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己酰神经鞘氨醇

己酰神经鞘氨醇用途

C6神经酰胺是一种神经酰胺途径激活剂,对多种癌细胞系具有活性。C6神经酰胺可作为化疗药物的佐剂,增强抗肿瘤作用[1][2]。

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己酰神经鞘氨醇名称

[ CAS 号 ]:
124753-97-5

[ 中文名 ]:
己酰神经鞘氨醇

[ 英文名 ]:
N-(hexanoyl)sphing-4-enine

[中文别名 ]:

N-己酰基-D-神经鞘氨醇

[英文别名 ]:

N-Hexanoyl-D-sphingosine
N-hexanoyl-D-erythro-sphingosine
N-(hexanoyl)sphing-4-enine
N-(hexanoyl)-sphing-4-enine
MFCD00870174

己酰神经鞘氨醇生物活性

[ 描述 ]:

C6神经酰胺是一种神经酰胺途径激活剂,对多种癌细胞系具有活性。C6神经酰胺可作为化疗药物的佐剂,增强抗肿瘤作用[1][2]。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[参考文献]

[1]. Zhu Q, et, al. C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo. Cell Death Dis. 2011 Jan 27;2(1):e117.

[2]. Liu L, et, al. C6-ceramide treatment inhibits the proangiogenic activity of multiple myeloma exosomes via the miR-29b/Akt pathway. J Transl Med. 2020 Aug 3;18(1):298.

己酰神经鞘氨醇物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
574.7±50.0 °C at 760 mmHg

[ 熔点 ]:
76-77ºC

[ 分子式 ]:
C₂₄H₄₇NO₃

[ 分子量 ]:
397.63

[ 闪点 ]:
301.4±30.1 °C

[ 精确质量 ]:
397.355591

[ PSA ]:
69.56000

[ LogP ]:
8.02

[ 蒸汽压 ]:
0.0±3.6 mmHg at 25°C

[ 折射率 ]:
1.483

[ 储存条件 ]:
-20°C

己酰神经鞘氨醇MSDS

详细MSDS(安全技术说明书)

己酰神经鞘氨醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

己酰神经鞘氨醇文献

Stimulation of the cardiac myocyte Na+-K+ pump due to reversal of its constitutive oxidative inhibition.

Am. J. Physiol. Cell Physiol. 309 , C239-50, (2015)

Protein kinase C can activate NADPH oxidase and induce glutathionylation of the β1-Na(+)-K(+) pump subunit, inhibiting activity of the catalytic α-subunit. To examine if signaling of nitric oxide-indu...

Carbon nanoparticles induce ceramide- and lipid raft-dependent signalling in lung epithelial cells: a target for a preventive strategy against environmentally-induced lung inflammation.

Part. Fibre Toxicol. 9 , 48, (2012)

Particulate air pollution in lung epithelial cells induces pathogenic endpoints like proliferation, apoptosis, and pro-inflammatory reactions. The activation of the epidermal growth factor receptor (E...

Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo.

J. Exp. Clin. Cancer Res 34 , 94, (2015)

Colorectal cancer (CRC) is a major health problem in China and around the world. It is one of the leading causes of cancer-related deaths. Research groups are thus searching for novel and more efficie...

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