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没食子酸; 3,4,5-三羟基苯甲酸

没食子酸; 3,4,5-三羟基苯甲酸用途

Gallic acid 是 COX-2 的抑制剂。

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没食子酸; 3,4,5-三羟基苯甲酸名称

[ CAS 号 ]:
149-91-7

[ 中文名 ]:
没食子酸

[ 英文名 ]:
Gallic acid

[中文别名 ]:

[英文别名 ]:

3,4,5-trihydroxybenzenoic Acid
Gallic acid
Benzoic acid, 3,4,5-trihydroxy-
graphite oxide
kyselinagallova
3,4,5-Trihydroxy-benzoic acid
Acid, Gallic
BETZ 0276
3,4,5-Trihydroxybenzoic acid
gallic

没食子酸; 3,4,5-三羟基苯甲酸生物活性

[ 描述 ]:

Gallic acid 是 COX-2 的抑制剂。

[ 相关类别 ]:

研究领域 >> 代谢疾病

研究领域 >> 癌症

天然产物 >> 酚类

[ 靶点 ]

COX-2

[体外研究]

没食子酸是一种能够抑制COX-2的抗氧化剂[1]。用没食子酸处理18小时后,活的中性粒细胞的数量从40.3％急剧下降到27.7％,与未处理的中性粒细胞的26.4％高度相当。没食子酸不能减弱异丙肾上腺素诱导的肌细胞溶解[3]。

[体内研究]

食品摄入量(2.6±0.08克/天,p = 0.69)和没食子酸组的体重(2.5±0.69 g,p = 0.76)与对照组没有显着差异(食物摄入量; 2.41± 0.14克/天,体重; 2.83±0.84克/天)。治疗2周后,没食子酸组的血糖耐受性显着提高。在2周的治疗期后,没食子酸组的血糖耐受性在90和120分钟时也显着优于对照组(p <0.05)。相对于对照组(1.08±0.20mM),没食子酸组中的血清甘油三酯浓度(0.67±0.03mM,p <0.05)显着降低。对照组(3.19±0.27 mM)和没食子酸组(3.01±0.18 mM)的总胆固醇浓度相似[2]。

[细胞实验]

用RPMI1640 / 10％FBS中的8μg/ mL没食子酸处理嗜中性粒细胞3小时，6小时，9小时和18小时。在没食子酸处理结束时，根据制造商的说明用Annexin V-FITC和PI染色细胞。简而言之，用冰冷的PBS洗涤细胞两次，并以1×10 6个细胞/ mL的浓度重悬于1×结合缓冲液中。将细胞悬浮液（100μL中的1×10 5个细胞）与5μL膜联蛋白V-FITC和10μLPI在5mL培养管中在室温下孵育20分钟。在流式细胞仪系统上立即分析染色的细胞[3]。

[动物实验]

在该研究中使用5周龄雄性C57BL / 6小鼠。将动物保持在22℃的温控室中，12小时光暗光照。将小鼠分成对照载体组和没食子酸组。持续2周，每天用载体（10％酒精，10％吐温80和80％盐水）单独或用10mg / kg没食子酸给小鼠施用腹膜内治疗。在该处理之后，再次进行GTT，并取血样用于随后的生化分析。在实验期间，每天测量食物摄入量和体重[2]。

[参考文献]

[1]. Amaravani M, et al. COX-2 structural analysis and docking studies with gallic acid structural analogues. Springerplus. 2012 Dec;1(1):58.

[2]. Bak EJ, et al. Gallic acid improves glucose tolerance and triglyceride concentration in diet-induced obesity mice. Scand J Clin Lab Invest. 2013 Dec;73(8):607-14.

[3]. Cheng Y, et al. Plant Natural Products Calycosin and Gallic Acid Synergistically Attenuate Neutrophil Infiltration and Subsequent Injury in Isoproterenol-Induced Myocardial Infarction: A Possible Role for Leukotriene B4 12-Hydroxydehydrogenase? Oxid Med Cell Longev. 2015;2015:434052.

[相关活性小分子]

没食子酸; 3,4,5-三羟基苯甲酸物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
501.1±50.0 °C at 760 mmHg

[ 熔点 ]:
252 °C (dec.)(lit.)

[ 分子式 ]:
C₇H₆O₅

[ 分子量 ]:
170.120

[ 闪点 ]:
271.0±26.6 °C

[ 精确质量 ]:
170.021530

[ PSA ]:
97.99000

[ LogP ]:
0.91

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.730

[ 储存条件 ]:
库房低温,通风,干燥

[ 稳定性 ]:
Stability Stable, but may discolour upon exposure to light. Hygroscopic. Incompatible with strong oxidizing agents, strong bases, acid chlorides, acid anhydrides.

[ 水溶解性 ]:
12 g/L cold water

没食子酸; 3,4,5-三羟基苯甲酸MSDS

详细MSDS(安全技术说明书)

没食子酸; 3,4,5-三羟基苯甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LW7525000

CHEMICAL NAME :: Gallic acid

CAS REGISTRY NUMBER :: 149-91-7

BEILSTEIN REFERENCE NO. :: 2050274

LAST UPDATED :: 199701

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C7-H6-O5

MOLECULAR WEIGHT :: 170.13

WISWESSER LINE NOTATION :: QVR CQ DQ EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - other changes Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 5 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 50 mg/L

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 14,251,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84280 No. of Facilities: 549 (estimated) No. of Industries: 21 No. of Occupations: 10 No. of Employees: 2520 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84280 No. of Facilities: 294 (estimated) No. of Industries: 14 No. of Occupations: 8 No. of Employees: 2184 (estimated) No. of Female Employees: 252 (estimated)

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没食子酸; 3,4,5-三羟基苯甲酸安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
LW7525000

[ 海关编码 ]:
2918290000

没食子酸; 3,4,5-三羟基苯甲酸合成路线

详细合成路线

没食子酸; 3,4,5-三羟基苯甲酸上下游产品

没食子酸; 3,4,5-三羟基苯甲酸上游产品

没食子酸; 3,4,5-三羟基苯甲酸下游产品

没食子酸; 3,4,5-三羟基苯甲酸制备

由五倍子制得。五倍子的主要成分为单宁酸，属水解类单宁，能溶于热水，具有涩味，是和种无定形的复杂有机物。我国五倍子单宁酸是由五倍子酸、双倍酸与葡萄糖结合以甙或酯的形式形成的复杂混合物。单宁酸经加压水解即生成没食子酸和葡萄糖。水解时先生成以没食子酸酯，再由双没食子酸酯水解成没食子酸，水解温度为133-135℃，压力为0.18-0.2MPa。从升压至0.18MPa开始反应保持2h即达终点。与常压水解比较，可节约硫酸和蒸汽，生产能力可提高25%。

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没食子酸; 3,4,5-三羟基苯甲酸海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

没食子酸; 3,4,5-三羟基苯甲酸文献

Urinary metabolic fingerprinting of mice with diet-induced metabolic derangements by parallel dual secondary column-dual detection two-dimensional comprehensive gas chromatography.

J. Chromatogr. A. 1361 , 265-76, (2014)

This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse u...

Vegetables' juice influences polyol pathway by multiple mechanisms in favour of reducing development of oxidative stress and resultant diabetic complications.

Pharmacogn. Mag. 10(Suppl 2) , S383-91, (2014)

Hyperglycemia induced generation of free radicals and consequent development of oxidative stress by polyol pathway is one of the crucial mechanisms stirring up development of diabetic complications. W...

Antimicrobial activity of natural products from the flora of Northern Ontario, Canada.

Pharm. Biol. 53(6) , 800-6, (2015)

The number of multidrug resistant (MDR) microorganisms is increasing and the antimicrobial resistance expressed by these pathogens is generating a rising global health crisis. In fact, there are only ...

更多文献

没食子酸; 3,4,5-三羟基苯甲酸

没食子酸; 3,4,5-三羟基苯甲酸用途

没食子酸; 3,4,5-三羟基苯甲酸名称

没食子酸; 3,4,5-三羟基苯甲酸生物活性

没食子酸; 3,4,5-三羟基苯甲酸物理化学性质

没食子酸; 3,4,5-三羟基苯甲酸MSDS

详细MSDS(安全技术说明书)

没食子酸; 3,4,5-三羟基苯甲酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

没食子酸; 3,4,5-三羟基苯甲酸安全信息

没食子酸; 3,4,5-三羟基苯甲酸合成路线

详细合成路线

没食子酸; 3,4,5-三羟基苯甲酸上下游产品

没食子酸; 3,4,5-三羟基苯甲酸上游产品

没食子酸; 3,4,5-三羟基苯甲酸下游产品

没食子酸; 3,4,5-三羟基苯甲酸制备

没食子酸; 3,4,5-三羟基苯甲酸海关

没食子酸; 3,4,5-三羟基苯甲酸文献

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