丙二酸

用途一：主要用于医药中间体，也用于香料、粘合剂、树脂添加剂、电镀抛光剂等用途二：用作络合剂，也用于巴比土盐的制备等用途三：丙二酸是杀菌剂稻瘟灵的中间体，也是植物生长调节剂吲熟酯的中间体。用途四：丙二酸及其酯主要用于香料、粘合剂、树脂添加剂、医药中间体、电镀抛光剂、爆炸控制剂、热焊接助熔添加剂等方面。在医药工业中用于生产鲁米那、巴比妥、维生素B1、维生素B2、维生素B6、苯基保泰松、氨基酸等。丙二酸用作铝表面处理剂，由于加热分解时只生成水和二氧化碳，因而没有污染问题。在这一点上，与过去采用的甲酸等酸型处理剂相比，具有很大的优点。

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
386.8±25.0 °C at 760 mmHg

[ 熔点 ]:
132-135 °C (dec.)(lit.)

[ 分子式 ]:
C₃H₄O₄

[ 分子量 ]:
104.062

[ 闪点 ]:
201.9±19.7 °C

[ 精确质量 ]:
104.010956

[ PSA ]:
74.60000

[ LogP ]:
-0.56

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.479

[ 储存条件 ]:
Store at RT.

[ 稳定性 ]:
Stable. Incompatible with oxidizing agents, reducing agents, bases.

[ 水溶解性 ]:
1400 g/L (20 ºC)

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

OO0175000

CHEMICAL NAME :

Malonic acid

CAS REGISTRY NUMBER :

141-82-2

BEILSTEIN REFERENCE NO. :

1751370

LAST UPDATED :

199701

DATA ITEMS CITED :

11

MOLECULAR FORMULA :

C3-H4-O4

MOLECULAR WEIGHT :

104.07

WISWESSER LINE NOTATION :

QV1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1310 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>8900 mg/m3/1H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1500 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

4 gm/kg

TOXIC EFFECTS :

Tumorigenic - active as anti-cancer agent

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

300 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

10 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :

Rodent - rat

DOSE/DURATION :

10080 mg/kg/6W

REFERENCE :

CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 9,387,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4746 No. of Facilities: 46 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1913 (estimated) No. of Female Employees: 272 (estimated)

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/39-S37/39

[ 危险品运输编码 ]:
3261

[ WGK德国 ]:
1

[ RTECS号 ]:
OO0175000

[ 包装等级 ]:
III

[ 海关编码 ]:
2917190090

详细合成路线

丙二酸上游产品

丙二酸下游产品

1.工业上常用水解氰乙酸或丙二酸二乙酯的方法制丙二酸。由于丙二酸本身不很稳定，它在有机合成中是通过丙二酸二乙酯进行的。丙二酸以钙盐形式存在于甜菜根中，甜菜制糖的深缩罐里沉积的水垢即丙二酸钙。丙二酸是一种新陈代谢的中间体，其衍生物具有生物活性，丙二酸酯尤其是丙二酸二乙酯与乙酰乙酸乙酯一样，是有机合成极为重要的中间体。制备丙二酸及其衍生物的中间体是氰乙酸，氰乙酸经水解转化成游离丙二酸，一般不加分离，直接进行酯化。通常转化为二乙酯，而游离丙二酸通常由丙二酸二乙酯水解制得。

2.其制备方法是将氯乙酸在反应釜中加入碳酸钠水溶液使成氯乙酸钠水溶液，然后再缓慢地滴加30%氰化钠溶液，在既定的温度下进行，使反应生成氰乙酸钠。氰化反应完成后，加氢氧化钠升温水解，生成丙二酸钠溶液，浓缩，然后滴加硫酸酸化生成丙二酸，过滤、干燥得产品。

3. 烟草：FC，54；FC，50；BU，26；FC，38。

[ 海关编码 ]: 2917190090

[ 中文概述 ]:
2917190090 其他无环多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Urinary metabolic fingerprinting of mice with diet-induced metabolic derangements by parallel dual secondary column-dual detection two-dimensional comprehensive gas chromatography.

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This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse u...

Hydrolytic pathway of 5-fluorouracil in aqueous solutions for clinical use.

J. Pharm. Biomed. Anal. 98 , 446-62, (2014)

The purpose of the study was to investigate the degradation pathway of 5-fluorouracil (FU) in the situation of commercial formulations for clinical use, namely FU dissolved in sodium hydroxide (NaOH) ...

Electrochemistry and speciation of Au(+) in a deep eutectic solvent: growth and morphology of galvanic immersion coatings.

Phys. Chem. Chem. Phys. 17 , 30540-50, (2015)

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：丙二酸

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公司名：南通润丰石油化工有限公司

区域：南通市崇川区

价格：
￥需询单/1kg ￥需询单/1ton

联系人：曹经理

产品详情：丙二酸

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公司名：云南西力生物技术股份有限公司

区域：昆明市盘龙区

价格：
￥需询单/5mg

联系人：郑雪平

产品详情：丙二酸

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥198.0/500g ￥80.0/100g ￥88.0/20mg

联系人：刘佳

产品详情：丙二酸

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公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥489.0/100mg ￥989.0/500mg ￥需询单/1g ￥需询单/1g

联系人：李先生

产品详情：Malonic acid

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