< 生产厂家价格 >

CAY10621(SKI 5C)

CAY10621(SKI 5C)用途

CAY10621(SKI 5C；化合物5C)是一种特异性鞘氨醇激酶1(SPHK1)抑制剂,IC50为3.3μM。CAY10621对细胞毒性低。CAY10621具有抗肿瘤研究的潜力【1】。

点击显示

CAY10621(SKI 5C)名称

[ CAS 号 ]:
120005-55-2

[ 英文名 ]:
CAY10621(SKI 5C)

[英文别名 ]:

z-n-e-boc-l-lysine amide

CAY10621(SKI 5C)生物活性

[ 描述 ]:

CAY10621(SKI 5C；化合物5C)是一种特异性鞘氨醇激酶1(SPHK1)抑制剂,IC50为3.3μM。CAY10621对细胞毒性低。CAY10621具有抗肿瘤研究的潜力【1】。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 免疫及炎症 >> SPHK

[参考文献]

[1]. Lingkai Wong, et al. Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. J Med Chem. 2009 Jun 25;52(12):3618-26.

CAY10621(SKI 5C)物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
519.0±60.0 °C at 760 mmHg

[ 分子式 ]:
C₂₆H₄₅NO₄

[ 分子量 ]:
435.640

[ 闪点 ]:
267.7±32.9 °C

[ 精确质量 ]:
435.334869

[ PSA ]:
55.84000

[ LogP ]:
8.67

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.478

CAY10621(SKI 5C)MSDS

CAY10621(SKI 5C)安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

CAY10621(SKI 5C)合成路线

CAY10621(SKI 5C)上下游产品

CAY10621(SKI 5C)上游产品

CAY10621(SKI 5C)下游产品

CAY10621(SKI 5C)文献

Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/EDG1 axis in hepatocellular carcinoma.

Liver Int. 32(2) , 331-8, (2012)

Sphingosine kinase 1 (SphK1), which phosphorylates sphingosine to sphingosine-1-phosphate (S1P), is overexpressed in various types of cancers, and may act as an oncogene in tumorigenesis. However, lit...

更多文献