对硝基苯甲酰氯

用于医药、染料和有机合成

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
277.8±13.0 °C at 760 mmHg

[ 熔点 ]:
71-74 °C(lit.)

[ 分子式 ]:
C₇H₄ClNO₃

[ 分子量 ]:
185.565

[ 闪点 ]:
121.8±19.8 °C

[ 精确质量 ]:
184.987976

[ PSA ]:
62.89000

[ LogP ]:
2.17

[ 外观性状 ]:
黄色晶体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.589

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂分开存放

[ 稳定性 ]:
Stability Stable, but moisture sensitive. Combustible. Incompatible with water, alcohols, strong oxidizing agents, strong bases.

[ 水溶解性 ]:
Decomposes

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

DM6651000

CHEMICAL NAME :

Benzoyl chloride, p-nitro-

CAS REGISTRY NUMBER :

122-04-3

BEILSTEIN REFERENCE NO. :

0473192

LAST UPDATED :

199710

DATA ITEMS CITED :

9

MOLECULAR FORMULA :

C7-H4-Cl-N-O3

MOLECULAR WEIGHT :

185.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5600 mg/kg

TOXIC EFFECTS :

Behavioral - muscle weakness Behavioral - ataxia Behavioral - muscle contraction or spasticity

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

3440 mg/kg

TOXIC EFFECTS :

Behavioral - muscle weakness Behavioral - ataxia Behavioral - muscle contraction or spasticity

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

4750 mg/kg

TOXIC EFFECTS :

Behavioral - muscle weakness Behavioral - ataxia Behavioral - muscle contraction or spasticity

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

16800 mg/kg/30D-I

TOXIC EFFECTS :

Blood - other changes

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

11830 ug/m3/4H/17W-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - other changes Blood - pigmented or nucleated red blood cells Blood - changes in spleen

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

11830 ug/m3/4H

SEX/DURATION :

male 16 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

MUTATION DATA

TYPE OF TEST :

Mutation in microorganisms

TEST SYSTEM :

Bacteria - Salmonella typhimurium

DOSE/DURATION :

3 ug/plate

REFERENCE :

ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9(Suppl 9),1,1987

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 3261 8/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
DM6651000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2916399090

详细合成路线

对硝基苯甲酰氯上游产品

对硝基苯甲酰氯下游产品

1.以对硝基苯甲酸为原料，用氯化亚砜或三氯氧磷或光气进行氯化都可以制得该品。将对硝基苯甲酸和三氯氧磷加热回流24h，减压回收三氯氧磷，即生成对硝基苯甲酰氯。或将对硝基苯甲酸和氯化亚砜加热至90℃，回流30-40h，然后冷却析出对硝基本甲酰氯结晶。收率90%。将光气通入熔融的对硝基苯甲酸，将光气化反应物进行减压蒸馏，也可以获得对硝基苯甲酰氯。

2.将干燥的对硝基苯甲酸与五氯化磷放在油浴中加热，至反应完全后，减压回收三氯氧磷。然后，真空蒸馏将残留物蒸出即为粗品。将粗品熔化后加入四氯化碳，趁热过滤，冷却结晶，即为成品。
过程方程式为：

[ 海关编码 ]: 2916399090

[ 中文概述 ]:
2916399090 其他芳香一元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains.

J. Med. Chem. 49(9) , 2725-30, (2006)

A novel series of benzofuran derivatives as potential positron emission tomography (PET) tracers targeting amyloid plaques in Alzheimer's disease (AD) were synthesized and evaluated. The syntheses of ...

Liquid chromatography-mass spectrometric assay of androstenediol in prostatic tissue: influence of androgen deprivation therapy on its level.

Steroids 71(11-12) , 1007-13, (2006)

Androstenediol (Adiol, androst-5-ene-3beta,17beta-diol) is suspected of being an endogenous proliferation agent of prostate cancer (PCa) even after androgen deprivation therapy (ADT). A liquid chromat...

[Experimental establishment of the maximum permissible concentration of para-nitrobenzoylchloride in the air of a work area].

Gig. Tr. Prof. Zabol. (9) , 47-8, (1984)

更多文献

公司名：上海化源生化科技有限公司

区域：上海市普陀区

价格：

联系人：化源

产品详情：对硝基苯甲酰氯

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥98.0/100g ￥318.0/500g

联系人：刘佳

产品详情：对硝基苯甲酰氯

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥1708.0/500g ￥171.0/100g ￥需询单/1g ￥需询单/1g

联系人：阿拉丁

产品详情：4-硝基苯甲酰氯

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