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麦芽酚

麦芽酚用途

Maltol,芳香化合物的类型,在红参中高浓度存在。Maltol 是一种有效的抗氧化剂,用于增强味道和保藏食品。

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麦芽酚名称

[ CAS 号 ]:
118-71-8

[ 中文名 ]:
2-甲基-3-羟基-4-吡喃酮

[ 英文名 ]:
Maltol

[中文别名 ]:

[英文别名 ]:

3-Hydroxy-2-methyl-4H-pyran-4-one
MALTENE
3-hydroxy-2-methyl-4-pyrone
3-Hydroxy-2-methyl-g-pyrone
Vetol
Palatone
Laricin
4H-Pyran-4-one, 3-hydroxy-2-methyl-
Talmon
3-Hydroxy-2-methyl-4-pyrone,Maltol

麦芽酚生物活性

[ 描述 ]:

Maltol,芳香化合物的类型,在红参中高浓度存在。Maltol 是一种有效的抗氧化剂,用于增强味道和保藏食品。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Guo N, et al. Maltol, a food flavor enhancer, attenuates diabetic peripheral neuropathy in streptozotocin-induceddiabetic rats. Food Funct. 2018 Dec 13;9(12):6287-6297.

麦芽酚物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
284.7±40.0 °C at 760 mmHg

[ 熔点 ]:
160-164 °C(lit.)

[ 分子式 ]:
C₆H₆O₃

[ 分子量 ]:
126.110

[ 闪点 ]:
127.3±20.8 °C

[ 精确质量 ]:
126.031693

[ PSA ]:
50.44000

[ LogP ]:
0.08

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.561

[ 储存条件 ]:
室温

[ 水溶解性 ]:
1.2 g/100 mL (25 ºC)

麦芽酚MSDS

麦芽酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ1050000

CHEMICAL NAME :: 4H-Pyran-4-one, 3-hydroxy-2-methyl-

CAS REGISTRY NUMBER :: 118-71-8

BEILSTEIN REFERENCE NO. :: 0112169

LAST UPDATED :: 199712

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C6-H6-O3

MOLECULAR WEIGHT :: 126.12

WISWESSER LINE NOTATION :: T6O DVJ B1 CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1410 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 550 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD16 - Lethal Dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 820 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1620 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1410 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 3720 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 90 gm/kg/90D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 20500 mg/kg/41D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,487,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2610 No. of Facilities: 508 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 1733 (estimated) No. of Female Employees: 642 (estimated)

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麦芽酚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S37-S37/39-S26-S36-S36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UQ1050000

[ 海关编码 ]:
2932999099

麦芽酚合成路线

麦芽酚上下游产品

麦芽酚上游产品

麦芽酚下游产品

麦芽酚制备

1.麦芽醇有三种主要制法：1.从天然产物中提取麦芽醇存在于小麦、大豆的分解液中和大麦焙烧凝缩物中，也存在于某些枞树和落叶松树皮层中。1986年美国就用萃取结晶法从木醋中提取麦芽醇。1970年美国又从落叶松树皮中用氯仿提取麦芽醇。日本从连香树叶中用氯仿直接浸提或从其水蒸气蒸馏液中提取。从木材干馏所得的木焦油进行减压蒸馏也可分离到麦芽醇。2.半合成法（以曲酸为原料）曲酸的母体是葡萄糖，相当于3-酮-葡萄糖的脱水产物。将淀粉用黄曲霉菌发酵，在发酵液中产生的曲酸，经转变成曲酸把催化下用空气（或氧气）氧化成靠闷酸，然后在225℃下脱羧成焦袂康酸。在碱性条件下将焦袂康酸与甲醛反应，生成羟基麦芽醇。然后用盐酸和锌粉进行还原得麦芽醇。经蒸馏或升华，在氯仿中重结晶，即得麦芽醇成品。从曲酸制成靠闷酸，也可通过曲酸与氯化苄经醚化生成曲酸苄醚，再用二氧化锰氧化成靠闷酸醚，然后脱苄基生成靠闷酸。3.用糖醛为原料合成麦芽醇。

2.糠醇法
糠醇在甲醇水溶液中通人氯气氯化生成4-氯代-6-羟基-2[H]-吡喃-3[6H]-酮，然后加热水解得焦袂康酸，在碱性下将其与甲醛缩合得羟甲基焦袂康酸，用锌粉在盐酸中将其还原为麦芽酚。半合成法
以淀粉为原料，经梨头霉发酵制得曲酸。曲酸与氯化苄在氢氧化钠-甲醇溶液中醚化生成曲酸苄醚；然后用二氧化锰氧化生成考门酸苄醚，并在盐酸存在下脱苄生成考门酸，再脱羧成为焦袂康酸，最后与甲醛化合，并用锌粉还原成麦芽酚。
糠醛法
糠醛与甲基溴化镁作用得到甲基糠醇，然后在甲醇水溶液中、0℃下通氯气氧化，接着加热至100℃水解得到麦芽酚。此法原料来源广，工艺路线短，条件温和，设备简单，“三废”少，有较好的发展前景。

由发酵法制得曲酸后与氯化苄进行醚化得曲酸苄醚，经二氧化锰和盐酸催化下生成考闷酸，再经脱羧得焦炔康酸，经甲基化而成。
用氮杂环己烷反应成焦炔康酸，然后在2位甲基化后制成。
乙二酸二乙酯在乙醇钠存在下与丙酮缩合后在三氯甲烷溶液中通入溴，得γ-衍生物；再由氢氧化钾进行加水分解成袂康酸，然后加热脱羧基得焦袂康酸，用甲醛和哌啶处理再还原而得。

3.将曲酸在钯催化下用空气（或氧气）氧化成靠闷酸，再高温脱羧成焦羨康酸。在碱性条件下与甲醛反应，生成羟基麦芽醇。然后用盐酸和锌粉进行还原得麦芽醇。经蒸馏或升华，在氯仿中重结晶，即得麦芽醇精品。

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麦芽酚海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

麦芽酚文献

Interaction of vanadium(IV) with human serum apo-transferrin.

J. Inorg. Biochem. 121 , 187-95, (2013)

The interaction of V(IV)O-salts as well as of a few V(IV)O(carrier)n complexes with human serum transferrin (hTF) is studied focusing on the determination of the nature and stoichiometry of the bindin...

Identifying chelators for metalloprotein inhibitors using a fragment-based approach.

J. Med. Chem. 54 , 591-602, (2011)

Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced...

Approaches of aroma extraction dilution analysis (AEDA) for headspace solid phase microextraction and gas chromatography-olfactometry (HS-SPME-GC-O): Altering sample amount, diluting the sample or adjusting split ratio?

Food Chem. 187 , 44-52, (2015)

Aroma extract dilution analysis (AEDA) is widely used for the screening of aroma-active compounds in gas chromatography-olfactometry (GC-O). In this study, three aroma dilution methods, (I) using diff...

更多文献

麦芽酚

麦芽酚用途

麦芽酚名称

麦芽酚生物活性

麦芽酚物理化学性质

麦芽酚MSDS

详细MSDS(安全技术说明书)

麦芽酚毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

麦芽酚安全信息

麦芽酚合成路线

详细合成路线

麦芽酚上下游产品

麦芽酚上游产品

麦芽酚下游产品

麦芽酚制备

麦芽酚海关

麦芽酚文献

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