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3-吲哚丙烯酸

3-吲哚丙烯酸用途

有机合成。色氨酸的代谢产物。

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3-吲哚丙烯酸名称

[ CAS 号 ]:
1204-06-4

[ 中文名 ]:
3-吲哚丙烯酸(IAA)

[ 英文名 ]:
3-Indoleacrylic acid

[中文别名 ]:

[英文别名 ]:

3-(3-Indolyl)acrylic acid,IAA
2-Propenoic acid, 3-(1H-indol-2-yl)-, (2E)-
3-(3-Indolyl)acrylic acid IAA
(2E)-3-(1H-Indol-2-yl)acrylic acid
2-Propenoic acid,3-(1H-indol-3-yl)-
3-Indolylacrylic acid
3-Indoleacrylic Acid
3-(3-Indolyl)acrylic Acid
EINECS 214-872-7
MFCD00005633

3-吲哚丙烯酸生物活性

[ 描述 ]:

3-Indoleacrylic acid 是一种高效抗藻剂。3-Indoleacrylic acid 可增加东海虾中活性氧 (ROS) 的产生,并抑制所有营养同化基因、下调核酮糖-1,5-二磷酸羧化酶/加氧酶 II 和细胞色素 f 基因的功能。

[ 相关类别 ]:

研究领域 >> 其他

[参考文献]

[1]. Kokoette Effiong, et al. 3-Indoleacrylic acid from canola straw as a promising antialgal agent - Inhibition effect and mechanism on bloom-forming Prorocentrum donghaiense. Mar Pollut Bull. 2022 May:178:113657.

3-吲哚丙烯酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
432.8±20.0 °C at 760 mmHg

[ 熔点 ]:
180-186ºC

[ 分子式 ]:
C₁₁H₉NO₂

[ 分子量 ]:
187.195

[ 闪点 ]:
215.6±21.8 °C

[ 精确质量 ]:
187.063324

[ PSA ]:
53.09000

[ LogP ]:
2.34

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.750

[ 储存条件 ]:
0-6°C

[ 水溶解性 ]:
freely soluble

3-吲哚丙烯酸MSDS

3-吲哚丙烯酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL3680000

CHEMICAL NAME :: Indole-3-acrylic acid

CAS REGISTRY NUMBER :: 1204-06-4

BEILSTEIN REFERENCE NO. :: 0006317

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C11-H9-N-O2

MOLECULAR WEIGHT :: 187.21

WISWESSER LINE NOTATION :: T56 BMJ D1U1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1100 mg/kg/13W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Blood - leukemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 1600 mg/kg/10W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Endocrine - adrenal cortex tumors Blood - tumors

MUTATION DATA

TEST SYSTEM :: Primate - monkey

DOSE/DURATION :: 15 mg/kg/2D (Intermittent)

REFERENCE :: TSITAQ Tsitologiya. Cytology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1959- Volume(issue)/page/year: 15,1505,1973

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3-吲哚丙烯酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NL3680000

[ 海关编码 ]:
2933990090

3-吲哚丙烯酸合成路线

3-吲哚丙烯酸上下游产品

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3-吲哚丙烯酸下游产品

3-吲哚丙烯酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3-吲哚丙烯酸文献

Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.

J. Med. Chem. 54 , 5320, (2011)

Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO) is an important mechanism of peripheral immune tolerance contributing to tumoral immune resistance. IDO inhibition is thus an active...

Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K.

J. Med. Chem. 52 , 2786-93, (2009)

Human kynurenine aminotransferase I (hKAT I) catalyzes the formation of kynurenic acid, a neuroactive compound. Here, we report three high-resolution crystal structures (1.50-1.55 A) of hKAT I that ar...

NMR studies of the mode of binding of corepressors and inducers to Escherichia coli trp repressor.

Eur. J. Biochem. 235(3) , 804-13, (1996)

The binding of the corepressors tryptophan and 5-methyltryptophan and of the inducers 3-indolepropionate, 3-indoleacrylate and 5-methylindole to the Escherichia coli trp repressor have been studied by...

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