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3-[(2-环己基-2-羟乙基)氨基]-2,5-二氧代-1-(苯甲基)-4-咪唑啶庚酸

用途

BW A868C是乙内酰脲化合物,是BW245C结构类似物。BW A868C是一种选择性和有效的竞争性前列腺素D2(PGD2)拮抗剂。BW A868C对其他前列腺素受体(IP、EP1、EP2、TP和FP)没有影响[1]。

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名称

[ CAS 号 ]:
118675-50-6

[ 中文名 ]:
3-[(2-环己基-2-羟乙基)氨基]-2,5-二氧代-1-(苯甲基)-4-咪唑啶庚酸

[ 英文名 ]:
BW A868C

[英文别名 ]:

BW A868C

生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体

[ 靶点 ]

PGD2

[体外研究]

BW A868C拮抗前苷元D2和BW245C诱导的人血小板腺苷酸环化酶激活[1]。

[参考文献]

[1]. H Giles, et al. The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. Br J Pharmacol. 1989 Feb;96(2):291-300.

物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
638.1±65.0 °C at 760 mmHg

[ 分子式 ]:
C₂₅H₃₇N₃O₅

[ 分子量 ]:
459.578

[ 闪点 ]:
339.7±34.3 °C

[ 精确质量 ]:
459.273315

[ PSA ]:
110.18000

[ LogP ]:
3.31

[ 蒸汽压 ]:
0.0±2.0 mmHg at 25°C

[ 折射率 ]:
1.593

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

文献

Multiplexed phosphospecific flow cytometry enables large-scale signaling profiling and drug screening in blood platelets.

J. Thromb. Haemost. 12(10) , 1733-43, (2014)

Dissecting the signaling events that contribute to platelet activation will increase our understanding of platelet function and aid in the development of new antiplatelet agents. However, high-through...

Genetic validation of a therapeutic target in a mouse model of ALS.

Sci. Transl. Med. 6(248) , 248ra104, (2014)

Neurons produced from stem cells have emerged as a tool to identify new therapeutic targets for neurological diseases such as amyotrophic lateral sclerosis (ALS). However, it remains unclear to what e...

Pro-migratory actions of the prostacyclin receptor in human breast cancer cells that over-express cyclooxygenase-2.

Biochem. Pharmacol. 96 , 306-14, (2015)

Metastasis is the major cause of death in cancer patients. Elevated expression of cyclooxygenase-2 (COX-2) is observed in many human cancers and over-production of downstream prostaglandins (PGs) has ...

更多文献

3-[(2-环己基-2-羟乙基)氨基]-2,5-二氧代-1-(苯甲基)-4-咪唑啶庚酸

用途

名称

生物活性

物理化学性质

安全信息

文献

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