对氨基苯酚
对氨基苯酚用途
用途二：用于生产硫化蓝FBG、弱酸性嫩黄5G等染料，制造扑热息痛、安妥明等药物，也用于制显影剂、抗氧剂等
用途三：该品为医药、染料等精细化学品的中间体。用于生产药物扑热息痛、偶氮染料、硫化染料、酸性染料、毛皮染料以及显影剂、抗氧剂和石油添加剂等。
用途四：检定金，测定铜、铁、镁、钒、亚硝酸盐和氰酸盐，抗氧剂。
对氨基苯酚名称
[ CAS 号 ]:
123-30-8
[ 中文名 ]:
复硝酚钠
[ 英文名 ]:
4-Aminophenol
[中文别名 ]:
[英文别名 ]:
- 4-NH2-Phenol
- AZOL
- 4-amino-phenol
- Energol
- Unal
- Freedol
- Kathol
- 4-AMINOPHENOL 0,97
- |p|-Aminophenol
- 4-AMINO-1-HYDROXYBENZENE
对氨基苯酚物理化学性质
[ 密度 ]:
1.2±0.1 g/cm3
[ 沸点 ]:
282.0±23.0 °C at 760 mmHg
[ 熔点 ]:
188 °C
[ 分子式 ]:
C6H7NO
[ 分子量 ]:
109.126
[ 闪点 ]:
124.3±22.6 °C
[ 精确质量 ]:
109.052765
[ PSA ]:
46.25000
[ LogP ]:
-0.29
[ 外观性状 ]:
灰白色粒状的粉末
[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C
[ 折射率 ]:
1.637
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂分开存放
[ 稳定性 ]:
Stable, though may discolour in air. Incompatible with acids, chloroformates, strong oxidizing agents.
[ 水溶解性 ]:
1.5 g/100 mL (20 ºC)
对氨基苯酚MSDS
对氨基苯酚毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SJ5075000
- CHEMICAL NAME :
- Phenol, p-amino-
- CAS REGISTRY NUMBER :
- 123-30-8
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 53
- MOLECULAR FORMULA :
- C6-H7-N-O
- MOLECULAR WEIGHT :
- 109.14
- WISWESSER LINE NOTATION :
- ZR DQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 375 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 mg/kg/1H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 465 mg/kg
- TOXIC EFFECTS :
- Blood - methemoglobinemia-carboxyhemoglobin
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 675 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 470 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 37 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - cyanosis Blood - methemoglobinemia-carboxyhemoglobin Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 1530 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 6400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 563 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 56200 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1326 mg/kg/4W-I
- TOXIC EFFECTS :
- Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2500 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 667 mg/kg
- SEX/DURATION :
- female 11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 38850 mg/kg
- SEX/DURATION :
- female 13 week(s) pre-mating female 1-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 11100 mg/kg
- SEX/DURATION :
- female 13 week(s) pre-mating female 1-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 563 mg/kg
- SEX/DURATION :
- female 1-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 150 mg/kg
- SEX/DURATION :
- female 8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 200 mg/kg
- SEX/DURATION :
- female 8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - body wall
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 100 mg/kg
- SEX/DURATION :
- female 8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 150 mg/kg
- SEX/DURATION :
- female 8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - body wall
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Sperm Morphology
MUTATION DATA
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 26,163,1995 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1481 No. of Facilities: 5320 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 49882 (estimated) No. of Female Employees: 37110 (estimated)
对氨基苯酚安全信息
[ 符号 ]:
GHS07, GHS08, GHS09
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302 + H332-H341-H410
[ 警示性声明 ]:
P261-P280-P301 + P312 + P330
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ 危害码 (欧洲) ]:
Xn:Harmful
[ 风险声明 (欧洲) ]:
R20/22;R50/53;R68
[ 安全声明 (欧洲) ]:
S28-S36/37-S60-S61-S28A
[ 危险品运输编码 ]:
UN 2512 6.1/PG 3
[ WGK德国 ]:
3
[ RTECS号 ]:
SJ5075000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1
[ 海关编码 ]:
2922299090
对氨基苯酚合成路线
对氨基苯酚上下游产品
对氨基苯酚上游产品
对氨基苯酚下游产品
对氨基苯酚制备
1. 铁粉还原法 由对硝基酚还原而得。原料消耗定额：硝基苯酚（工业品）1388kg/t、铁粉1778kg/t、30%盐酸200kg/t。
2. 苯酚亚硝化法 由苯酚经亚硝化、还原、酸析而得。
3. 偶合还原法 以苯胺为原料，经重氮化、偶合、铁粉还原而得。
4. 硝基苯催化氢化法 多以铂，钯或二者作催化剂，在10-20%硫酸水溶液中氢化还原为苯基羟胺，随即转位对氨基酚，收率70-80%。在反应系统中加入表面活性剂等对提高产率有一定效果。5.硝基苯电解还原法 日本三井东压精细化学品公司采用在硫酸溶液中电解还原硝基苯，经苯基羟胺转位成对氨基酚，1977年6月该公司在大牟田工厂内建成一套1000吨/年装置。
对氨基苯酚海关
[ 海关编码 ]: 2922299090
[ 中文概述 ]:
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
对氨基苯酚文献
Drug Metab. Dispos. 38 , 2302-8, (2010)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...
Silver nanoparticles-decorated polyphosphazene nanotubes: synthesis and applications.Nanoscale 5(17) , 7913-9, (2013)
Herein, we report the preparation of poly (cyclotriphosphazene-co-4,4'-sulfonyldiphenol) (PZS) nanotubes decorated with Ag nanoparticles (NPs). The PZS nanotubes have been synthesized firstly via an i...
Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater.J. Pharm. Biomed. Anal. 106 , 61-70, (2015)
An analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic gro...
相关化工产品/化学物质：
推荐生产厂家/供应商：
公司名：上海化源世纪贸易有限公司
区域：上海市普陀区
价格：
联系人：徐经理
产品详情：对氨基酚
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥168.0/500g
联系人：刘佳
产品详情：对氨基酚
公司名：上海源溪生物科技有限公司
区域：上海市浦东新区
价格：
￥需询单/1g
联系人：赖经理
产品详情：NSC 1545
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥169.0/1g
￥需询单/1g
￥需询单/1g
￥需询单/1g
联系人：阿拉丁
产品详情：对氨基酚
公司名：中山市迪欣化工有限公司
区域：中山市三角镇
价格：
￥102.0/1000kg
联系人：王洁
产品详情：对氨基苯酚（对羟基苯胺）
查看所有供应商请点击：
相关化合物
【对氨基苯酚】化源网提供对氨基苯酚CAS号123-30-8，对氨基苯酚MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询对氨基苯酚上化源网，专业又轻松。>>电脑版：对氨基苯酚
标题：对氨基苯酚_MSDS_用途_密度_对氨基苯酚CAS号【123-30-8】_化源网 地址：https://m.chemsrc.com/mip/cas/123-30-8_1153427.html