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Tigecycline hydrate

Tigecycline hydrate用途

虎环素是一种广谱甘氨酸环素类抗生素。虎环素水合物具有抑菌作用,通过与细菌的30S核糖体亚单位结合来抑制蛋白质合成,从而在原核翻译过程中阻止氨酰tRNA进入核糖体的A位点。虎环素水合物对革兰氏阳性菌和革兰氏阴性菌的耐药菌株具有活性。

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Tigecycline hydrate名称

[ CAS 号 ]:
1229002-07-6

[ 英文名 ]:
Tigecycline hydrate

[英文别名 ]:

Tigecyclin
9-t-Butylglycylamido-minocycline hydrate
Tigecycline hydrate

Tigecycline hydrate生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 抗感染 >> 细菌

Tigecycline hydrate物理化学性质

[ 分子式 ]:
C₂₉H₃₉N₅O_8.xH₂O

[ 分子量 ]:
603.66400

[ 精确质量 ]:
603.29000

[ PSA ]:
219.47000

[ LogP ]:
2.48240

Tigecycline hydrate安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H319-H360

[ 警示性声明 ]:
P201-P305 + P351 + P338-P308 + P313

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
QI7619500

Tigecycline hydrate文献

Tigecycline inhibits proliferation of Acanthamoeba castellanii.

Parasitol. Res. 114(3) , 1189-95, (2015)

Acanthamoeba is an opportunistic protozoan parasite responsible for different diseases in humans, such as granulomatous amoebic encephalitis and amoebic keratitis. Tigecycline, a third-generation tetr...

Novel drug combination for Mycobacterium abscessus disease therapy identified in a Drosophila infection model.

J. Antimicrob. Chemother. 69(6) , 1599-607, (2014)

Mycobacterium abscessus is known to be the most drug-resistant Mycobacterium and accounts for ∼80% of pulmonary infections caused by rapidly growing mycobacteria. This study reports a new Drosophila m...

Pharmacokinetics of intravenously administered tigecycline in eye compartments: an experimental study.

Graefes Arch. Clin. Exp. Ophthalmol. 252(12) , 1993-7, (2014)

The purpose of this study was to evaluate the ocular distribution of intravenously administered tigecycline in a rabbit uveitis model.Tigecycline, which has a broad spectrum of activity against many g...

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