2-甲氧基-5-甲基苯胺

2-甲氧基-5-甲基苯胺用途

【用途一】
适用于直接、分散、活性染料的合成
【用途二】
本品是一种染料中间体。在直接染料方面用于合成C.I.29050、29065、27885等，在酸性染料方面用于合成C.I.14940、14965等，还用于制造分散大红GC、直接耐晒蓝3RLL、直接黑D、活性黄棕K-GR、阳离子黄4G等。
【用途三】
本品是以种染料中间体。在直接染料方面用于合成C.I.29050；29065；27885等，在酸性染料方面用于合成C.I.14940；14965等，还用于制造分散大红GC；直接耐晒蓝3RLL；直接黑D；活性黄棕K-GR；阳离子黄4G等。

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2-甲氧基-5-甲基苯胺名称

[ CAS 号 ]:
120-71-8

[ 中文名 ]:
2-甲氧基-5-甲基苯胺

[ 英文名 ]:
Para-Cresidine

[中文别名 ]:

[英文别名 ]:

Para-Cresidine
EINECS 204-419-1
6-Methoxy-m-toluidine
2-Methoxy-5-methylbenzenamine
2-Methoxy-5-methylaniline
Cresidine
Benzenamine,2-methoxy-5-methyl
5-Methyl-o-anisidine
Para Cresidine
p-cresidine

2-甲氧基-5-甲基苯胺物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
235.4±20.0 °C at 760 mmHg

[ 熔点 ]:
50-52 °C(lit.)

[ 分子式 ]:
C₈H₁₁NO

[ 分子量 ]:
137.179

[ 闪点 ]:
102.1±15.0 °C

[ 精确质量 ]:
137.084061

[ PSA ]:
35.25000

[ LogP ]:
1.55

[ 外观性状 ]:
黄色至棕色结晶固体

[ 蒸汽密度 ]:
4.7 (vs air)

[ 蒸汽压 ]:
0.1±0.5 mmHg at 25°C

[ 折射率 ]:
1.549

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
Slightly soluble in hot water.

2-甲氧基-5-甲基苯胺MSDS

详细MSDS(安全技术说明书)

2-甲氧基-5-甲基苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ6720000

CHEMICAL NAME :: o-Anisidine, 5-methyl-

CAS REGISTRY NUMBER :: 120-71-8

BEILSTEIN REFERENCE NO. :: 0637071

LAST UPDATED :: 199806

DATA ITEMS CITED :: 27

MOLECULAR FORMULA :: C8-H11-N-O

MOLECULAR WEIGHT :: 137.20

WISWESSER LINE NOTATION :: ZR C1 FO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 364 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Brain and Coverings - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 355 gm/kg/92W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 182 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Brain and Coverings - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3640 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1607 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7280 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2961 gm/kg/92W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 364 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 437 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 595 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 412,155,1998 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,91,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,91,1982 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE;Carcinogen JAN 1993

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2-甲氧基-5-甲基苯胺安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H319-H350

[ 警示性声明 ]:
P201-P305 + P351 + P338-P308 + P313

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R22;R45

[ 安全声明 (欧洲) ]:
S53-S45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
BZ6720000

[ 包装等级 ]:
I; II; III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2922199090

2-甲氧基-5-甲基苯胺合成路线

详细合成路线

2-甲氧基-5-甲基苯胺上下游产品

2-甲氧基-5-甲基苯胺上游产品

2-甲氧基-5-甲基苯胺下游产品

2-甲氧基-5-甲基苯胺制备

【方法一】
1.由对氯甲苯硝化、甲氧基化、还原而得。在15-20℃将混酸加入对氯甲苯中，在30℃搅拌2h，用水稀释，分离废酸，水洗得4-氯-3-硝基甲苯（收率30.6%）和4-氯-2-硝基甲苯（收率56.7%），用分馏和结晶法将两者分离，得4-氯-3-硝基甲苯。将其与甲醇及甲醇钠溶液反应，用硫酸中和分离，得3-硝基-4-甲氧基甲苯，收率85.6%。用水、铁粉、甲酸还原后，再用溶剂汽油多次萃取蒸馏而得。2.由对甲酚硝化得到2-硝基-4-甲酚，再与硫酸二甲酯甲基化为3-硝基-4-对甲氧基甲苯，最后用硫化碱还原而得。3.对氯-N,N-二乙基苄胺法　经硝化、甲氧基化、还原反应制得。

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2-甲氧基-5-甲基苯胺海关

[ 海关编码 ]: 2922299090

[ 中文概述 ]:
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

2-甲氧基-5-甲基苯胺文献

Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals.

Eur. J. Med. Chem. 44 , 3658-64, (2009)

A dataset comprising 55 chemicals with hepatocarcinogenic potency indices was collected from the Carcinogenic Potency Database with the aim of developing QSAR models enabling prediction of the above u...

Biopartitioning micellar chromatography to predict mutagenicity of aromatic amines.

Eur. J. Med. Chem. 42 , 1396-402, (2007)

Mutagenicity is a toxicity endpoint associated with the chronic exposure to chemicals. Aromatic amines have considerable industrial and environmental importance due to their widespread use in industry...

Chromosome 11 allelotypes reflect a mechanism of chemical carcinogenesis in heterozygous p53-deficient mice.

Carcinogenesis 22(1) , 89-98, (2001)

Mice heterozygous for a null p53 allele were administered three well-characterized carcinogens to learn more about mechanisms of carcinogenesis and to evaluate the p53-deficient mouse as a tool for id...

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2-甲氧基-5-甲基苯胺

2-甲氧基-5-甲基苯胺用途

2-甲氧基-5-甲基苯胺名称

2-甲氧基-5-甲基苯胺物理化学性质

2-甲氧基-5-甲基苯胺MSDS

详细MSDS(安全技术说明书)

2-甲氧基-5-甲基苯胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

2-甲氧基-5-甲基苯胺安全信息

2-甲氧基-5-甲基苯胺合成路线

详细合成路线

2-甲氧基-5-甲基苯胺上下游产品

2-甲氧基-5-甲基苯胺上游产品

2-甲氧基-5-甲基苯胺下游产品

2-甲氧基-5-甲基苯胺制备

2-甲氧基-5-甲基苯胺海关

2-甲氧基-5-甲基苯胺文献

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