二苯胺

二苯胺用途

【用途一】
主要用于制造橡胶防老剂、火药安定剂，也用作染料和农药的中间体
【用途二】
用作分析试剂、氧化还原指示剂和液体干燥剂，也用于有机染料的合成
【用途三】
二苯胺的主要用途是在橡胶化学品领域，用于抗氧剂、抑制剂、促进剂的生产；作为染料中间体，可生产酸性黄G、酸性橙N、酸性墨水蓝A，分散蓝5R等产品；也是塑料稳定剂、兽药硫化二苯胺、吩噻嗪的中间体。二苯胺还用作硝化棉及无烟炸药的稳定剂、分析试剂、氧化还原指示剂和液体干燥剂。
【用途四】
硝酸盐、氯酸盐和其他氧化性物质的检定。铱的催化测定。硝酸盐的光度测定。氧化还原指示剂。单倍体育种培养基。制造染料。是硝化纤维素、炸药、火棉的稳定剂。

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二苯胺名称

[ CAS 号 ]:
122-39-4

[ 中文名 ]:
二苯胺

[ 英文名 ]:
Diphenylamine

[中文别名 ]:

[英文别名 ]:

N-Phenyl-Aniline
Diphenylamine,Redox-indicator
Aniline, N-phenyl-
EINECS 204-539-4
DIPHENYL AMINE
Diphenylamine
Diphenyl-amine
N-Phenylbenzenamine
MFCD00003014
Benzenamine, N-phenyl-

二苯胺物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
302.0±0.0 °C at 760 mmHg

[ 熔点 ]:
52 °C

[ 分子式 ]:
C₁₂H₁₁N

[ 分子量 ]:
169.222

[ 闪点 ]:
152.8±0.0 °C

[ 精确质量 ]:
169.089142

[ PSA ]:
12.03000

[ LogP ]:
2.97

[ 外观性状 ]:
白色晶体或粉末

[ 蒸汽密度 ]:
5.82 (vs air)

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.634

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 稳定性 ]:
Stable; may discolour on exposure to light. Incompatible with strong acids, strong oxidizing agents.

[ 水溶解性 ]:
Slightly soluble. 0.03 g/100 mL

二苯胺MSDS

详细MSDS(安全技术说明书)

二苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JJ7800000

CHEMICAL NAME :: Diphenylamine

CAS REGISTRY NUMBER :: 122-39-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 32

MOLECULAR FORMULA :: C12-H11-N

MOLECULAR WEIGHT :: 169.24

WISWESSER LINE NOTATION :: RMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 41(5),21,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1750 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 41(5),21,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C112,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 40(10),114,1975 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9660 mg/kg/92W-C

TOXIC EFFECTS :: Blood - other changes

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,302,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28 gm/kg/28D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in bone marrow (not otherwise specified) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (107),56,1989 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 7500 mg/kg

SEX/DURATION :: female 17-22 day(s) after conception

REFERENCE :: PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 4,448,1970 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 15,121,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 10 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,95,1971 OSHA PEL (Construc):8H TWA 10 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 10 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 mg/m3 JAN 1993 OEL-BELGIUM:TWA 10 mg/m3 JAN 1993 OEL-DENMARK:TWA 5 mg/m3 JAN 1993 OEL-FRANCE:TWA 10 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 10 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 10 mg/m3;STEL 20 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIPHENYLAMINE-air:10H TWA 10 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 27615 No. of Facilities: 3217 (estimated) No. of Industries: 71 No. of Occupations: 55 No. of Employees: 50967 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 27615 No. of Facilities: 10880 (estimated) No. of Industries: 97 No. of Occupations: 78 No. of Employees: 155673 (estimated) No. of Female Employees: 20837 (estimated)

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二苯胺安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331-H373-H410

[ 警示性声明 ]:
P261-P273-P280-P301 + P310 + P330-P302 + P352 + P312-P403 + P233

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R23/24/25;R33;R50/53

[ 安全声明 (欧洲) ]:
S28-S36/37-S45-S60-S61-S28A-S16-S7

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
JJ7800000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2921440000

二苯胺合成路线

详细合成路线

二苯胺上下游产品

二苯胺上游产品

二苯胺下游产品

二苯胺制备

1.苯胺盐酸盐法由苯胺与苯胺盐酸盐缩合而得。

2.三氯化铝催化法以苯胺为原料，三氯化铝为催化剂，经缩合反应而得。

3.苯酚缩合法采用HD92催化剂，由苯酚与苯胺缩合而得。

4.苯胺以无水三氯化铝为催化剂，进行缩合反应。反应产物经盐酸盐析、氢氧化钠中合、煮洗、真空蒸馏、用乙醇结晶、分离即得成品。

5. 工业二苯胺经精制制得。 6. 用氰化钾洗涤工业二苯胺，与铁、其他金属络合后，与二苯胺分开。
7.在氮气流中把二苯胺减压蒸馏即得成品。

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二苯胺海关

[ 海关编码 ]: 2921440000

[ 中文概述 ]:
2921440000. 二苯胺及其衍生物以及它们的盐. 增值税率:17.0%. 退税率:17.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921440000. diphenylamine and its derivatives; salts thereof. VAT:17.0%. Tax rebate rate:17.0%. . MFN tariff:6.5%. General tariff:30.0%

二苯胺文献

Sol-gel-based silver nanoparticles-doped silica – Polydiphenylamine nanocomposite for micro-solid-phase extraction.

Anal. Chim. Acta 886 , 56-65, (2015)

A nanocomposite of silica-polydiphenylamine doped with silver nanoparticles (Ag-SiO2-PDPA) was successfully synthesized by the sol-gel process. For its preparation, PDPA was mixed with butanethiol cap...

DJ-1 upregulates anti-oxidant enzymes and attenuates hypoxia/re-oxygenation-induced oxidative stress by activation of the nuclear factor erythroid 2-like 2 signaling pathway.

Mol. Med. Report. 12 , 4734-42, (2015)

DJ-1 protein, as a multifunctional intracellular protein, has an important role in transcriptional regulation and anti-oxidant stress. A recent study by our group showed that DJ-1 can regulate the exp...

Prevention of myelosuppression and genotoxicity induced by cisplatin in murine bone marrow cells: effect of an organovanadium compound vanadium(III)-l-cysteine.

Mutagenesis 30 , 509-17, (2015)

Cisplatin (CDDP) is one of the first-line anticancer drugs indicated for use against various form of human malignancies; but, the therapeutic outcome of CDDP chemotherapy is limited due to the develop...

更多文献

二苯胺

二苯胺用途

二苯胺名称

二苯胺物理化学性质

二苯胺MSDS

详细MSDS(安全技术说明书)

二苯胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

二苯胺安全信息

二苯胺合成路线

详细合成路线

二苯胺上下游产品

二苯胺上游产品

二苯胺下游产品

二苯胺制备

二苯胺海关

二苯胺文献

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