriptional control of several genes, including kappa immunoglobulin light chain and interle...

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