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N-苄氧羰基甘氨酸

N-苄氧羰基甘氨酸用途

Z-甘氨酸是甘氨酸(HY-Y0966)衍生物[1]。

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N-苄氧羰基甘氨酸名称

[ CAS 号 ]:
1138-80-3

[ 中文名 ]:
N-苄氧羰基甘氨酸

[ 英文名 ]:
Z-Gly-OH

[中文别名 ]:

[英文别名 ]:

Cbz-Gly-OH
CBZ-GLYCINE
QV1MVO1R
N-[(Benzyloxy)carbonyl]glycine
N-Carbobenzoxyglycine
Z-GLY-OH
CBZ-GLY
N-Carbobenzyloxyglycine
Z-GLYCINE
Glycine, N-[(phenylmethoxy)carbonyl]-

N-苄氧羰基甘氨酸生物活性

[ 描述 ]:

Z-甘氨酸是甘氨酸(HY-Y0966)衍生物[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

氨基酸和氨基酸衍生物已被商业化用作能量补充剂。它们影响合成代谢激素的分泌、运动期间的燃料供应、压力相关任务期间的精神表现,并防止运动引起的肌肉损伤。它们被认为是有益的能生膳食物质[1]。

[参考文献]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

N-苄氧羰基甘氨酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
424.0±38.0 °C at 760 mmHg

[ 熔点 ]:
118-122 °C(lit.)

[ 分子式 ]:
C₁₀H₁₁NO₄

[ 分子量 ]:
209.199

[ 闪点 ]:
210.2±26.8 °C

[ 精确质量 ]:
209.068802

[ PSA ]:
75.63000

[ LogP ]:
1.37

[ 外观性状 ]:
略米色粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.554

[ 储存条件 ]:
库房低温通风干燥

[ 水溶解性 ]:
methanol: 0.1 g/mL, clear

N-苄氧羰基甘氨酸MSDS

N-苄氧羰基甘氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MB9129000

CHEMICAL NAME :: Glycine, N-carboxy-, N-benzyl ester

CAS REGISTRY NUMBER :: 1138-80-3

BEILSTEIN REFERENCE NO. :: 0526877

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H11-N-O4

MOLECULAR WEIGHT :: 209.22

WISWESSER LINE NOTATION :: QVN1R&1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravaginal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 280 mg/kg

SEX/DURATION :: female 28 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 70,60,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

DOSE :: 280 mg/kg

SEX/DURATION :: female 28 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 70,60,1981

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N-苄氧羰基甘氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R62

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
MB9129000

[ 海关编码 ]:
2924299090

N-苄氧羰基甘氨酸合成路线

N-苄氧羰基甘氨酸上下游产品

N-苄氧羰基甘氨酸上游产品

N-苄氧羰基甘氨酸下游产品

N-苄氧羰基甘氨酸制备

在冷却下，将氯甲酸苄酯和氢氧化钠溶液滴加到甘氨酸和氢氧化钠溶液的混合物中，同时激烈搅拌。反应毕，静置分出油层。水层用乙醚提取后冷却酸化至刚果红酸性，滤了沉淀，水洗、干燥，得产品苄氧羰基甘氨酸。产率86-91%

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N-苄氧羰基甘氨酸海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N-苄氧羰基甘氨酸文献

Anticonvulsant activities of N-benzyloxycarbonylglycine after parenteral administration.

Neuroreport 5(7) , 777-80, (1994)

Although glycine does not cross easily the blood-brain barrier, it exhibits at very high doses (10-40 mmol kg-1) a modest anticonvulsant activity. In this study, carbamate derivatives--N-benzyloxycarb...

Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM).

Bioorg. Med. Chem. 16 , 10061-74, (2008)

Peptidyl alpha-hydroxylating monooxygenase (PHM) functions in vivo towards the biosynthesis of alpha-amidated peptide hormones in mammals and insects. PHM is a potential target for the development of ...

Synthesis and anticonvulsant activity of N-benzyloxycarbonyl-amino acid prodrugs of phenytoin.

J. Pharm. Pharmacol. 51 , 549-553, (1999)

Glycine, which has weak anticonvulsant properties, has been shown to potentiate the activity of several antiepileptic drugs but not phenytoin. Recently, studies have shown that N-(benzyloxycarbonyl)gl...

更多文献

N-苄氧羰基甘氨酸

N-苄氧羰基甘氨酸用途

N-苄氧羰基甘氨酸名称

N-苄氧羰基甘氨酸生物活性

N-苄氧羰基甘氨酸物理化学性质

N-苄氧羰基甘氨酸MSDS

详细MSDS(安全技术说明书)

N-苄氧羰基甘氨酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

N-苄氧羰基甘氨酸安全信息

N-苄氧羰基甘氨酸合成路线

详细合成路线

N-苄氧羰基甘氨酸上下游产品

N-苄氧羰基甘氨酸上游产品

N-苄氧羰基甘氨酸下游产品

N-苄氧羰基甘氨酸制备

N-苄氧羰基甘氨酸海关

N-苄氧羰基甘氨酸文献

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