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三氯噻嗪

三氯噻嗪用途

Trichlormethiazide是噻嗪类利尿剂。

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三氯噻嗪名称

[ CAS 号 ]:
133-67-5

[ 中文名 ]:
三氯噻嗪

[ 英文名 ]:
Trichlormethiazide

[中文别名 ]:

[英文别名 ]:

Metahydrin
Trichloromethiazide
Diu-Hydrin
Esmarin
Triflumen
Achletin,Diu-Hydrin,Triflumen
Carvacron
Diurese
MFCD00057315
Achletin

三氯噻嗪生物活性

[ 描述 ]:

Trichlormethiazide是噻嗪类利尿剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钠通道

研究领域 >> 代谢疾病

[参考文献]

[1]. Fuchs, M., B.E. Newman, and R.H. Seller, The clinical pharmacology of trichlormethiazide (Naqua). Curr Ther Res Clin Exp, 1961. 3: p. 116-24.

[2]. Reisman, E.E., Jr., Clinical experience with trichlormethiazide in edema. Angiology, 1963. 14: p. 59-63.

[3]. West, R.O., A clinical and statistical study of the effect of trichlormethiazide on blood pressure. Med Ann Dist Columbia, 1962. 31: p. 574-7.

[相关活性小分子]

三氯噻嗪物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
631.3±65.0 °C at 760 mmHg

[ 熔点 ]:
248-250ºC

[ 分子式 ]:
C₈H₈Cl₃N₃O₄S₂

[ 分子量 ]:
380.656

[ 闪点 ]:
335.6±34.3 °C

[ 精确质量 ]:
378.902191

[ PSA ]:
135.12000

[ LogP ]:
0.24

[ 外观性状 ]:
白色-类白色晶体-粉末

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.625

[ 储存条件 ]:
室温

三氯噻嗪MSDS

详细MSDS(安全技术说明书)

三氯噻嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DK8925000

CHEMICAL NAME :: 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide

CAS REGISTRY NUMBER :: 133-67-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C8-H8-Cl3-N3-O4-S2

MOLECULAR WEIGHT :: 380.66

WISWESSER LINE NOTATION :: T66 BSWM EM DHJ DYGG HG ISZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 3320 ug/kg/7W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in potassium

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 920 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 540 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 182 gm/kg/1Y-I

TOXIC EFFECTS :: Cardiac - EKG changes not diagnostic of specified effects Blood - other changes Nutritional and Gross Metabolic - changes in potassium

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 560 mg/L

REFERENCE :: GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5670 No. of Facilities: 26 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1324 (estimated) No. of Female Employees: 667 (estimated)

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三氯噻嗪安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H334

[ 警示性声明 ]:
P261-P280-P284-P304 + P340-P342 + P311

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R42/43

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
DK8925000

[ 海关编码 ]:
2935009090

三氯噻嗪合成路线

详细合成路线

三氯噻嗪上下游产品

三氯噻嗪上游产品

三氯噻嗪下游产品

三氯噻嗪海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%