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4-氨基-6-氯-1,3-苯二磺酰胺

4-氨基-6-氯-1,3-苯二磺酰胺用途

用作医药中间体，可用于合成氢氯噻嗪等原料药

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4-氨基-6-氯-1,3-苯二磺酰胺名称

[ CAS 号 ]:
121-30-2

[ 中文名 ]:
5-氯-2,4-二磺酰胺基苯胺

[ 英文名 ]:
4-Amino-6-chlorobenzene-1,3-disulfonamide

[中文别名 ]:

[英文别名 ]:

Salmid
Idorese
1-amino-3-chloro-4,6-benzenedisulfonamide
3-chloroanilino-4,6-disulphonamide
1,3-Benzenedisulfonamide, 4-amino-6-chloro-
5-Chloro-2,4-disulfamoylaniline
5-Chloro-2,4-bis(sulfonamide)aniline
2,4-disulfamoyl-5-chloroaniline
Chloraminophenamide
Chloroaminophenamide

4-氨基-6-氯-1,3-苯二磺酰胺物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
614.4±65.0 °C at 760 mmHg

[ 熔点 ]:
257-261 °C(lit.)

[ 分子式 ]:
C₆H₈ClN₃O₄S₂

[ 分子量 ]:
285.728

[ 闪点 ]:
325.4±34.3 °C

[ 精确质量 ]:
284.964478

[ PSA ]:
163.10000

[ LogP ]:
0.14

[ 外观性状 ]:
略黄色晶体

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.666

[ 储存条件 ]:
Refrigerator

4-氨基-6-氯-1,3-苯二磺酰胺MSDS

4-氨基-6-氯-1,3-苯二磺酰胺安全信息

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R23/24;R33

[ 安全声明 (欧洲) ]:
S28-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2935009090

4-氨基-6-氯-1,3-苯二磺酰胺合成路线

4-氨基-6-氯-1,3-苯二磺酰胺上下游产品

4-氨基-6-氯-1,3-苯二磺酰胺上游产品

4-氨基-6-氯-1,3-苯二磺酰胺下游产品

4-氨基-6-氯-1,3-苯二磺酰胺制备

二、生产方法简述

间氯苯胺经氯磺酸氯磺化；液氯胺化而得。

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4-氨基-6-氯-1,3-苯二磺酰胺海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

4-氨基-6-氯-1,3-苯二磺酰胺文献

Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.

Bioorg. Med. Chem. Lett. 16 , 2182-8, (2006)

A library of sulfonamides/sulfamates has been investigated for the inhibition of the carboxyterminal truncated form of the alpha-carbonic anhydrase (CA, EC 4.2.1.1) isolated from the gastric pathogen ...

Mass spectrometric behavior of thiazide-based diuretics after electrospray ionization and collision-induced dissociation.

Anal. Chem. 74(15) , 3802-8, (2002)

The mass spectrometric behavior of 21 thiazide-based compounds after electrospray ionization in the negative ion mode and collision-induced dissociation was investigated on a triple-stage quadrupole m...

Detection of urinary markers for thiazide diuretics after oral administration of hydrochlorothiazide and altizide-relevance to doping control analysis

J. Chromatogr. A. 1216(12) , 2466-73, (2009)

In sports, thiazide diuretics are used to flush out previously taken prohibited substances with forced diuresis and in sports where weight classes are involved to achieve acute weight loss. Thiazide d...

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