二丙酮醇
二丙酮醇用途
用作高沸点溶剂、喷漆稀释剂、木材着色剂、除锈剂及染料等的原料
【用途二】
用作染料的原料及树脂的溶液
【用途三】
二丙酮醇是由丙酮制造亚异丙基丙酮、甲基异丁基酮、甲基异丁基甲醇及己二醇、佛尔酮、异佛尔酮过程中的中间体二丙酮醇可用以制取金属清洁剂、木材防腐剂、照相软片和药物的防腐剂、抗冻剂、液压油溶剂、萃取剂和纤维整理剂等。二丙酮醇广泛用作静电喷漆、赛璐珞、硝化纤维、脂肪、油脂、蜡和树脂等的溶剂。
【用途四】
乙酸纤维素和酯化纤维素、赛璐珞等的溶剂。生化研究。电泳分析。木材防腐剂。
二丙酮醇名称
[ CAS 号 ]:
123-42-2
[ 中文名 ]:
4-羟基-4-甲基-2-戊酮
[ 英文名 ]:
4-Hydroxy-4-methyl-2-pentanone
[中文别名 ]:
[英文别名 ]:
- MFCD00004471
- EINECS 204-626-7
- 4-hydroxy-4-methylpentan-2-one
- 4-Hydroxy-4-methyl-2-pentanone
- Diacetone Alcohol
二丙酮醇物理化学性质
[ 密度 ]:
0.938
[ 沸点 ]:
166 ºC
[ 熔点 ]:
-42.8 °C
[ 分子式 ]:
C6H12O2
[ 分子量 ]:
116.158
[ 闪点 ]:
58 ºC
[ 精确质量 ]:
116.083733
[ PSA ]:
37.30000
[ LogP ]:
-0.09
[ 外观性状 ]:
透明无色液体
[ 蒸汽密度 ]:
4 (vs air)
[ 蒸汽压 ]:
0.5±0.6 mmHg at 25°C
[ 折射率 ]:
1.427
[ 储存条件 ]:
包装完整、轻装轻卸,库房通风、远离明火、高温、与氧化剂分开存放
[ 稳定性 ]:
Stable. Flammable. Incompatible with strong oxidizing agents, amines, ammonia, strong acids, strong bases, alkalies, aluminium.
[ 水溶解性 ]:
MISCIBLE
二丙酮醇MSDS
二丙酮醇毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SA9100000
- CHEMICAL NAME :
- 2-Pentanone, 4-hydroxy-4-methyl-
- CAS REGISTRY NUMBER :
- 123-42-2
- BEILSTEIN REFERENCE NO. :
- 1740440
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 44
- MOLECULAR FORMULA :
- C6-H12-O2
- MOLECULAR WEIGHT :
- 116.18
- WISWESSER LINE NOTATION :
- QX1&1&1V1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Human
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 28,262,1946
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 30,63,1948
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/29/1959
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 100 ppm
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - headache Gastrointestinal - nausea or vomiting
- REFERENCE :
- NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,21,1974
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 400 ppm
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,21,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 30,63,1948
- TYPE OF TEST :
- LC - Lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >1500 ppm/8H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/29/1959
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3024 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - coma
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 33,175,1928
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3950 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 45,669,1956
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 933 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583) Volume(issue)/page/year: -,3,1961
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 4653 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 33,175,1928
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 13500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,21,1974
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2792 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 33,175,1928
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2792 mg/kg
- TOXIC EFFECTS :
- Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 33,175,1928 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4494 mg/m3/6W-I
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536235 *** REVIEWS *** ACGIH TLV-TWA 238 mg/m3 (50 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 50 ppm (240 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,70,1971 OSHA PEL (Gen Indu):8H TWA 50 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 50 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 50 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 50 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-BELGIUM:TWA 50 ppm (238 mg/m3) JAN 1993 OEL-DENMARK:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-FINLAND:TWA 50 ppm (240 mg/m3);STEL 75 ppm (360 mg/m3) JAN 1993 OEL-FRANCE:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-GERMANY:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-RUSSIA:STEL 100 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-TURKEY:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 50 ppm (240 mg/m3);STEL 75 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIACETONE ALCOHOL-air:10H TWA 50 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4016 No. of Facilities: 20435 (estimated) No. of Industries: 191 No. of Occupations: 95 No. of Employees: 167915 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4016 No. of Facilities: 20857 (estimated) No. of Industries: 194 No. of Occupations: 116 No. of Employees: 264662 (estimated) No. of Female Employees: 67291 (estimated)
二丙酮醇安全信息
[ 符号 ]:
GHS02, GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H226-H319
[ 警示性声明 ]:
P305 + P351 + P338
[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
Xi:Irritant
[ 风险声明 (欧洲) ]:
R36
[ 安全声明 (欧洲) ]:
S24/25
[ 危险品运输编码 ]:
UN 1148 3/PG 3
[ WGK德国 ]:
1
[ RTECS号 ]:
SA9100000
[ 包装等级 ]:
III
[ 危险类别 ]:
3
[ 海关编码 ]:
2914130000
二丙酮醇合成路线
二丙酮醇上下游产品
二丙酮醇上游产品
二丙酮醇下游产品
二丙酮醇制备
1.由丙酮在碱性条件下经缩合而得。每吨产品消耗丙酮1250kg。将丙酮于10-20℃下在一段或多段催化剂床层中进行缩合反应。一段催化剂需保持较低的进口温度；多段催化剂床中间因设有内冷却器，进口温度可适当提高，应有足够的停留时间。催化剂为碱性物质，实验室中使用氢氧化钡，工业生产中采用氢氧化钙、氢氧化钠或阴离子交换树脂。反应转化率一般在50%以下，反应产物是丙酮、二丙酮醇和微量催化剂的混合物。产物先用弱有机酸中和至PH值4-5，然后减压精馏，在塔顶回收丙酮供循环使用，塔底为二丙酮醇，可直接作为成品。如再经减压精馏可获得较纯的产品。对于小批量生产时，可将三个或四个装有氢氧化钡的反应柱安装在50L的搪玻璃反应釜上，在反应柱顶部有回流冷凝器。将32L工业丙酮及沸石加入锅中，进行回流约100-120h即得粗品。粗品回收丙酮后，分馏回收84℃（1.333KPa）的馏分即为成品。也可采用连续反应装置，以丙酮为原料非均相催化合成DA的新方法，具体工艺如下：在反应器中装入一定量的催化剂强碱性阴离子交换树脂，从加料管将丙酮注入反应系统，充满反应器后溢流至蒸馏釜，釜液位以1/2为宜。控制不同的反应床温度和蒸馏温度，在反应系统平衡后，按一定速率连续出料和进料。末反应的丙酮不断地从蒸馏釜内蒸出，经冷凝后进入反应器与新进料的丙酮一起重新反应。这样，反应床能控制最佳反应温度之外，还始终保持较高的反应物浓度。产品经蒸馏釜富集后经出料管排出系统。工艺条件为：反应床温度50-55℃，进料速度0.50L/h，蒸馏釜沸腾温度65-75℃。釜液中含DA为25%-60%。
精制方法：用无水硫酸钙干燥后，于2.6664kPa压力下减压分馏。
二丙酮醇海关
[ 海关编码 ]: 2914400090
[ 中文概述 ]:
2914400090 其他酮醇及酮醛。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装
[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
二丙酮醇文献
J. Chem. Ecol. 32(7) , 1399-413, (2006)
The choice of a suitable oviposition site by female insects is essential for survival of their progeny. Both olfactory and contact cues of the oviposition site may mediate this choice. The polyphagous...
L-proline catalyzed asymmetric transfer aldol reaction between diacetone alcohol and aldehydes.Chem. Commun. (Camb.) (21) , 2450-1, (2004)
We demonstrate for the first time, L-proline as a chiral catalyst for transfer aldol reaction between aldehydes and diacetone alcohol.
Molecular probes of the mechanism of cytochrome P450. Oxygen traps a substrate radical intermediate.Arch. Biochem. Biophys. 507(1) , 111-8, (2011)
The diagnostic substrate tetramethylcyclopropane (TMCP) has been reexamined as a substrate with three drug- and xenobiotic-metabolizing cytochrome P450 enzymes, human CYP2E1, CYP3A4 and rat CYP2B1. Th...
相关化工产品/化学物质：
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产品详情：二丙酮醇
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥68.0/500ml
联系人：刘佳
产品详情：二丙酮醇
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
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￥需询单/1g
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区域：中山市三角镇
价格：
￥17.0/1000kg
联系人：陈雪萍
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公司名：济南世纪通达化工有限公司
区域：济南市天桥区
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￥12000.0/1ton
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相关化合物
【二丙酮醇】化源网提供二丙酮醇CAS号123-42-2，二丙酮醇MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询二丙酮醇上化源网，专业又轻松。>>电脑版：二丙酮醇
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