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没食子酸十二酯

没食子酸十二酯用途

Dodecyl gallate (Lauryl gallate) 广泛用作食品制造及制药和化妆品行业中的抗氧化剂。Dodecyl gallate 还对动物病毒,如非洲猪瘟病毒 (ASFV)具有作用活性。

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没食子酸十二酯名称

[ CAS 号 ]:
1166-52-5

[ 中文名 ]:
没食子酸月桂酯

[ 英文名 ]:
Dodecyl gallate

[中文别名 ]:

[英文别名 ]:

3,4,5-trihydroxy-benzoic acid dodecyl ester
Nipagallin LA
3mg/kg
dodecyl3,4,5
Benzoic acid, 3,4,5-trihydroxy-, dodecyl ester
Dodecyl gallate
E312
MFCD00002195
Lauryl gallate
Gallic acid, lauryl ester

没食子酸十二酯生物活性

[ 描述 ]:

Dodecyl gallate (Lauryl gallate) 广泛用作食品制造及制药和化妆品行业中的抗氧化剂。Dodecyl gallate 还对动物病毒,如非洲猪瘟病毒 (ASFV)具有作用活性。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[体外研究]

没食子酸十二烷基酯是没食子酸的酯衍生物,没食子酸是一种天然植物酚类化合物。没食子酸十二烷基酯(月桂基没食子酸酯)在清除自由基、抑制脂质过氧化相关酶和增加抗氧化基因表达的过程中保护细胞免受氧化应激。由于其疏水性,没食子酸十二酯可以破坏生物膜并导致蛋白质失活[1]。

[参考文献]

[1]. Patricia de León, et al. Inhibition of Porcine Viruses by Different Cell-Targeted Antiviral Drugs. Front Microbiol. 2019 Aug 14;10:1853.

没食子酸十二酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
521.7±45.0 °C at 760 mmHg

[ 熔点 ]:
94-97 °C(lit.)

[ 分子式 ]:
C₁₉H₃₀O₅

[ 分子量 ]:
338.439

[ 闪点 ]:
180.3±22.2 °C

[ 精确质量 ]:
338.209320

[ PSA ]:
86.99000

[ LogP ]:
7.38

[ 外观性状 ]:
白色粒状

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.535

[ 储存条件 ]:
0-6°C

[ 水溶解性 ]:
practically insoluble

没食子酸十二酯MSDS

没食子酸十二酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH9100000

CHEMICAL NAME :: Benzoic acid, 3,4,5-trihydroxy-, dodecyl ester

CAS REGISTRY NUMBER :: 1166-52-5

BEILSTEIN REFERENCE NO. :: 2701981

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H30-O5

MOLECULAR WEIGHT :: 338.49

WISWESSER LINE NOTATION :: QR BQ CQ EVO12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 38A,22,1965 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 135 gm/kg/32W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JAOCA7 Journal of the American Oil Chemists' Society. (Champaign, IL) V.24-56, 1947-79. Volume(issue)/page/year: 28,304,1951

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 gm/kg/10D-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Related to Chronic Data - death

REFERENCE :: JAOCA7 Journal of the American Oil Chemists' Society. (Champaign, IL) V.24-56, 1947-79. Volume(issue)/page/year: 28,304,1951

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没食子酸十二酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R43

[ 安全声明 (欧洲) ]:
S24-S37

[ 危险品运输编码 ]:
3335

[ WGK德国 ]:
1

[ RTECS号 ]:
DH9100000

[ 海关编码 ]:
29182950

没食子酸十二酯合成路线

没食子酸十二酯上下游产品

没食子酸十二酯上游产品

没食子酸十二酯下游产品

没食子酸十二酯制备

由没食子酸和月桂醇酯化而得。

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没食子酸十二酯海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

没食子酸十二酯文献

Apolar Radical Initiated Conjugated Autoxidizable Triene (ApoCAT) Assay: Effects of Oxidant Locations on Antioxidant Capacities and Interactions.

J. Agric. Food Chem. 63 , 7546-55, (2015)

Development of an antioxidant assay explaining antioxidant behaviors in complex food systems has been a challenging topic for food scientists. This research aimed to investigate antioxidant capacities...

Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.

Bioorg. Med. Chem. Lett. 19 , 1793-6, (2009)

The antifungal activity of a complete series of 15 n-alkyl gallates and six analogues acting against a representative panel of opportunistic pathogenic fungi was studied in order to analyze their role...

The sensitizing capacity of the antioxidants propyl, octyl, and dodecyl gallate and some related gallic acid esters.

Contact Dermatitis 26(4) , 253-8, (1992)

8 alkyl gallates, including the widely used antioxidants propyl, octyl, and dodecyl (= lauryl) gallate, have been subjected to experimental sensitization in guinea pigs. Using a modern sensitization p...

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没食子酸十二酯

没食子酸十二酯用途

没食子酸十二酯名称

没食子酸十二酯生物活性

没食子酸十二酯物理化学性质

没食子酸十二酯MSDS

详细MSDS(安全技术说明书)

没食子酸十二酯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

没食子酸十二酯安全信息

没食子酸十二酯合成路线

详细合成路线

没食子酸十二酯上下游产品

没食子酸十二酯上游产品

没食子酸十二酯下游产品

没食子酸十二酯制备

没食子酸十二酯海关

没食子酸十二酯文献

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