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6-(2-(2-氯苯基-4-羟苯基)-1,3-二烷-5-基)己烯酸

用途

ICI 192605是一种有效的TXA2R(血栓素A2受体)拮抗剂,作为细胞信号前列腺素。ICI 192605阻断U-46619诱导的离体豚鼠气管收缩[1]。

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名称

[ CAS 号 ]:
117621-64-4

[ 中文名 ]:
6-(2-(2-氯苯基-4-羟苯基)-1,3-二烷-5-基)己烯酸

[ 英文名 ]:
ICI 192605

[英文别名 ]:

(4Z)-rel

生物活性

[ 描述 ]:

ICI 192605是一种有效的TXA2R(血栓素A2受体)拮抗剂,作为细胞信号前列腺素。ICI 192605阻断U-46619诱导的离体豚鼠气管收缩[1]。

[ 相关类别 ]:

研究领域 >> 内分泌

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体

[参考文献]

[1]. Brewster AG, et al. The synthesis of a novel thromboxane receptor antagonist 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl) hexenoic acid ICI 192605. Prostaglandins. 1988 Aug;36(2):173-8.

物理化学性质

[ 密度 ]:
1.262 g/cm3

[ 沸点 ]:
540.1ºC at 760 mmHg

[ 分子式 ]:
C₂₂H₂₃ClO₅

[ 分子量 ]:
402.86800

[ 闪点 ]:
280.4ºC

[ 精确质量 ]:
402.12300

[ PSA ]:
75.99000

[ LogP ]:
5.25960

[ 蒸汽压 ]:
1.7E-12mmHg at 25°C

[ 折射率 ]:
1.583

安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H410

[ 警示性声明 ]:
P273-P501

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

文献

Thromboxane and isoprostane share the same prostanoid receptors to increase human placental tone

Placenta 32(12) , 941-8, (2011)

As the placenta is devoid of autonomic innervation, umbilical-placental vascular tone should be under the control of tissue and humoral factors. Among the numerous stimuli capable of challenging the p...

Role of Ca2+ mobilization and Ca2+ sensitization in 8-iso-PGF 2 alpha-induced contraction in airway smooth muscle.

Clin. Exp. Allergy 39(2) , 236-45, (2009)

Isoprostanes are prostaglandin (PG)-like compounds synthesized by oxidative stress, not by cyclooxygenase, and increase in bronchoalveolar lavage fluid of patients with asthma. The airway inflammation...

Endothelial thromboxane production plays a role in the contraction caused by 5-hydroxytryptamine in rat basilar arteries.

Eur. J. Pharmacol. 243(2) , 193-9, (1993)

The goal of the present study was to characterize the role of the endothelium in the 5-hydroxytryptamine (5-HT)-induced contraction of the rat basilar artery. Rat basilar artery segments were mounted ...

更多文献

6-(2-(2-氯苯基-4-羟苯基)-1,3-二烷-5-基)己烯酸

用途

名称

生物活性

物理化学性质

安全信息

文献

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