三溴苯酚

三溴苯酚用途

【用途一】
用于制取消毒防腐药三溴酚铋等。三溴酚可用溶液缩聚法或水相沉淀缩聚法制成聚2,6-二溴苯醚。这是一种新开发的阻燃剂，可用于尼龙66、热塑性聚酯以及改性聚苯醚等工程塑料，也可用于高抗冲聚苯乙烯、ABS树脂。
【用途二】
用于制取消毒防腐药三溴酚铋等。三溴酚可用溶液缩聚法或水相沉淀缩聚法制成聚2,6-二溴苯醚。这是一种新开发的阻燃剂，可用于尼龙66、热塑性聚酯以及改性聚苯醚等工程塑料，也可用于高抗冲聚苯乙烯、ABS树脂

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三溴苯酚名称

[ CAS 号 ]:
118-79-6

[ 中文名 ]:
三溴苯酚

[ 英文名 ]:
2,4,6-Tribromophenol

[中文别名 ]:

[英文别名 ]:

BROMOL
EINECS 204-278-6
2,4,6-Tribromophenol
TA 10
HOC6H2Br3-2.4.6
2,4,6-tribromo-phenol
Tribromophenol
MFCD00002150
Flammex 3BP
Bromkal pur 3

三溴苯酚物理化学性质

[ 密度 ]:
2.4±0.1 g/cm3

[ 沸点 ]:
286.8±0.0 °C at 760 mmHg

[ 熔点 ]:
90-94 °C(lit.)

[ 分子式 ]:
C₆H₃Br₃O

[ 分子量 ]:
330.799

[ 闪点 ]:
109.7±25.9 °C

[ 精确质量 ]:
327.773376

[ PSA ]:
20.23000

[ LogP ]:
4.33

[ 外观性状 ]:
软白色晶体

[ 蒸汽密度 ]:
11.4 (vs air)

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.674

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
71 mg/L (15 ºC)

三溴苯酚MSDS

详细MSDS(安全技术说明书)

三溴苯酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SN1225000

CHEMICAL NAME :: Phenol, 2,4,6-tribromo-

CAS REGISTRY NUMBER :: 118-79-6

LAST UPDATED :: 199806

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C6-H3-Br3-O

MOLECULAR WEIGHT :: 330.82

WISWESSER LINE NOTATION :: QR BE DE FE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0523296 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,524,1986

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1630 mg/m3/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - ptosis

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0523305

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0522208 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 920 mg/m3/6H/3W-I

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of salivary glands Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536719

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/m3/6H/3W-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - changes in structure or function of salivary glands Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0523305 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4026 No. of Facilities: 64 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1427 (estimated) No. of Female Employees: 734 (estimated)

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三溴苯酚安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317-H319-H400

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R20/22;R36/37/38;R51/53

[ 安全声明 (欧洲) ]:
S26-S36-S61-S37/39-S45-S36/37-S16-S7-S24/25-S23-S53

[ 危险品运输编码 ]:
UN 1230 3/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
SN1225000

[ 包装等级 ]:
I; II; III

[ 海关编码 ]:
2908199090

三溴苯酚合成路线

详细合成路线

三溴苯酚上下游产品

三溴苯酚上游产品

三溴苯酚下游产品

三溴苯酚制备

1.将苯酚加入反应釜，搅拌下加水溶解并升温至60℃，滴加溴素，滴加完毕后继续搅拌30min。然后冷至40℃，进行过滤，滤饼用水洗至中性即得粗品。将粗品溶于70℃乙醇中，加入活性炭脱色，过滤后，将等量的水与滤液混合，即析出针状结晶即为成品。收率约96%。

2.生产三溴苯酚的工艺路线主要有以下3种。
（1）直接溴化法（苯酚溴水氧化法）目前国内采用传统工艺———利用溴水的氧化及取代的双重特性，与苯酚发生反应，生成白色的三溴苯酚沉淀。其工艺过程如下所述。
①制备　将苯酚溶于水中，在搅拌下缓慢滴加等化学反应当量的溴水（KBr作为助溶剂），控制温度为60℃，待滴加完毕，反应30min，冷却至40℃，过滤，用稀的亚硫酸氢钠水溶液洗涤，再用水洗涤至中性，干燥得2,4,6-三溴苯酚粗品。

②精制　将上述粗晶溶于热的无水乙醇中，加活性炭脱色，过滤后，将等量的水与滤液混合，即析出针状结晶产品，收率为96%。
③溴化氢的回收　将0.2mol的苯溶于水中在激烈搅拌下滴加0.3mol的溴水，滴加完毕缓慢通入0.3mol氯气，反应完全后过滤，用稀的亚硫酸氢钠水溶液洗涤，再用水洗涤至中性，干燥得产品。

3.氯化溴法　该法是以卤代烃为溶剂，以氯化溴代替溴素与苯酚进行反应。生产中首先要合成氯化溴，其次在氯化溴与苯酚溶液反应的过程中会产生大量的氯化氢，易在反应体系中造成积累，从而影响反应速度和产品质量。

4.氧化溴化法　该法是将苯酚与溴素进行溴化反应所生成的溴化氢用氧化剂（双氧水、氯气）氧化成溴素，进而继续参与反应。该法是国内外目前采用较多的方法。

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三溴苯酚海关

[ 海关编码 ]: 2908199090

[ 中文概述 ]:
HS:2908199090 其他酚及酚醇的仅含卤素取代基的衍生物及其盐增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%

三溴苯酚文献

Concurrent degradation of tetrabromobisphenol A byOchrobactrumsp. T under aerobic condition and estrogenic transition during these processes

Ecotoxicol. Environ. Saf. 104 , 220-5, (2014)

The effect of concurrent degradation of tetrabromobisphenol A (TBBPA) by the strain Ochrobactrum sp. T under aerobic condition was investigated. The results demonstrated that four extra energy source-...

Self-Assembly of a Tripod Aromatic Rod into Stacked Planar Networks.

Chemistry 21 , 11836-42, (2015)

Threefold symmetric rigid-core molecules with an internally grafted poly(ethylene oxide) (PEO) chain were synthesized, and their self-assembled structures were characterized using differential scannin...

Structural and kinetic study of an internal substrate binding site in dehaloperoxidase-hemoglobin A from Amphitrite ornata.

Biochemistry 52(14) , 2427-39, (2013)

X-ray crystal structures of dehaloperoxidase-hemoglobin A (DHP A) from Amphitrite ornata soaked with substrate, 2,4,6-tribromophenol (2,4,6-TBP), in buffer solvent with added methanol (MeOH), 2-propan...

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三溴苯酚

三溴苯酚用途

三溴苯酚名称

三溴苯酚物理化学性质

三溴苯酚MSDS

详细MSDS(安全技术说明书)

三溴苯酚毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

三溴苯酚安全信息

三溴苯酚合成路线

详细合成路线

三溴苯酚上下游产品

三溴苯酚上游产品

三溴苯酚下游产品

三溴苯酚制备

三溴苯酚海关

三溴苯酚文献

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