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滨蒿內酯

滨蒿內酯用途

Scoparone 从毛蒿中分离出来的,具有抗凝血,抗血管舒张作用,抗炎活性。

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滨蒿內酯名称

[ CAS 号 ]:
120-08-1

[ 中文名 ]:
6,7-二甲氧基香豆素

[ 英文名 ]:
Scoparone

[中文别名 ]:

[英文别名 ]:

MFCD00006871
6,7-Dimethoxy-chromen-2-one
Scoparone
EINECS 204-369-0
Dimethylesculetin
6,7-dimethoxychromen-2-one
6,7-Dimethoxy-2H-chromen-2-one
2H-1-Benzopyran-2-one, 6,7-dimethoxy-

滨蒿內酯生物活性

[ 描述 ]:

Scoparone 从毛蒿中分离出来的,具有抗凝血,抗血管舒张作用,抗炎活性。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体外研究]

Scoparone(0-0.4 nM；24-48小时)在0.4 nM时对PSC增殖产生最大抑制作用[1]。

[体内研究]

Scoparone(口服给药；30 mg/kg,60 mg/kg；4周)极大地改善了DBTC诱导的胰腺炎大鼠胰腺重量减轻[1]。动物模型：慢性胰腺炎(CP)大鼠模型[1]剂量：30 mg/kg,60 mg/kg给药：口服给药；30 mg/kg,60 mg/kg；4周结果：防止胰腺损伤

[参考文献]

[1]. Xu M, et al. Scoparone Protects Against Pancreatic Fibrosis via TGF-β/Smad Signaling in Rats. Cell Physiol Biochem. 2016;40(1-2):277-286. Epub 2016 Nov 18.

滨蒿內酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
369.2±42.0 °C at 760 mmHg

[ 熔点 ]:
145°C

[ 分子式 ]:
C₁₁H₁₀O₄

[ 分子量 ]:
206.195

[ 闪点 ]:
166.8±27.9 °C

[ 精确质量 ]:
206.057907

[ PSA ]:
48.67000

[ LogP ]:
1.60

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.557

[ 储存条件 ]:
室温

滨蒿內酯MSDS

滨蒿內酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN6550000

CHEMICAL NAME :: Coumarin, 6,7-dimethoxy-

CAS REGISTRY NUMBER :: 120-08-1

BEILSTEIN REFERENCE NO. :: 0169572

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C11-H10-O4

MOLECULAR WEIGHT :: 206.21

WISWESSER LINE NOTATION :: T66 BOVJ HO1 IO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 292 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,550,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 190 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,550,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,550,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - alteration of classical conditioning Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 60,763,1972 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1180 mg/kg

SEX/DURATION :: male 8 week(s) pre-mating female 2 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Newborn - delayed effects

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 17,740,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 725 mg/kg

SEX/DURATION :: female 15-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 17,740,1979

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滨蒿內酯安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H319

[ 警示性声明 ]:
P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
S27/28-S36/37/39-S45-S26

[ 危险品运输编码 ]:
2811

[ RTECS号 ]:
GN6550000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2932209090

滨蒿內酯合成路线

滨蒿內酯上下游产品

滨蒿內酯上游产品

滨蒿內酯下游产品

滨蒿內酯制备

由6,7-二羟基香豆素（C9H6O4，[ 305-01-1 ]与硫酸二甲酯反应而得

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滨蒿內酯海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

滨蒿內酯文献

Green tea inhibited the elimination of nephro-cardiovascular toxins and deteriorated the renal function in rats with renal failure.

Sci. Rep. 5 , 16226, (2015)

Chronic kidney disease (CKD) is a major health problem worldwide. Indoxyl sulfate (IS) and p-cresyl sulfate (PCS) are highly protein-bound nephro-cardiovascular toxins, which are not efficiently remov...

7-substituted coumarins inhibit proliferation and migration of laryngeal cancer cells in vitro.

Anticancer Res. 33(10) , 4347-56, (2013)

Coumarins are a large group of naturally-occurring compounds with a wide range of biological properties, including anticancer activity. 7-Substituted coumarins (umbelliferone, scoparone, and herniarin...

Effects of scoparone on dopamine release in PC12 cells.

Fitoterapia 81(6) , 497-502, (2010)

The effects of scoparone on dopamine release in PC12 cells were investigated. Scoparone at 50-200 microM increased dopamine release into the culture medium. However, the released levels of dopamine by...

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滨蒿內酯

滨蒿內酯用途

滨蒿內酯名称

滨蒿內酯生物活性

滨蒿內酯物理化学性质

滨蒿內酯MSDS

详细MSDS(安全技术说明书)

滨蒿內酯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

滨蒿內酯安全信息

滨蒿內酯合成路线

详细合成路线

滨蒿內酯上下游产品

滨蒿內酯上游产品

滨蒿內酯下游产品

滨蒿內酯制备

滨蒿內酯海关

滨蒿內酯文献

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