Tetrazine-Ph-NHCO-C3-NHS ester

Tetrazine-Ph-NHCO-C3-NHS ester用途

Tetrazine-Ph-NHCO-C3-NHS ester 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

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Tetrazine-Ph-NHCO-C3-NHS ester名称

[ CAS 号 ]:
1244040-64-9

[ 英文名 ]:
Tetrazine-Ph-NHCO-C3-NHS ester

Tetrazine-Ph-NHCO-C3-NHS ester生物活性

[ 描述 ]:

Tetrazine-Ph-NHCO-C3-NHS ester 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

PEGs

[体外研究]

PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。

[参考文献]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Tetrazine-Ph-NHCO-C3-NHS ester物理化学性质

[ 分子式 ]:
C₁₈H₁₈N₆O₅

[ 分子量 ]:
398.37300

[ 精确质量 ]:
398.13400

[ PSA ]:
144.34000

[ LogP ]:
0.65610

[ 储存条件 ]:
2-8°C，密封，干燥

Tetrazine-Ph-NHCO-C3-NHS ester安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危险品运输编码 ]:
NONH for all modes of transport

Tetrazine-Ph-NHCO-C3-NHS ester文献

Synthesis and evaluation of a series of 1,2,4,5-tetrazines for bioorthogonal conjugation.

Bioconjug. Chem. 22 , 2263-2270, (2011)

1,2,4,5-Tetrazines have been established as effective dienes for inverse electron demand [4 + 2] Diels-Alder cycloaddition reactions with strained alkenes for over 50 years. Recently, this reaction pa...

Tetrazine-based cycloadditions: application to pretargeted live cell imaging.

Bioconjug. Chem. 19 , 2297-2299, (2008)

Bioorthogonal tetrazine cycloadditions have been applied to live cell labeling. Tetrazines react irreversibly with the strained dienophile norbornene forming dihydropyrazine products and dinitrogen. T...

Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity.

J. Am. Chem. Soc. 130 , 13518-13519, (2008)

Described is a bioorthogonal reaction that proceeds with unusually fast reaction rates without need for catalysis: the cycloaddition of s-tetrazine and trans-cyclooctene derivatives. The reactions tol...

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